[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-356961-105":59,"doc-detail-356961-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","neuroinflammation-and-ramp1-the-role-of-the-peripheral-and-central-nervous-system-in-tumor-progression","Neuroinflammation and RAMP1: the Role of the Peripheral and Central Nervous System in Tumor Progression","","Calcitonin gene-related peptide (CGRP) and receptor activity modifier protein 1 (RAMP1) define a key neuroimmunoendocrine pathway governing neuroinflammation, pain, and tumor progression. CGRP modulates vasodilation and nociception via receptors built from CALCRL and RAMP1. In the CNS, microglial and astrocytic activation triggers NF-κB and MAPK signaling, generating proinflammatory cytokines. Preclinical models show that genetic or pharmacologic disruption of CGRP/RAMP1 reduces angiogenesis, pro-tumor immune infiltration, tumor growth, and nociceptive behavior, supporting translational strategies and biomarker and safety evaluation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/neuroinflammation-and-ramp1-the-role-of-the-peripheral-and-central-nervous-system-in-tumor-progression/356961/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/neuroinflammation-and-ramp1-the-role-of-the-peripheral-and-central-nervous-system-in-tumor-progression/356961.png","ImageObject",300,407,{"name":92,"@type":93},"supergirl","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological roles do CGRP and RAMP1 play in tumor progression?","Question",{"text":112,"@type":113},"CGRP and RAMP1 form a neuroimmunoendocrine axis that modulates neuroinflammation, pain, and tumor progression by promoting vascular permeability, cytokine release, and angiogenesis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the CNS environment influence inflammation compared with systemic inflammation?",{"text":117,"@type":113},"Central nervous system inflammation differs from systemic inflammation due to the blood-brain barrier and the glial microenvironment, leading to specific microglial/astrocytic signaling.",{"name":119,"@type":110,"acceptedAnswer":120},"What therapeutic strategy is proposed based on available CGRP-targeting drugs?",{"text":121,"@type":113},"Blocking the CGRP/RAMP1 axis is presented as a promising translational approach, leveraging the clinical availability of CGRP antagonists and monoclonal antibodies to modulate tumor progression and cancer pain.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},356961,1790217045,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":56,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962088121634,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Cell Biochemistry and Biophysics (2026) 84:1725–1743  \n[https://doi.org/10.1007/s12013-026-02009-z](https://doi.org/10.1007/s12013-026-02009-z)  \nREVIEW PAPER  \nNeuroinflammation and RAMP1: the Role of the Peripheral and Central Nervous System in Tumor Progression  \nPedro Daniel Moumesso Cavalcante1 · Jonas Lucas Dias da Silva 1 · Laryssa Rosy Santos Oliveira1 ·  \nRikelly Barbosa da Silva 1 · Juliana Acioli Costa Lima 1 · Guilherme de Brito Souza 1 · Davi Ramon da Silva Santos 1 · JúlliaVictória Nascimento de Abrantes1 · Mateus Lima de Farias 1 · Sofia Amancio de Almeida Oliveira1 ·  \nJoão Paulo Emiliano da Silva1,2 · Rafael de Oliveira Calaça Farias1,2 · Leonardo Prudêncio Coutinho de Almeida1,2 · Salomão Belfort Sparapan de Melo1,2 · Sandra Taveiros de Araújo 1 · Raimundo Rodrigues de França-Júnior 1 · José Emerson Xavier 1 · Carlos Alberto de Carvalho Fraga1,2  \nAccepted: 17 January 2026 / Published online: 6 February 2026 © The Author(s) 2026  \nAbstract  \nCalcitonin gene-related peptide (CGRP) and receptor activity modifier protein 1 (RAMP1) form a critical neuroimmunoendocrine axis in the modulation of neuroinflammation, pain, and tumor progression. CGRP, released by sensory and sympathetic fibers, is a potent vasodilator and nociceptive modulator; its action depends on the receptor composed of CALCRL and RAMP1 . In the central nervous system, the activation of microglia and astrocytes and the induction of pathways such as NF-κB and MAPK culminate in the production of proinflammatory cytokines (TNF-α, IL-6), differing from systemic inflammation due to the presence of the blood-brain barrier and the glial microenvironment. Preclinical evidence demonstrates RAMP1 expression in neurons, glial cells, endothelium, and macrophages; CGRP/RAMP1 signaling promotes vascular permeability, cytokine release, and angiogenesis, potentially synergizing with VEGF. In animal models and cell cultures, genetic or pharmacological manipulations of the axis reduce tumor angiogenesis, pro-tumor immune infiltration, tumor growth, and nociceptive behavior. Given the clinical availability of CGRP antagonists and monoclonal antibodies, blocking the CGRP/RAMP1 axis is a promising translational strategy for modulating tumor progression and cancer pain. This review summarizes preclinical evidence on mechanisms and therapeutic feasibility. The article includes preclinical and clinical safety and biomarker studies.  \nKeywords Calcitonin Gene-Related peptide · RAMP, neuroinflammation · Tumor microenvironment · Cell proliferation  \nAbbreviations  \nAbbreviations  \nAC  \nADM  \nAKT  \nBBB  \nMeaning Adenylate cyclase Adrenomedulin Protein kinase B Blood-brain barrier  \n􀀍 Carlos Alberto de Carvalho Fraga [carlos.fraga@arapiraca.ufal.br](carlos.fraga@arapiraca.ufal.br)  \n1 Federal University of Alagoas, Arapiraca Campus, Center for Medical Sciences, Av. Manoel Severino Barbosa, Bom SucessoCEP 57309-005 Arapiraca, AL, Arapiraca, Brazil  \n2 CMOL – Computational and Molecular Laboratory, Av. Manoel Severino Barbosa, Bom Sucesso, CEP 57309-005 Arapiraca, AL, Arapiraca, Brazil  \ncAMP  \nCCL2  \nCGRP  \nCGRP-R  \nCLR  \nCNS  \nCXCL10  \nDAMP  \nDRG  \nECD  \nFTS  \nGAL-3  \nGBM  \nGRK  \nHPA  \nIAPP  \nCyclic AMP  \nChemokine ligand 2 with CC motif Calcitonin gene-related peptide CGRP receptor  \nCalcitonin-Like Receptor Central nervous system  \nChemokine ligand 10 with CXC motif Damage-associated molecular pattern  \nDorsal root ganglia Extracellular domain Farnesyl thiosalicylic acid Galectin-3  \nGlioblastoma  \nG protein-coupled receptor Hypothalamus-pituitary-adrenal axis Amylin  \nIL Interleukin  \nJAK-STAT Janus Kinase/Signal Transducer and Transcription Activato  \nMAPK Mitogen-activated protein kinase  \nmRNA Messenger RNA  \nNE Noradrenaline  \nNF-κB Nuclear Factor Kappa B  \nNLRP3 Nucleotide-Binding Domain, Leucine  \nRich Family, Pyrin-Containing Domain 3 PAMP Pathogen-associated molecular pattern  \nPKA Protein KinaseA  \nPNS Peripheral nervous system  \nPRR Pattern Recognition Receiver  ","cbCaiag5Mft2Zsr5","https://ap.wps.com/l/cbCaiag5Mft2Zsr5","pdf",1584193,"English","# Abstract\n# Keywords\n# Abbreviations\n# Basic Concepts about CGRP and RAMP1\n# CGRP/RAMP1 Axis Signaling","[{\"question\":\"What biological roles do CGRP and RAMP1 play in tumor progression?\",\"answer\":\"CGRP and RAMP1 form a neuroimmunoendocrine axis that modulates neuroinflammation, pain, and tumor progression by promoting vascular permeability, cytokine release, and angiogenesis.\"},{\"question\":\"How does the CNS environment influence inflammation compared with systemic inflammation?\",\"answer\":\"Central nervous system inflammation differs from systemic inflammation due to the blood-brain barrier and the glial microenvironment, leading to specific microglial/astrocytic signaling.\"},{\"question\":\"What therapeutic strategy is proposed based on available CGRP-targeting drugs?\",\"answer\":\"Blocking the CGRP/RAMP1 axis is presented as a promising translational approach, leveraging the clinical availability of CGRP antagonists and monoclonal antibodies to modulate tumor progression and cancer pain.\"}]","Neuroinflammation and RAMP1: the Role of the Peripheral and Central Nervous System in Tumor Progression | PDF",1790128450,48]