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Building on growing evidence that individual NEKs contribute to malignancies and other disorders, this review synthesizes current knowledge and establishes a framework for studying NEK roles in cancer. It evaluates associations between NEK1–NEK11 mRNA expression and overall survival across cancers using KMPlotter and identifies NEK mutations across tissues via COSMIC, indicating tissue-dependent tumor-suppressive or tumor-promoting effects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nek-family-review-and-correlations-with-patient-survival-outcomes-in-various-cancer-types/379870/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nek-family-review-and-correlations-with-patient-survival-outcomes-in-various-cancer-types/379870.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are NEKs and what cellular processes do they regulate?","Question",{"text":112,"@type":113},"NEKs are NIMA-related serine/threonine kinases. They participate in cell-cycle regulation, DNA damage repair response, apoptosis, and microtubule organization.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the review connect NEK gene expression with patient survival?",{"text":117,"@type":113},"The review evaluates associations between NEK1–NEK11 mRNA expression and overall survival across various cancers using the Kaplan–Meier Online Tool (KMPlotter).",{"name":119,"@type":110,"acceptedAnswer":120},"How are NEK mutations in different cancers identified?",{"text":121,"@type":113},"NEK family mutations are identified using the COSMIC database, allowing mutation mapping across cancers of different tissues.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379870,1790528035,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","cancers   \nReview  \nNEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types  \nKhoa Nguyen 1, *, Julia Boehling 1, Minh N. Tran 1, Thomas Cheng 1, Andrew Rivera 1, Bridgette M. Collins-Burow 1, Sean B. Lee 2, David H. Drewry 3 and Matthew E. Burow 1, *  \nCitation: Nguyen, K.; Boehling, J.; Tran, M.N.; Cheng, T.; Rivera, A.; Collins-Burow, B.M.; Lee, S.B.; Drewry, D.H.; Burow, M.E. NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types. Cancers 2023, 15, 2067 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15072067  \nAcademic Editor: Janeen Trembley  \nReceived: 28 January 2023  \nRevised: 22 March 2023  \nAccepted: 29 March 2023  \nPublished: 30 March 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA  \n2 Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA  \n3 UNC Lineberger Comprehensive Cancer Center, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA  \n* Correspondence: [knguyen11@tulane.edu](knguyen11@tulane.edu) (K.N.); [mburow@tulane.edu](mburow@tulane.edu) (M.E.B.)  \nSimple Summary: Kinases are biomolecules that control cellular reactions essential for life. Disruptions in kinase expression and activity lead to the development of diseases such as cancer. A great deal of funding and scientific effort has been poured into kinase research, leading to great advancement. For example, a groundbreaking discovery was the development of imatinib, a kinase inhibitor, for the treatment of CML. Despite these discoveries, a large portion of the human kinome remains understudied. This review seeks to address this issue by discussing the understudied NEK family of kinases. We do this by discussing existing studies, analyzing correlations between the expression of NEK genes and patient survival outcomes in different cancers, discussing NEK mutations found indifferent cancer tissue types, and covering potential funding opportunities for those interested in pursuing NEK research.  \nAbstract: The Never in Mitosis Gene A (NIMA)–related kinases (NEKs) are a group of serine/threonine kinases that are involved in a wide array of cellular processes including cell cycle regulation, DNA damage repair response (DDR), apoptosis, and microtubule organization. Recent studies have identified the involvement of NEK family members in various diseases such as autoimmune disorders, malignancies, and developmental defects. Despite the existing literature exemplifying the importance of the NEK family of kinases, this family of protein kinases remains understudied. This report seeks to provide a foundation for investigating the role of different NEKs in malignancies. We do this by evaluating the 11 NEK family kinase gene expression associations with patients' overall survival (OS) from various cancers using the Kaplan–Meier Online Tool (KMPlotter) to correlate the relationship between mRNA expression of NEK1-11 in various cancers and patient survival. Furthermore, we use the Catalog of Somatic Mutations in Cancer (COSMIC) database to identify NEK family mutations in cancers of different tissues. Overall, the data suggest that the NEK family has varying associations with patient survival in different cancers with tumor-suppressive and tumor-promoting effects being tissue-dependent.  \nKeywords: NEK family; kinase; cancer signaling; KMPlot; cosmic mutation; bioinformatics; illuminating the druggable genome; understudied kinase; dark kinome  \n1. ","cbCaigoXzgGdwkkj","https://ap.wps.com/l/cbCaigoXzgGdwkkj","pdf",327291,18,"English","# Simple Summary\n# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"What are NEKs and what cellular processes do they regulate?\",\"answer\":\"NEKs are NIMA-related serine/threonine kinases. They participate in cell-cycle regulation, DNA damage repair response, apoptosis, and microtubule organization.\"},{\"question\":\"How does the review connect NEK gene expression with patient survival?\",\"answer\":\"The review evaluates associations between NEK1–NEK11 mRNA expression and overall survival across various cancers using the Kaplan–Meier Online Tool (KMPlotter).\"},{\"question\":\"How are NEK mutations in different cancers identified?\",\"answer\":\"NEK family mutations are identified using the COSMIC database, allowing mutation mapping across cancers of different tissues.\"}]","NEK Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types | PDF",1790237826,45]