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Autophagy, crucial for cellular homeostasis, can support survival or death, and its cancer role is dual: early suppression can contrast with later promotion that contributes to chemoresistance. Dysregulated autophagy-related genes and epigenetic control, including non-coding RNAs, shape autophagy flux, treatment response, and tumor progression.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/navigating-the-autophagic-landscape-epigenetic-modulation-in-gastrointestinal-cancer/375730/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/navigating-the-autophagic-landscape-epigenetic-modulation-in-gastrointestinal-cancer/375730.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main focus of this editorial?","Question",{"text":113,"@type":114},"It analyzes the interplay between epigenetic regulation and autophagy in gastrointestinal diseases, with particular attention to cancer.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is autophagy described as having a dual role in cancer?",{"text":118,"@type":114},"The editorial notes that autophagy can suppress early tumor progression yet later promote processes linked to chemoresistance.",{"name":120,"@type":111,"acceptedAnswer":121},"How do epigenetic mechanisms and non-coding RNAs relate to autophagy and treatment outcomes?",{"text":122,"@type":114},"Epigenetic modifications, including non-coding RNAs, are presented as regulatory drivers of autophagy flux, influencing treatment responses and tumor progression.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},375730,1790611580,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":46},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2024 August 21; 30(31): 3628-3634  \nDOI: 10.3748/wjg.v30.i31.3628 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nEDITORIAL  \nNavigating the autophagic landscape: Epigenetic modulation in gastrointestinal cancer  \nDavide Ramoni, Federico Carbone, Fabrizio Montecucco  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C  \nNovelty: Grade B  \nCreativity or Innovation: Grade B  \nScientific Significance: Grade C  \nP-Reviewer: Yang JB  \nReceived: March 20, 2024  \nRevised: July 18, 2024  \nAccepted: July 23, 2024  \nPublished online: August 21, 2024  \nProcessing time: 145 Days and 13.3 Hours  \nDavide Ramoni, Department of Internal Medicine, University of Genoa, Genoa 16132, Italy  \nFederico Carbone, Fabrizio Montecucco, Department of Internal Medicine, University of Genoa and IRCSS Policlinico San Martino, Genoa 16132, Italy  \nCorresponding author: Fabrizio Montecucco, MD, PhD, Full Professor, Department of Internal Medicine and Medical Specialties, University of Genoa and IRCSS Ospedale Policlinico San Martino, 6 Viale Benedetto XV, Genoa 16132, [Italy.](Italy. fabrizio.montecucco@unige.it)[ fabrizio.montecucco@unige.it](Italy. fabrizio.montecucco@unige.it)  \nAbstract  \nThis editorial comments on the manuscript by Chang et al, focusing on the still elusive interplay between epigenetic regulation and autophagy in gastrointestinal diseases, particularly cancer. Autophagy, essential for cellular homeostasis, exhibits diverse functions ranging from cell survival to death, and is particularly implicated in physiological gastrointestinal cell functions. However, its role in pathological backgrounds remains intricate and context-dependent. Studies underscore the dual nature of autophagy in cancer, where its early suppressive effects in early stages are juxtaposed with its later promotion, contributing to chemoresistance. This discrepancy is attributed to the dysregulation of autophagy-related genes and their intricate involvement in cellular processes. Epigenetic modifications and regulations of gene expression, including non-coding RNAs (ncRNAs), emerge as critical players in exerting regulatory control over autophagy flux, influencing treatment responses and tumor progression. Targeting epigenetic mechanisms and improving strategies involving the inhibition or induction of autophagy through pharmacological or genetic means present potential avenues to sensitize tumor cells to chemotherapy. Additionally, nanocarrier-based delivery of ncRNAs offers innovative therapeutic approaches. Understanding the intricate interaction between autophagy and ncRNA regula-tion opens avenues for the development of targeted therapies, thereby improving the prognosis of gastrointestinal malignancies with poor outcomes.  \nKey Words: Epigenetic regulation; Autophagy; Gastrointestinal cancer; Non-coding RNAs; Target therapies  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 3628 August 21, 2024  Volume 30  Issue 31   \nRamoni D et al. Epigenetic autophagy regulation in gastrointestinal cancer  \nCore Tip: Understanding the intricate interplay between autophagy, epigenetics, and non-coding RNA (ncRNA) regulation in gastrointestinal (GI) cancers is crucial for devising effective therapeutic interventions. Autophagy exhibits a dual role in cancer progression, impacting treatment response rates, and its modulation through epigenetic alterations and ncRNA regulation offers promising avenues for targeted therapies. Developing strategies to manipulate autophagy, particularly via epigenetic mechanisms and nanocarrier-based ncRN","cbCaidHW8qm4TAyj","https://ap.wps.com/l/cbCaidHW8qm4TAyj","pdf",7879989,"English","# Abstract\n# Core Tip\n# Introduction","[{\"question\":\"What is the main focus of this editorial?\",\"answer\":\"It analyzes the interplay between epigenetic regulation and autophagy in gastrointestinal diseases, with particular attention to cancer.\"},{\"question\":\"Why is autophagy described as having a dual role in cancer?\",\"answer\":\"The editorial notes that autophagy can suppress early tumor progression yet later promote processes linked to chemoresistance.\"},{\"question\":\"How do epigenetic mechanisms and non-coding RNAs relate to autophagy and treatment outcomes?\",\"answer\":\"Epigenetic modifications, including non-coding RNAs, are presented as regulatory drivers of autophagy flux, influencing treatment responses and tumor progression.\"}]","Navigating the autophagic landscape - Epigenetic modulation in gastrointestinal cancer | PDF",1790215931]