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The document explains how to analyze valid whole effluent toxicity (WET) test data using traditional hypothesis testing to support NPDES reasonable potential and permit compliance determinations. It clarifies that the publication is not a permit, regulation, or legally binding requirement, and it emphasizes that it does not change EPA WET test methods codified in 40 CFR Part 136.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/national-pollutant-discharge-elimination-system-test-of-significant-toxicity-implementation-document-june-2010/437189/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/national-pollutant-discharge-elimination-system-test-of-significant-toxicity-implementation-document-june-2010/437189.png","ImageObject",300,407,{"name":92,"@type":93},"percent12345","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the Test of Significant Toxicity (TST) approach used for?","Question",{"text":112,"@type":113},"The TST approach is designed to analyze whole effluent toxicity (WET) test data using hypothesis testing techniques to support NPDES reasonable potential and permit compliance determinations.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Does the implementation document change EPA’s WET test methods in 40 CFR Part 136?",{"text":117,"@type":113},"No. The document states that it does not result in changes to EPA’s WET test methods promulgated at Title 40 of the Code of Federal Regulations Part 136.",{"name":119,"@type":110,"acceptedAnswer":120},"Is this document legally binding for permits, regulations, or testing requirements?",{"text":121,"@type":113},"No. The notice and disclaimer explain that it does not substitute for the Clean Water Act, an NPDES permit, or applicable EPA/state regulations, and it cannot impose legally binding requirements on EPA, states, permittees, or laboratories.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},437189,1790763157,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099529851338,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","United States Office of Wastewater EPA 833-R-10-003  \nEnvironmental Management (June/2010)  \nAgency (4203M)  [http://www.epa.gov/npdes/permitbasics](http://www.epa.gov/npdes/permitbasics)  \nNational  \nPollutant Discharge Elimination System  \nTest of Significant Toxicity Implementation Document  \nJune 2010  \nNATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM TEST OF SIGNIFICANT TOXICITY  \nIMPLEMENTATION DOCUMENT  \nAn Additional Whole Effluent Toxicity  \nStatistical Approach for Analyzing  \nAcute and Chronic Test Data  \nU.S. Environmental Protection Agency  \nOffice of Wastewater Management  \nWater Permits Division  \n1200 Pennsylvania Avenue, NW  \nMail Code 4203M  \nEPA East – Room 7135  \nWashington, DC 20460  \nJune, 2010  \nNOTICE AND DISCLAIMER  \nThis document provides the basis for implementing the Test of Significant Toxicity (TST) approach under the National Pollutant Discharge Elimination System (NPDES) for permitting authorities (states and Regions) and persons interested in analyzing whole effluent toxicity (WET) test data using the traditional hypothesis testing approach as part of the NPDES Program under the Clean Water Act (CWA) . This document describes what the U.S. Environmental Protection Agency (EPA) believes is another statistical option to analyze valid WET test data for NPDES WET reasonable potential and permit compliance determinations. The document does not, however, substitute for the CWA, an NPDES permit, or EPA or state regulations applicable to permits or WET testing; nor is this document a permit or a regulation itself. The TST approach does not result in changes to EPA’s WET test methods promulgated at Title 40 of the Code of Federal Regulations Part 136. The document does not and cannot impose any legally binding requirements on EPA, states, NPDES permittees, or laboratories conducting or using WET testing for permittees (or for states in evaluating ambient water quality) . EPA could revise this document without public notice to reflect changes in EPA policy and guidance. Finally, mention of any trade names, products, or services is not and should not be interpreted as conveying official EPA approval, endorsement, or recommendation.  \nCONTENTS  \nEXECUTIVE SUMMARY .............................................................................................................v  \nACRONYMS AND ABBREVIATIONS ...................................................................................... xi  \nGLOSSARY ................................................................................................................................ xiii  \n1.0 INTRODUCTION ............................................................................................................... 1  \n1.1 Terminology and Concepts ............................................................................................. 1  \n1.2 Background on the TST Approach ................................................................................. 3  \n2.0 TST METHODOLOGY ...................................................................................................... 5  \n2.1 Regulatory Management Decisions for the TST Approach............................................ 5  \n2.2 Setting the Test Method-Specific Alpha Level............................................................... 6  \n3.0 USING THE TST APPROACH IN WET DATA ANALYSES ......................................... 9  \n3.1 Summary of Test Method-Specific Alpha Values .......................................................... 9  \n3.2 Calculating Statistics for Valid WET Data Using the TST Approach.......................... 10  \n4.0 IMPLEMENTING THE TST APPROACH IN WET NPDES PERMITS ....................... 13  \n4.1 Reasonable Potential (RP) WET Analysis.................................................................... 13  \n4.2 NPDES WET Permit Limits ......................................................................................... 14  \n5.0 RECOMMENDATIONS FOR NPDES IMPLEMENTATIO","cbCaitnfhv8VuCtY","https://ap.wps.com/l/cbCaitnfhv8VuCtY","pdf",755087,73,"English","# Executive Summary\n# Acronyms and Abbreviations\n# Glossary\n# 1.0 Introduction\n## 1.1 Terminology and Concepts\n## 1.2 Background on the TST Approach\n# 2.0 TST Methodology\n## 2.1 Regulatory Management Decisions for the TST Approach\n## 2.2 Setting the Test Method-Specific Alpha Level\n# 3.0 Using the TST Approach in WET Data Analyses\n## 3.1 Summary of Test Method-Specific Alpha Values\n## 3.2 Calculating Statistics for Valid WET Data Using the TST Approach\n# 4.0 Implementing the TST Approach in WET NPDES Permits\n## 4.1 Reasonable Potential (RP) WET Analysis\n## 4.2 NPDES WET Permit Limits\n# 5.0 Recommendations for NPDES Implementation of the TST Approach\n## 5.1 EPA Regions and NPDES States (Permitting Authorities)\n## 5.2 NPDES Permittees\n# 6.0 Summary of the TST Approach\n# 7.0 Literature Cited","[{\"question\":\"What is the Test of Significant Toxicity (TST) approach used for?\",\"answer\":\"The TST approach is designed to analyze whole effluent toxicity (WET) test data using hypothesis testing techniques to support NPDES reasonable potential and permit compliance determinations.\"},{\"question\":\"Does the implementation document change EPA’s WET test methods in 40 CFR Part 136?\",\"answer\":\"No. The document states that it does not result in changes to EPA’s WET test methods promulgated at Title 40 of the Code of Federal Regulations Part 136.\"},{\"question\":\"Is this document legally binding for permits, regulations, or testing requirements?\",\"answer\":\"No. The notice and disclaimer explain that it does not substitute for the Clean Water Act, an NPDES permit, or applicable EPA/state regulations, and it cannot impose legally binding requirements on EPA, states, permittees, or laboratories.\"}]","NATIONAL POLLUTANT DISCHARGE ELIMINATION SYSTEM - Test of Significant Toxicity Implementation Document - June 2010 | PDF",1790680568,184]