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Immune-related adverse events can trigger organ-specific inflammatory complications, including kidney injury. This systematic review examines kidney problems arising from chemotherapy and immunotherapy, detailing mechanisms, risk factors, management, and safety, including proteinuria, hypertension, electrolyte abnormalities, glomerulonephritis, and acute renal injury leading to AKI.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nephrological-detrimental-impacts-resulting-from-novel-immunotherapy-drugs-used-in-the-treatment-of-cancer-a-systematic-review/330273/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nephrological-detrimental-impacts-resulting-from-novel-immunotherapy-drugs-used-in-the-treatment-of-cancer-a-systematic-review/330273.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What kidney complications are linked to antineoplastic and immunotherapy treatments?","Question",{"text":112,"@type":113},"Antineoplastic medications can affect any part of the kidney, leading to proteinuria, hypertension, electrolyte abnormalities, glomerulonephritis, and both acute and chronic interstitial nephritis, including acute kidney injury (AKI).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which risk factors for AKI are evaluated in the review?",{"text":117,"@type":113},"The review examines risk factors such as age, gender, preexisting conditions (including diabetes, hypertension, and chronic kidney disease), and baseline medications including NSAIDs, renin-angiotensin system inhibitors, allopurinol, diuretics, corticosteroids, and proton pump inhibitors.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the review recommend managing immunotherapy-related kidney side effects?",{"text":121,"@type":113},"It emphasizes prompt recognition and effective management of side effects, including tailored corticosteroid use and alignment with CTCAE recommendations. It also highlights examples such as management of AKI and proteinuria associated with novel immunotherapy drugs like pembrolizumab.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330273,1790195455,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Open Access Review  \nArticle DOI: 10.7759/cureus.54487  \nReceived 01/25/2024  \nReview began 02/04/2024  \nReview ended 02/11/2024  \nPublished 02/19/2024  \n© Copyright 2024  \nJaiswal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nNephrological Detrimental Impacts Resulting From Novel Immunotherapy Drugs Used in the Treatment of Cancer: A Systematic Review  \nAmisha Jaiswal 1, Kainaat Shergill 2, Kusalik Boppana 1, Naiela E. Almansouri 1, 3, Saloni Bakkannavar 4, Youmna Faheem 5, Tuheen Sankar Nath 6  \n1. Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA 2. Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA 3. Internal Medicine, University of Tripoli, Tripoli, LBY 4. Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA 5. Pediatrics, Ras Al Khaimah (RAK) Medical & Health Sciences University, Ras Al Khaimah, ARE 6. Surgical Oncology, Tata Medical Centre, Kolkata, IND  \nCorresponding author: Amisha Jaiswal, [amishajais1@gmail.com](amishajais1@gmail.com)  \nAbstract  \nThe most recent advancements in cancer therapy center on efficiently and conveniently enhancing a patient 's natural immune system. Immune checkpoint inhibitors (ICIs) are antibodies that target cytotoxic thymus (T) lymphocyte antigen-4 (CTLA-4) and its receptor. They function by stimulating T-cell activity against malignancies. Immune-related adverse events (irAEs) are a distinct class of inflammatory side effects that are specific to a given organ. Antineoplastic medications can impact any part of the kidney, leading to the development of proteinuria, hypertension, electrolyte abnormalities, glomerulonephritis, and both acute and chronic interstitial nephritis. We reviewed the scientific literature regarding kidney problems that can arise from chemotherapy and immunotherapy for neoplasms, such as various cancers, melanoma, nonsmall cell lung cancer, and colorectal cancer. We discussed the pathophysiology, associated risk factors, management, and safety measures for patients experiencing acute renal injury after a new immunotherapy medication treatment. Antineoplastic drugs have the potential to damage the renal tubules, glomeruli, parenchyma, and blood vessels, among other kidney tissues. This can result in a broad spectrum of complications, spanning from a rise in serum creatinine levels without symptoms to the development of acute kidney injury (AKI) . The research examined a range of risk factors associated with acute kidney injury (AKI) . These factors encompassed age, gender, preexisting medical conditions (such as diabetes, hypertension, and chronic kidney disease), and the medications that patients were taking at the beginning of the study, which included non-steroidal anti-inflammatory drugs, renin-angiotensin system inhibitors, allopurinol, diuretics, corticosteroids, and proton pump inhibitors. The data suggests that patients who were receiving baseline treatment with proton pump inhibitors (PPIs) or corticosteroids had a higher risk of mortality. This study serves as an illustration of the effective management of acute kidney injury and proteinuria linked to novel immunotherapy drugs like pembrolizumab. The approach involved the use of corticosteroids tailored to the patient 's condition. Furthermore, it references the recommendations outlined in the Common Terminology Criteria for Adverse Events (CTCAE) . Prompt recognition and effective management of these side effects are essential to optimizing outcomes for patients undergoing immunotherapy. Our results were refined and focused by utilizing Medical Subject Headings (MeSH) keywords in our search strategy. The MeSH keywords used were \"renal side effects \" OR \"immunotherapy \" OR\"c","cbCaikxgz7rEcoYU","https://ap.wps.com/l/cbCaikxgz7rEcoYU","pdf",494240,12,"English","# Abstract\n# Introduction and Background\n# How to Cite This Article","[{\"question\":\"What kidney complications are linked to antineoplastic and immunotherapy treatments?\",\"answer\":\"Antineoplastic medications can affect any part of the kidney, leading to proteinuria, hypertension, electrolyte abnormalities, glomerulonephritis, and both acute and chronic interstitial nephritis, including acute kidney injury (AKI).\"},{\"question\":\"Which risk factors for AKI are evaluated in the review?\",\"answer\":\"The review examines risk factors such as age, gender, preexisting conditions (including diabetes, hypertension, and chronic kidney disease), and baseline medications including NSAIDs, renin-angiotensin system inhibitors, allopurinol, diuretics, corticosteroids, and proton pump inhibitors.\"},{\"question\":\"How does the review recommend managing immunotherapy-related kidney side effects?\",\"answer\":\"It emphasizes prompt recognition and effective management of side effects, including tailored corticosteroid use and alignment with CTCAE recommendations. It also highlights examples such as management of AKI and proteinuria associated with novel immunotherapy drugs like pembrolizumab.\"}]","Nephrological Detrimental Impacts Resulting From Novel Immunotherapy Drugs Used in the Treatment of Cancer - A Systematic Review | PDF",1789987964]