[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-326907-105":3,"doc-detail-326907-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","natural-compounds-in-non-melanoma-skin-cancer-prevention-and-treatment","Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment","","The review addresses the growing global burden of non-melanoma skin cancer (NMSC) and the limitations and side effects of existing therapies that negatively affect quality of life. It highlights natural compounds as safer, more tolerable candidates, with anti-cancer potential across multiple mechanisms. Emphasis includes modulation of oxidative-stress pathways and targeting key signaling networks to support apoptosis, suppress proliferation, and reduce metastasis. Coverage spans anti-carcinogenic chemotherapies and chemoprevention, including polyphenols, flavonoids, vitamins, alkaloids, terpenoids, isothiocyanates, cannabinoids, carotenoids, and ceramides.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/natural-compounds-in-non-melanoma-skin-cancer-prevention-and-treatment/326907/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/natural-compounds-in-non-melanoma-skin-cancer-prevention-and-treatment/326907.png","ImageObject",300,407,{"name":42,"@type":43},"Patrick","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are alternative approaches needed for non-melanoma skin cancer treatment?","Question",{"text":63,"@type":64},"The review links the rising occurrence of NMSC and the adverse effects of available treatments to reduced quality of life, motivating approaches with better tolerance and fewer side effects.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do natural compounds contribute to anti-cancer effects in NMSC?",{"text":68,"@type":64},"Natural compounds are described as exerting anti-carcinogenic actions through multiple pathways, including potentiating apoptosis, inhibiting cell proliferation, and suppressing metastasis.",{"name":70,"@type":61,"acceptedAnswer":71},"Which signaling pathways are highlighted as disrupted by ultraviolet exposure?",{"text":72,"@type":64},"Ultraviolet effects are presented as primarily mediated by oxidative stress that disrupts pathways such as NF-κB/p65, MAPK, JAK/STAT, and Nrf2.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},326907,1790111587,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470",7,"molecules   \nReview  \nNatural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment  \nSzymon Kowalski 1,†, Julia Karska 2,†, Maciej Tota 1, Katarzyna Skinderowicz 1, Julita Kulbacka 3,4, * and Małgorzata Dra˛g-Zalesi ´nska 5  \nCitation: Kowalski, S.; Karska, J.; Tota, M.; Skinderowicz, K.; Kulbacka, J.; Dra˛g-Zalesi ´nska, M. Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment.  \nMolecules 2024, 29, 728. [https://](https://)[ ](https://)[doi.org/10.3390/molecules29030728](doi.org/10.3390/molecules29030728)  \nAcademic Editor: Andrzej Slominski  \nReceived: 14 December 2023  \nRevised: 27 January 2024  \nAccepted: 1 February 2024  \nPublished: 4 February 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Faculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland; [szymon.kowalski@student.umw.edu.pl](szymon.kowalski@student.umw.edu.pl) (S.K.); [maciej.tota@student.umw.edu.pl](maciej.tota@student.umw.edu.pl) (M.T.); [katarzyna.skinderowicz@student.umw.edu.pl](katarzyna.skinderowicz@student.umw.edu.pl) (K.S.)  \n2 Department of Psychiatry, Wroclaw Medical University, Pasteura 10, 50-367 Wroclaw, Poland; [julia.karska@student.umw.edu.pl](julia.karska@student.umw.edu.pl)  \n3 Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211A, 50-556 Wroclaw, Poland  \n4 Department of Immunology and Bioelectrochemistry, State Research Institute Centre for Innovative Medicine, Santariškiu˛ 5, 08410 Vilnius, Lithuania  \n5 Department of Human Morphology and Embryology, Division of Histology and Embryology, Faculty of Medicine, Wroclaw Medical University, T. Chalubi ´nskiego 6a, 50-368 Wroclaw, Poland; [malgorzata.drag-zalesinska@umw.edu.pl](malgorzata.drag-zalesinska@umw.edu.pl)  \n* [Correspondence: julita.kulbacka@umw.edu.pl](Correspondence: julita.kulbacka@umw.edu.pl)[ ](Correspondence: julita.kulbacka@umw.edu.pl)† These authors contributed equally to this work.  \nAbstract: The elevated occurrence of non-melanoma skin cancer (NMSC) and the adverse effects associated with available treatments adversely impact the quality of life in multiple dimensions. In connection with this, there is a necessity for alternative approaches characterized by increased tolerance and lower side effects. Natural compounds could be employed due to their safety profile and effectiveness for inflammatory and neoplastic skin diseases. These anti-cancer drugs are often derived from natural sources such as marine, zoonotic, and botanical origins. Natural compounds should exhibit anti-carcinogenic actions through various pathways, influencing apoptosis potentiation, cell proliferation inhibition, and metastasis suppression. This review provides an overview of natural compounds used in cancer chemotherapies, chemoprevention, and promotion of skin regeneration, including polyphenolic compounds, flavonoids, vitamins, alkaloids, terpenoids, isothiocyanates, cannabinoids, carotenoids, and ceramides.  \nKeywords: natural compounds; natural agents; non-melanoma skin cancer; NMSC  \n1. Introduction  \nCutaneous malignancies represent the most prevalent category of cancers diagnosed worldwide, with an estimated 1.5 million new cases projected in 2020 . Within this estimate, approximately 325,000 new incidences of melanoma and 1.2 million non-melanoma skin cancers (NMSC) were reported by the International Agency for Research on Cancer of the World Health Organization (WHO) . The death rates reached then 64,000 and 57,000, respectively. Notably, in most regions worldwide, skin cancer manifests more frequently in men than in women, according to the WHO.  \nBoth melanoma and NMSC are ","cbCaitQcZdF2KETf","https://ap.wps.com/l/cbCaitQcZdF2KETf","pdf",4007933,37,"English","# Introduction\n## Global burden of NMSC\n## Role of UV radiation and molecular pathways\n## Contributing risk factors\n## NMSC types and tumor biology","[{\"question\":\"Why are alternative approaches needed for non-melanoma skin cancer treatment?\",\"answer\":\"The review links the rising occurrence of NMSC and the adverse effects of available treatments to reduced quality of life, motivating approaches with better tolerance and fewer side effects.\"},{\"question\":\"How do natural compounds contribute to anti-cancer effects in NMSC?\",\"answer\":\"Natural compounds are described as exerting anti-carcinogenic actions through multiple pathways, including potentiating apoptosis, inhibiting cell proliferation, and suppressing metastasis.\"},{\"question\":\"Which signaling pathways are highlighted as disrupted by ultraviolet exposure?\",\"answer\":\"Ultraviolet effects are presented as primarily mediated by oxidative stress that disrupts pathways such as NF-κB/p65, MAPK, JAK/STAT, and Nrf2.\"}]","Natural Compounds in Non-Melanoma Skin Cancer: Prevention and Treatment | PDF",1789975727,93,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,126,131,136,139,143],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":124,"slug":125},40,"healthcare",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":129,"slug":130},8,"Research & Report",30,"research-report",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":133,"show_sort_weight":134,"slug":135},9,"Religion & Spirituality",20,"religion-spirituality",{"id":134,"doc_module":4,"doc_module_name":25,"category_name":137,"show_sort_weight":134,"slug":138},"World Cup","world-cup",{"id":140,"doc_module":4,"doc_module_name":25,"category_name":141,"show_sort_weight":140,"slug":142},10,"Lifestyle","lifestyle",{"id":144,"doc_module":4,"doc_module_name":25,"category_name":145,"show_sort_weight":114,"slug":146},19,"General","general"]