[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-46508-en":3,"doc-seo-46508-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":13,"seo_description":14,"update_tm":28,"read_time":29},46508,1099513958762,"Logic","https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1782109480056885918",7,"Healthcare","Neonatal Hypernatremic Dehydration Safe Approach Retrospective Study","Retrospective analysis from a neonatal intensive care unit evaluated the prevalence, complications, and mortality of hypernatremic dehydration in term neonates. The study assessed how serum sodium correction rates within 48 hours related to short-term mortality and 6-month neurological outcomes, comparing severity based on admission sodium ranges. Among 4,280 neonates, 81 cases (1.8%) were identified. Correction rate thresholds and higher admission sodium were linked to death and/or convulsions, with convulsions emerging as the most common therapy complication. Management differences between sodium groups influenced developmental screening results.","What Is the Safe Approach for Neonatal Hypernatremic Dehydration?  \nA Retrospective Study From a Neonatal Intensive Care Unit  \nFatih Bolat, MD,* Mehmet Burhan Of laz, MD,Þ Ahmet Sami Gven, MD,þ Go¨ktu? ¨Ozdemir, MD,§ Demet Alaygut, MD,|| Melih Timuin Do?an, MD,§ Fu¨sun Dilara ˙la?asıo?lu, MD,þ¨Omer Cevit, MD,§ and Asım Gltekin, MD*  \nObjectives: The aims of this study were to evaluate the prevalence, complications, and mortality of hypernatremic dehydration in neonates and to compare the effect of correction rate at 48 hours on mortality and on neurological outcome in the short term.  \nMethods: This retrospective study was conducted between January 2007 and 2011 in the neonatal intensive care unit. Term neonates were included. The patients were grouped as follows: group 1 = 150 to 160 mmol/L, group 2 = 161 to 170 mmol/L and group 3 = 171 to 189 mmol/L. Results: Among 4280 neonates, 81 cases (1.8%) had hypernatremic dehydration. Groups 1, 2, and 3 consisted of 55, 23, and 3 patients, respectively. Mortality rates were as follows: 3.6%, 17.3%, and 66.6% . Mean serum sodium(Na) correction rates at 0to24hours and24to48hours were 0.48 T 0.2 versus 0.38 T 0.31 mmol/L per hour (group 1) and 0.49 T 0.21 versus 0.52 T 0.28 mmol/L per hour (group 2), respectively. In 32 patients (58.1%) from group 1 and in 13 patients (56.5%) from group 2, correction rate of 0.5 mmol/L per hour or less was achieved. Twenty-two patients developed convulsions, which was the most common complication during therapy. Serum Na greater than 160 mmol/L at admission (odds ratio, 1.9; 95% confidence interval, 1.3Y3.7) and serum Na correction rate of greater than 0.5 mmol/L per hour (odds ratio, 4.3; 95% confidence interval, 1.2Y6.5) were independent risk factors for death or convulsion. There was a significant difference between groups 1 and 2 in Denver Developmental Screening Test II results (64.1% vs 30.7 %, P = 0.001) .  \nConclusion: Hypernatremic dehydration is an important problem that should be managed properly to avoid adverse outcomes.  \nKey Words: term neonates, hypernatremic dehydration, management, complications  \n(Pediatr Emer Care 2013;29: 808Y813)  \nIn the neonatal period, dehydration that occurs as the result  \nof many problems is one of the most common causes of rehospitalization.1 According to the serum osmolality, dehydration is classified into 3 forms as hypernatremic, normonatremic, and hyponatremic dehydration. Hypernatremic type is a potentially lethal form because it adversely affects central nervous system, leading to devastating consequences such as intracranial hemorrhage, thrombosis, and even death.2,3 Recently, along with many other etiologies, early discharge and failure of breast-feeding are increasingly documented as major causes of hypernatremic dehydration (HD) .4Y6  \nFrom the Department of *Neonatology,†Pediatric Cardiology,‡Neurology,§Pediatrics, and ||Nephrology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.  \nDisclosure: The authors declare no conflict of interest.  \nReprints: Fatih Bolat, MD, Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, 58140, Sivas, Turkey (e-mail: [fatihbolat74@gmail.com](fatihbolat74@gmail.com)).  \nCopyright * 2013 by Lippincott Williams & Wilkins ISSN: 0749-5161  \nHigh serum sodium (Na) concentration, which is associated with diminished fluid or excessive Na intake, or excessive fluid loss, is usually caused by inadequate breast-milk feeding in otherwise healthy newborns. Adequate management improves the outcome. Given the lack of trials for determining the optimal therapy on the issue, HD is a challenging problem not only for the emergency department physicians but also for the pediatricians/ neonatologists.7,8  \nThe aims of our study were to evaluate the prevalence, complications, and mortality of HD and to compare the effect of hypernatremia correction rate at 48 hours on mortality and on neurological outcome at 6 months in hypernatremic n","cbCaicSyHCdAMx6U","https://ap.wps.com/l/cbCaicSyHCdAMx6U","pdf",968155,4,1,6,"English","en",105,"# Objectives\n# Methods\n## Study design and participants\n## Grouping and treatment\n# Results\n# Conclusion\n# Key Definitions","[{\"question\":\"What was the study’s main objective in evaluating neonatal hypernatremic dehydration?\",\"answer\":\"The study evaluated prevalence, complications, and mortality in neonates, and compared the effect of the 48-hour sodium correction rate on mortality and short-term neurological outcome.\"},{\"question\":\"How were patients grouped for analysis based on admission serum sodium levels?\",\"answer\":\"Patients were grouped into three categories: 150–160 mmol/L, 161–170 mmol/L, and 171–189 mmol/L, based on serum sodium at admission.\"},{\"question\":\"Which factors were independent risk factors for death or convulsions?\",\"answer\":\"Higher serum sodium at admission (\\u003e160 mmol/L) and a serum sodium correction rate greater than 0.5 mmol/L per hour were independent risk factors for death or convulsion.\"}]",1783544879,15,{"code":4,"msg":31,"data":32},"ok",{"site_id":25,"language":24,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"neonatal-hypernatremic-dehydration-safe-approach-retrospective-study","",{"@graph":36,"@context":85},[37,53,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":20},"https://docshare.wps.com/document/neonatal-hypernatremic-dehydration-safe-approach-retrospective-study/46508/",{"url":52,"name":13,"@type":54,"author":55,"headline":13,"publisher":57,"fileFormat":60,"inLanguage":24,"description":14,"dateModified":61,"datePublished":62,"encodingFormat":60,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":56},"Person",{"url":41,"name":58,"@type":59},"DocShare","Organization","application/pdf","2026-07-16","2026-07-08",true,{"@type":65,"interactionType":66,"userInteractionCount":20},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"What was the study’s main objective in evaluating neonatal hypernatremic dehydration?","Question",{"text":75,"@type":76},"The study evaluated prevalence, complications, and mortality in neonates, and compared the effect of the 48-hour sodium correction rate on mortality and short-term neurological outcome.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"How were patients grouped for analysis based on admission serum sodium levels?",{"text":80,"@type":76},"Patients were grouped into three categories: 150–160 mmol/L, 161–170 mmol/L, and 171–189 mmol/L, based on serum sodium at admission.",{"name":82,"@type":73,"acceptedAnswer":83},"Which factors were independent risk factors for death or convulsions?",{"text":84,"@type":76},"Higher serum sodium at admission (>160 mmol/L) and a serum sodium correction rate greater than 0.5 mmol/L per hour were independent risk factors for death or 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