[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328377-105":59,"doc-detail-328377-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","navigating-therapeutic-strategies-hpv-classification-in-head-and-neck-cancer","Navigating therapeutic strategies: HPV classification in head and neck cancer","","The review examines how human papillomavirus (HPV) contributes to head and neck cancer and how viral genome status shapes treatment response. It explains that HPV integration into host DNA versus episomal persistence influences viral gene expression and the level of DNA damage, affecting clinical outcomes. The article highlights that patients with fully integrated HPV often experience the worst prognosis due to reduced viral gene expression and limited cytotoxic T-cell infiltration, emphasizing the need to consider integration status beyond HPV positivity alone.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/navigating-therapeutic-strategies-hpv-classification-in-head-and-neck-cancer/328377/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/navigating-therapeutic-strategies-hpv-classification-in-head-and-neck-cancer/328377.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why does HPV integration status matter for head and neck cancer outcomes?","Question",{"text":112,"@type":113},"Integration status influences viral gene expression and the degree of DNA damage, which correlates with clinical outcomes. Fully integrated HPV tumors are associated with poorer prognosis than other HPV statuses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the main clinical limitation of current HPV testing mentioned in the review?",{"text":117,"@type":113},"The review notes that clinic applications often rely on testing HPV positivity alone, without considering whether HPV is integrated, episomal, or mixed.",{"name":119,"@type":110,"acceptedAnswer":120},"Which patient group is reported to have the worst clinical outcomes in HPV-positive head and neck cancer?",{"text":121,"@type":113},"Patients with head and neck cancers showing fully integrated HPV present the worst clinical outcomes, attributed to lowered viral gene expression and reduced infiltration of cytotoxic T cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328377,1790804340,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","[www.nature.com/bjc](www.nature.com/bjc British)[ British](www.nature.com/bjc British) Journal of Cancer  \nREVIEW ARTICLE OPEN   \nTranslational Therapeutics  \nNavigating therapeutic strategies: HPV classification in head and neck cancer  \nHossein Tabatabaeian1, Yuchen Bai1, Ruihong Huang 1, Akhilanand Chaurasia 2 and Charbel Darido 1,3 ✉  \n© Crown 2024  \n|  |  |  |\n| --- | --- | --- |\n|  | The World Health Organisation recognised human papillomavirus (HPV) as the cause of multiple cancers, including head and neck cancers. HPV is a double-stranded DNA virus, and its viral gene expression can be controlled after infection by cellular and viral promoters. In cancer cells, the HPV genome is detected as either integrated into the host genome, episomal (extrachromosomal), ora mixture of integrated and episomal. Viral integration requires the breakage of both viral and host DNA, and the integration rate correlates with the level of DNA damage. Interestingly, patients with HPV-positive head and neck cancers generally have a good prognosis except for a group of patients with fully integrated HPV who show worst clinical outcomes. Those patients present with lowered expression of viral genes and limited infiltration of cytotoxic T cells. An impediment to effective therapy applications in the clinic is the sole testing for HPV positivity without considering the HPV integration status. This review will discuss HPV integration asa potential determinant of response to therapies in head and neck cancers and highlight to the field a novel therapeutic avenue |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| that would reduce the cancer burden and improve patient survival. |  |  |\n|  | British Journal of Cancer (2024) 131:220–230; [https://doi.org/10.1038/s41416-024-02655-1](https://doi.org/10.1038/s41416-024-02655-1) |  |\n|  |  |  |\n\nBACKGROUND  \nHead and neck squamous cell carcinomas (HNSCC) is the main type of malignancy of the head and neck region and the seventh most common cancer worldwide accounting for nearly 1 million new cases, and 470,000 deaths in 2020 [1] . The incidence of HNSCC continues to rise and is anticipated to reach an annual incidence rate of 1.37 million new cases by 2040 [2, 3] .  \nHNSCC originates from the mucosal epithelium of the lips, oral cavity, salivary glands, larynx and pharynx. The major external risk factors associated with the incidence of HNSCC are exposure to excessive alcohol consumption, tobacco-related cancer-causing agents, or both. Along with these risk factors, intrinsic genetic, transcriptional and post-translational changes such as the expression and/or function of Fanconi Anaemia Complementation Group (FANC) [4], Grainyhead-like 3 (GRHL3) [5], Filaggrin (FLG) [6], and cellular localisation of Y-box binding protein 1 (YBX1) [7] impact HNSCC development. On the other hand, oropharyngeal squamous cell carcinoma (SCC) tumours are associated with prior infection with oncogenic strains of human papillomavirus (HPV), whereas >70% of oropharyngeal cancers are HPV-positive. Studies reveal a global trend of rising HPV-related cancers and declining HPV-unrelated subsites. Over the next two decades, the majority of HNSCC cases are expected to be HPV-positive, with some countries like the UK experiencing a higher incidence of oropharyngeal cancer than oral cavity cancer [8, 9] .  \nIn this review, we summarise the role of HPV infection in head and neck cancer development, with a focus on chromosomal abnormalities and the viral integration process. We also highlight how the integration status affects the patients’ therapeutic outcomes.  \nHPV: A VIRUS CAUSING CANCER IN HUMANS  \nHPV is the most prevalent sexually transmitted infection worldwide that has significant social implications. Both sexually active women and men are susceptible to HPV infection [10], although not all individuals will develop associated health issues. HPV infection remains widespread worldw","cbCaivrlHezidu2V","https://ap.wps.com/l/cbCaivrlHezidu2V","pdf",1814785,11,"English","# Background\n## HPV: a virus causing cancer in humans\n# HPV classification and genome integration\n## Therapeutic implications of integration status","[{\"question\":\"Why does HPV integration status matter for head and neck cancer outcomes?\",\"answer\":\"Integration status influences viral gene expression and the degree of DNA damage, which correlates with clinical outcomes. Fully integrated HPV tumors are associated with poorer prognosis than other HPV statuses.\"},{\"question\":\"What is the main clinical limitation of current HPV testing mentioned in the review?\",\"answer\":\"The review notes that clinic applications often rely on testing HPV positivity alone, without considering whether HPV is integrated, episomal, or mixed.\"},{\"question\":\"Which patient group is reported to have the worst clinical outcomes in HPV-positive head and neck cancer?\",\"answer\":\"Patients with head and neck cancers showing fully integrated HPV present the worst clinical outcomes, attributed to lowered viral gene expression and reduced infiltration of cytotoxic T cells.\"}]","Navigating therapeutic strategies: HPV classification in head and neck cancer | PDF",1789979479,28]