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Most cases are germ cell tumors (~95%) and sex cord-stromal tumors (~5%). TC is often detected before age 40 and has a favorable prognosis, with >95% 5-year survival improved by cisplatin-based chemotherapy since the late 1970s. Etiology is multifactorial, requiring accurate diagnosis using histological evaluation alongside biomarker research.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/new-insights-on-testicular-cancer-prevalence-with-novel-diagnostic-biomarkers-and-therapeutic-approaches-review/330265/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/new-insights-on-testicular-cancer-prevalence-with-novel-diagnostic-biomarkers-and-therapeutic-approaches-review/330265.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What proportion of testicular cancer cases are germ cell tumors and sex cord-stromal tumors?","Question",{"text":113,"@type":114},"Germ cell tumors account for about 95% of cases, while sex cord-stromal tumors account for about 5%. This classification is emphasized in the abstract.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is early detection before age 40 clinically important in testicular cancer?",{"text":118,"@type":114},"The abstract notes that TC is commonly detected before reaching 40, meaning patients can expect an additional 40–50 years of life after successful treatment. This highlights the value of timely diagnosis and effective therapy.",{"name":120,"@type":111,"acceptedAnswer":121},"What role do cisplatin-based chemotherapy and histological evaluation play?",{"text":122,"@type":114},"Cisplatin-based chemotherapy introduced in the late 1970s significantly improved 5-year survival to over 95%. For diagnosis, the abstract states that blood tests may help but an unequivocal diagnosis requires histological assessment by a pathologist.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},330265,1790099739,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","DOI: 10.1002/cnr2.2052  \nREVIE W  \nNew insights on testicular cancer prevalence with novel diagnostic biomarkers and therapeutic approaches  \nKadry M. Sadek 1 | Hazem Y. AbdEllatief 1 | Sahar F. E. Mahmoud 2 | Athanasios Alexiou 3,4,5,6  | Marios Papadakis 7 | Marwan Al-Hajeili 8 | Hebatallah M. Saad 9  | Gaber El-Saber Batiha 10   \n1Department of Biochemistry, Faculty of Veterinary Medicine, Damanhour University, Abadiyyat Damanhur, Egypt 2Department of Histology, Faculty of Veterinary Medicine, Damanhour University, Abadiyyat Damanhur, Egypt 3University Centre for Research and Development, Chandigarh University, Mohali, Punjab, India  \n4Department of Research and Development, Funogen, Athens, Greece 5Department of Research and Development, AFNP Med, Wien, Austria  \n6Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, New South Wales, Australia  \n7Department of Surgery II, University Hospital Witten-Herdecke, Wuppertal, Germany 8Department of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia 9Department of Pathology, Faculty of Veterinary Medicine, Matrouh University, Marsa Matruh, Egypt  \n10Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt  \nCorrespondence  \nMarios Papadakis, Department of Surgery II, University Hospital Witten-Herdecke, Heusnerstrasse 40, University of WittenHerdecke, 42283, Wuppertal, Germany.  \nEmail: [drmariospapadakis@gmail.com](drmariospapadakis@gmail.com)  \nHebatallah M. Saad, Department of Pathology, Faculty of Veterinary Medicine, Matrouh University, Marsa Matruh 51744, Egypt.  \nEmail: [heba.magdy@mau.edu.eg](heba.magdy@mau.edu.eg)  \nGaber El-Saber Batiha, Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.  \nEmail: [dr_gaber_batiha@vetmed.dmu.edu.eg](dr_gaber_batiha@vetmed.dmu.edu.eg)  \nFunding information  \nUniversity of Witten-Herdecke Germany  \nAbstract  \nBackground: Testicular cancer (TC), comprising merely 1% of male neoplasms, holds the distinction of being the most commonly encountered neoplasm among young males.  \nRecent findings: Most cases of testicular neoplasms can be classified into two main groups, namely germ cell tumors representing approximately 95% of the cases, and sex cord-stromal tumors accounting for about 5% of the cases. Moreover, its prevalence is on the rise across the globe. TC is a neoplastic condition characterized by a favorable prognosis. The advent of cisplatin-based chemotherapeutic agents in the latter part of the 1970s has led to a significant enhancement in the 5-year survival rate, which presently surpasses 95% . Given that TC is commonly detected before reaching the age of 40, it can be anticipated that these individuals will enjoy an additional 40–50 years of life following successful treatment. The potential causes of TCare multifactorial and related to different pathologies. Accurate identification is imperative to guarantee the utmost efficacious and suitable therapy. To a certain degree, this can be accomplished through the utilization of blood examinations for neoplastic indicators; nonetheless, an unequivocal diagnosis necessitates an evaluation of the histological composition of a specimen via a pathologist.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Authors. Cancer Reports published by Wiley Periodicals LLC.  \nCancer Reports. 2024;7:e2052 .  \n[https://doi.org/10.1002/cnr2.2052](https://doi.org/10.1002/cnr2.2052)  \n[wileyonlinelibrary.com/journal/cnr2](wileyonlinelibrary.com/journal/cnr2)  \n1 of 13  \nConclusion: TC is multifactorial and has various pathologies, therefore this review aimed to revise the prenatal and postnatal causes as well as novel diagnostic biomarkers and the therape","cbCaic40U7FJoeEX","https://ap.wps.com/l/cbCaic40U7FJoeEX","pdf",1700391,13,"English","# Abstract\n## Background and classification\n## Recent findings and prognosis\n## Etiology, diagnosis, and review aim\n# Conclusion\n# Key topics in introduction","[{\"question\":\"What proportion of testicular cancer cases are germ cell tumors and sex cord-stromal tumors?\",\"answer\":\"Germ cell tumors account for about 95% of cases, while sex cord-stromal tumors account for about 5%. This classification is emphasized in the abstract.\"},{\"question\":\"Why is early detection before age 40 clinically important in testicular cancer?\",\"answer\":\"The abstract notes that TC is commonly detected before reaching 40, meaning patients can expect an additional 40–50 years of life after successful treatment. This highlights the value of timely diagnosis and effective therapy.\"},{\"question\":\"What role do cisplatin-based chemotherapy and histological evaluation play?\",\"answer\":\"Cisplatin-based chemotherapy introduced in the late 1970s significantly improved 5-year survival to over 95%. For diagnosis, the abstract states that blood tests may help but an unequivocal diagnosis requires histological assessment by a pathologist.\"}]","New insights on testicular cancer prevalence with novel diagnostic biomarkers and therapeutic approaches - Review | PDF",1789987943,33]