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This study evaluates Taraxacum officinale L. leaf extract (TOE), rich in polyphenols such as luteolin and quercetin, for neuroprotection against cisplatin-induced peripheral neuropathy. Molecular docking targeted NF-κB1, and in vivo experiments in mice assessed behavior and biochemical oxidative/inflammatory markers. TOE significantly improved functional outcomes and reduced oxidative and proinflammatory signals, supporting further clinical exploration.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/neuroprotective-potential-of-taraxacum-officinale-leaf-extract-against-cisplatin-neuropathy-via-antioxidative-modulation/438585/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/neuroprotective-potential-of-taraxacum-officinale-leaf-extract-against-cisplatin-neuropathy-via-antioxidative-modulation/438585.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why does cisplatin cause peripheral neuropathy?","Question",{"text":112,"@type":113},"Cisplatin-induced peripheral neuropathy is driven by oxidative stress and neuroinflammatory pathways, including NF-κB, TNF-α, and IL-6, leading to sensory and motor impairments.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is Taraxacum officinale leaf extract (TOE) and what compounds are emphasized?",{"text":117,"@type":113},"TOE is derived from Taraxacum officinale leaves and is rich in polyphenols such as luteolin and quercetin, which are linked to antioxidant and anti-inflammatory effects.",{"name":119,"@type":110,"acceptedAnswer":120},"How was TOE tested in the study?",{"text":121,"@type":113},"Male Wistar albino mice received weekly cisplatin injections to induce CIPN, while TOE was administered intragastrically daily. The study then evaluated behavior (rotarod, hot plate, cold plate, tail-flick) and measured antioxidant enzymes, oxidative stress markers, and inflammatory cytokines.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},438585,1790792778,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Article published online: 2025-12-08  \nOriginal Article 1  \nNeuroprotetive potential of Taraxacum officinale leaf extract against cisplatin neuropathy via antioxidative modulation  \nMehmet Erdem 1,2 Hasan Ulusal3 Mehmet Özaslan2  \n1 Gaziantep University, Department of Health Services Vocational School, Gaziantep, Türkiye.  \n2 Gaziantep University, Department of Biology, Gaziantep, Türkiye.  \n3 Gaziantep Islam Science and Technology University, Department of Medical Biochemistry, Gaziantep, Türkiye.  \nArq. Neuro-Psiquiatr. 2025;83(11):s00451813237 .  \nAddress for correspondence Mehmet Özaslan (email: [ozaslanmd@gantep.edu.tr](ozaslanmd@gantep.edu.tr))  \nAbstract  \nKeywords  \n► Cisplatin  \n► Peripheral Nervous System Diseases  \n► Taraxacum  \n► Oxidative Stress  \n► Antioxidants  \n► Enzymes  \n► Neuroprotection  \nBackground Cisplatin, a potent platinum-based chemotherapeutic, effectively treats various cancers. However, it is limited by cisplatin-induced peripheral neuropathy (CIPN), driven by oxidative stress and neuroinflammation.  \nObjective The present study investigates the neuroprotective potential of Taraxacum officinale L. leaf extract (TOE), rich in polyphenols such as luteolin and quercetin, known for their antioxidant and antiinflammatory properties.  \nMethods Molecular docking of 10 polyphenols against NF-κB1 revealed that luteolin and quercetin outperform synthetic inhibitors, forming strong interactions with key residues. These compounds exhibited favorable pharmacokinetics, including high gastrointestinal absorption and nontoxicity. The CIPN was induced in male Wistar albino mice (3 mg/kg cisplatin, i.p. , weekly for 5 weeks), with TOE (500 mg/kg, intragastric, daily) or saline administered concurrently. A TOE-only group served as a control. Behavioral assessments (rotarod, hot plate, cold plate, tail flick) evaluated sensory and motor function, while biochemical assays measured antioxidant enzymes (CAT, GPx1, SOD2), oxidative stress markers (MDA, TOS, IMA), and proinflammatory cytokines (NF-κB, TNF-α, IL-6) in serum and sciatic nerve tissues.  \nResults Cisplatin induced significant behavioral deficits, reduced antioxidant capacity, and elevated oxidative and inflammatory markers. The TOE significantly ameliorated these effects, restoring behavior, enhancing antioxidant status, and reducing inflammation, consistent with the in silico predictions of NF-κB1 inhibition. Conclusion These findings highlight T. officinale as a promising, safe, complementary therapy for CIPN, warranting further clinical exploration.  \nINTRODUCTION  \nCisplatin (CIS), a cornerstone platinum-based chemotherapeutic, is widely used to treat malignancies such as ovarian,  \nreceived  \nAugust 1, 2025  \nreceived in its final form August 28, 2025  \naccepted  \nSeptember 4, 2025  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)10.1055/s-0045-1813237 . ISSN 0004-282X.  \nEditor-in-Chief: Hélio A. G. Teive.  \nAssociate Editor: Karina Braga Gomes.  \ntesticular, and lung cancers.1 However, its clinical utility is constrained by dose-dependent neurotoxic side effects, particularly CIS-induced peripheral neuropathy (CIPN), which affects 60 to 70% of patients.2 This condition manifests as  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/))  \nThieme Revinter Publicações Ltda. , Rua Rego Freitas, 175, loja 1, República, São Paulo, SP, CEP 01220-010, Brazil  \n2 Effects of T. officinale extract on neurotoxicity Erdem et al.  \nsensory and motor impairments, including paresthesia, dysesthesia, and neuropathic pain, driven by oxidative stress from excessive reactive oxygen species (ROS) and neuroinflammatory pathways involving nuclear factor-kappa B (NF-κB), tumor necrosis facto","cbCaiguPGmeF6Els","https://ap.wps.com/l/cbCaiguPGmeF6Els","pdf",6302833,"English","# Abstract\n## Background\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n# Methods\n## Plant collection, extraction, and polyphenol profiling","[{\"question\":\"Why does cisplatin cause peripheral neuropathy?\",\"answer\":\"Cisplatin-induced peripheral neuropathy is driven by oxidative stress and neuroinflammatory pathways, including NF-κB, TNF-α, and IL-6, leading to sensory and motor impairments.\"},{\"question\":\"What is Taraxacum officinale leaf extract (TOE) and what compounds are emphasized?\",\"answer\":\"TOE is derived from Taraxacum officinale leaves and is rich in polyphenols such as luteolin and quercetin, which are linked to antioxidant and anti-inflammatory effects.\"},{\"question\":\"How was TOE tested in the study?\",\"answer\":\"Male Wistar albino mice received weekly cisplatin injections to induce CIPN, while TOE was administered intragastrically daily. The study then evaluated behavior (rotarod, hot plate, cold plate, tail-flick) and measured antioxidant enzymes, oxidative stress markers, and inflammatory cytokines.\"}]","Neuroprotective potential of Taraxacum officinale leaf extract against cisplatin neuropathy via antioxidative modulation | PDF",1790685795,25]