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Department of Biochemistry, Faculty of Science, Ege University, Izmir 35040, Turkey  \n2. Institute of Molecular Biology & Biotechnologies, Ministry of Science and Education Republic of Azerbaijan, 11 Izzat Nabiyev, AZ1073 Baku, Azerbaijan  \n3. Department of Chemistry and Pharmacy, Physical Chemistry I and ICMM, Friedrich-Alexander University of Erlangen─Nuremberg, Egerlandstrasse 3, D-91058 Erlangen, Germany  \n4. Department of Biomedical Sciences, University of Lausanne, Rue du Bugnon 7, 1005 Lausanne, Switzerland  \n5. Swiss Centre for Applied Human Toxicology (SCAHT), University of Basel, Missionsstrasse 64, 4055 Basel, Switzerland  \n6. Molecular Nutrition and Human Physiology Laboratory, Department of Food Engineering, İzmir Institute of Technology, 35430 Urla, İzmir, Turkey  \n7. Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran  \n8. Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Silesian University of Technology, B. Krzywoustego 4, 44-100, Gliwice, Poland  \n9. Department of Pharmaceutical Toxicology, Yeditepe University Faculty of Pharmacy, Istanbul, Turkey  \n10. Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran  \n11. Department of Biophysics and Biochemistry, Baku State University, Baku, Azerbaijan  \n12. Institute of Radiation Problems, National Academy of Sciences of Azerbaijan, Baku, Azerbaijan  \n􀀍 Corresponding authors: [ahmadian.elham@yahoo.com](ahmadian.elham@yahoo.com), [dawid.janas@polsl.pl](dawid.janas@polsl.pl), [davaran@tbzmed.ac.ir](davaran@tbzmed.ac.ir)  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2022.07.28; Accepted: 2022.11.10; Published: 2023.03.05  \nAbstract  \nNanomaterials have been extensively studied in cancer therapy as vectors that may improve drug delivery. Such vectors not only bring numerous advantages such as stability, biocompatibility, and cellular uptake but have also been shown to overcome some cancer-related resistances. Nanocarrier can deliver the drug more precisely to the specific organ while improving its pharmacokinetics, thereby avoiding secondary adverse effects on the not target tissue. Between these nanovectors, diverse material types can be discerned, such as liposomes, dendrimers, carbon nanostructures, nanoparticles, nanowires, etc., each of which offers different opportunities for cancer therapy. In this review, a broad spectrum of nanovectors is analyzed for application in multimodal cancer therapy and diagnostics in terms of mode of action and pharmacokinetics. Advantages and inconveniences of promising nanovectors, including gold nanostructures, SPIONs, semiconducting quantum dots, various nanostructures, phospholipid-based liposomes, dendrimers, polymeric micelles, extracellular and exome vesicles are summarized. The article is concluded with a future outlook on this promising field.  \nKeywords: Nanoparticles, nanovectors, cancer, drug delivery, nanomaterials  \nIntroduction  \nThe tremendous growth in the field of nanotechnology has dramatically impacted biomedicine and drug delivery. For example, the ability to target a payload of active pharmaceutical ingredients (API) to a specific location at a proper concentration and time has driven the development of new cancer treatments (1) with the use of so-called nanocarriers or nanovectors. Such units, w","cbCainhskkS5JOjy","https://ap.wps.com/l/cbCainhskkS5JOjy","pdf",5015417,22,"English","# Abstract\n# Introduction\n# Nanovectors in cancer therapy","[{\"question\":\"What role do nanovectors play in cancer therapy?\",\"answer\":\"Nanovectors serve as delivery vectors for therapeutic agents, improving drug delivery precision, stability, biocompatibility, and cellular uptake. They also can help address certain cancer-related resistances.\"},{\"question\":\"How do nanocarriers improve drug delivery and reduce side effects?\",\"answer\":\"Nanocarriers deliver drugs more precisely to target organs and improve pharmacokinetics, which helps avoid secondary adverse effects on non-target tissues. Their nanometer scale supports controlled distribution over time.\"},{\"question\":\"Which types of nanovectors are discussed in the review?\",\"answer\":\"The review covers multiple material classes including liposomes, dendrimers, carbon nanostructures, nanoparticles, nanowires, and other nanostructures such as gold nanostructures, SPIONs, and semiconducting quantum dots.\"}]","Natural and synthetic nanovectors for cancer therapy - Review | PDF",1790560476,55]