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Evidence indicates that NT expression is regulated by sex steroid hormones, particularly estradiol. In this narrative review, the authors examine NT, NTR1, and SORT1 in three female hormone-sensitive cancers: breast, ovarian, and endometrial cancer. Their roles in proliferation, invasion, and prognosis align across cases, supporting NT receptor-targeted theranostics and radioligand treatments as personalized therapeutic options.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/neurotensin-and-its-involvement-in-female-hormone-sensitive-cancers-narrative-review/332713/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/neurotensin-and-its-involvement-in-female-hormone-sensitive-cancers-narrative-review/332713.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is neurotensin (NT) and what biological processes does it influence?","Question",{"text":112,"@type":113},"NT is a 13-amino-acid peptide involved in digestion, neuromodulation, and cancer progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which receptors and related factors are emphasized in this review?",{"text":117,"@type":113},"The review focuses on NT and its receptors, mainly NTR1 and SORT1 (NTR1 and SORT1 are highlighted as key receptors, with NTR2 also discussed in the receptor context).",{"name":119,"@type":110,"acceptedAnswer":120},"How does NT relate to female hormone-sensitive cancers and personalized treatment?",{"text":121,"@type":113},"NT expression is controlled by sex steroid hormones, especially estradiol, and NT/NTR1/SORT1 are largely expressed in breast, ovarian, and endometrial cancers, aligning with tumor processes such as proliferation and invasion. 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Neurotensin and Its Involvement in Female HormoneSensitive Cancers. Int. J. Mol. Sci. 2024, 25, 11648. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms252111648](10.3390/ijms252111648)  \nAcademic Editor: Silvia Cantara  \nReceived: 24 September 2024  \nRevised: 28 October 2024  \nAccepted: 28 October 2024  \nPublished: 30 October 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Gynecology and Obstetrics, CHRU de Nancy, Université de Lorraine, F-54000 Nancy, France; [n.bertrand@chru-nancy.fr](n.bertrand@chru-nancy.fr)  \n2 Department of Fertility Medicine, CHRU de Nancy, Université de Lorraine, F-54000 Nancy, France; [r.mougel@chru-nancy.fr](r.mougel@chru-nancy.fr)  \n3 Department of Endocrinology, Diabetes and Nutrition, CHRU de Nancy, Université de Lorraine, F-54500 Vandœuvre-lès-Nancy, France; [g.riley@chru-nancy.fr](g.riley@chru-nancy.fr)  \n4 Department of Radiation Therapy, Institut de Cancérologie de Lorraine, F-54500 Vandoeuvre-lès-Nancy, France; [m.bruand@nancy.unicancer.fr](m.bruand@nancy.unicancer.fr)  \n5 Department of Pathology, CHRU de Nancy, Université de Lorraine, F-54500 Vandœuvre-lès-Nancy, France; [g.gauchotte@chru-nancy.fr](g.gauchotte@chru-nancy.fr)  \n6 INSERM UMRS 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Université de Lorraine, F-54500 Vandœuvre-lès-Nancy, France  \n* [Correspondence: m.agopiantz@chru-nancy.fr](Correspondence: m.agopiantz@chru-nancy.fr); Tel.: +33-3-83-34-44-26  \nAbstract: Neurotensin (NT) is a peptide involved in digestion, neuromodulation, and cancer progression. NT and its receptors (NTR1 and SORT1 mainly) have been widely studied in oncology. Data show that NT expression is under the control of sex steroid hormones, in particular estradiol. We focused on its involvement in three main female hormone-sensitive cancers, breast, ovarian, and endometrial cancer, in a narrative review. NT, NTR1, and SORT1 are mostly expressed in these three cancers, and their involvement in oncologic processes such as proliferation and invasion seems to match, as does their impact on prognosis for most. The development of NT receptor-targeted therapies, including theranostics and radioligand treatments, presents a promising avenue for personalized cancer treatment.  \nKeywords: neurotensin; breast cancer; ovarian cancer; endometrial cancer  \n1. Introduction  \nNeurotensin (NT) is a 13-amino-acid peptide originally isolated from the bovine hypothalamus by Carraway and Leeman in 1973 [1] . NT is found both within the central nervous system and in the gastrointestinal tract. On one hand, in the brain, NT has shown different roles, such as neuromodulation of dopamine transmission [2] or hypothermia and analgesia [3] . Thus, it has been studied in different pathologies such as schizophrenia [4] and Parkinson’s disease [5] . On the other hand, in the digestive system, it exerts a variety of effects including the inhibition of gastric and small-bowel motility or the facilitation of fatty acid translocation [6] . NT’s role as a growth factor in many tissues has been widely studied, as has its involvement in cancer [7] .  \nThese different effects are mediated through three receptors. The first NT receptor (NTR1) was cloned in 1990 by Nakanishi et al., who showed that it belonged to the family of G-protein-coupled receptors [8] . Similarly, NTR2 also belongs to the G-pro","cbCainO99Wa35PJR","https://ap.wps.com/l/cbCainO99Wa35PJR","pdf",538177,12,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"What is neurotensin (NT) and what biological processes does it influence?\",\"answer\":\"NT is a 13-amino-acid peptide involved in digestion, neuromodulation, and cancer progression.\"},{\"question\":\"Which receptors and related factors are emphasized in this review?\",\"answer\":\"The review focuses on NT and its receptors, mainly NTR1 and SORT1 (NTR1 and SORT1 are highlighted as key receptors, with NTR2 also discussed in the receptor context).\"},{\"question\":\"How does NT relate to female hormone-sensitive cancers and personalized treatment?\",\"answer\":\"NT expression is controlled by sex steroid hormones, especially estradiol, and NT/NTR1/SORT1 are largely expressed in breast, ovarian, and endometrial cancers, aligning with tumor processes such as proliferation and invasion. Targeted therapies, including theranostics and radioligand treatments, are presented as promising for personalized cancer care.\"}]","Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers - Narrative review | PDF",1789999181]