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Bioactive compounds from citrus fruits are discussed alongside naringenin’s ability to suppress cancer progression through multiple pleiotropic actions, including growth-factor/cytokine synthesis inhibition, cell-cycle regulation, and modulation of cellular signaling pathways. In vitro and in vivo data are described for carcinogen inactivation using pure naringenin, naringenin-loaded nanoparticles, and combination regimens.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/naringenin-as-potent-anticancer-phytocompound-in-breast-carcinoma-from-mechanistic-approach-to-nanoformulations-based-therapeutics/332181/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/naringenin-as-potent-anticancer-phytocompound-in-breast-carcinoma-from-mechanistic-approach-to-nanoformulations-based-therapeutics/332181.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What anticancer mechanisms does naringenin target in breast cancer?","Question",{"text":112,"@type":113},"The review highlights inhibition of growth factors and cytokines, suppression of cell-cycle progression, and modification of multiple cellular signaling pathways.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was naringenin tested for anticancer effects?",{"text":117,"@type":113},"Effects are demonstrated using in vitro and in vivo data, comparing pure naringenin, naringenin-loaded nanoparticles, and naringenin combined with anticancer agents.",{"name":119,"@type":110,"acceptedAnswer":120},"What are the key keywords describing the review’s focus?",{"text":121,"@type":113},"The stated keywords include cancer therapeutics, naringenin, phytochemicals, breast cancer, and nanoformulations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332181,1790919302,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","TYPE Review  \nPUBLISHED 18 June 2024  \nDOI 10.3389/fphar.2024.1406619  \nOPEN ACCESS  \nEDITED BY  \nSubhash Chander,  \nAmity University, India  \nREVIEWED BY  \nShatadal Ghosh,  \nUniversity of North Carolina at Chapel Hill, United States  \nNejat Duzgunes,  \nUniversity of the Pacific, United States Blanca Estela Garcia-Perez,  \nNational Polytechnic Institute (IPN), Mexico  \n*CORRESPONDENCE  \nMohd Saeed,  \n [mo.saeed@uoh.edu.sa](mo.saeed@uoh.edu.sa)[ ](mo.saeed@uoh.edu.sa)Fahad Khan,  \n [fahadintegralian@gmail.com](fahadintegralian@gmail.com)  \n†These authors have contributed equally to this work  \nRECEIVED 25 March 2024  \nACCEPTED 29 May 2024  \nPUBLISHED 18 June 2024  \nCITATION  \nElsori D, Pandey P, Ramniwas S, Kumar R, Lakhanpal S, Rab SO, Siddiqui S, Singh A, Saeed M and Khan F (2024), Naringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics.  \nFront. Pharmacol. 15:1406619 .  \ndoi: 10.3389/fphar.2024.1406619  \nCOPYRIGHT  \n© 2024 Elsori, Pandey, Ramniwas, Kumar, Lakhanpal, Rab, Siddiqui, Singh, Saeed and Khan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nNaringenin as potent anticancer phytocompound in breast carcinoma: from mechanistic approach to nanoformulations based therapeutics  \nDeena Elsori 1†, Pratibha Pandey 2†, Seema Ramniwas 3, Rahul Kumar 4, Sorabh Lakhanpal 5, Safia Obaidur Rab6,  \nSamra Siddiqui 7, Ajay Singh 8, Mohd Saeed 9* and Fahad Khan 10*  \n1Faculty of Resilience, Rabdan Academy, Abu Dhabi, United Arab Emirates, 2Centre of Research Impact and Outcome, Chitkara University, Rajpura, India, 3University Centre of Research and Development, University Institute of Biotechnology, Chandigarh University Gharuan, Mohali, India, 4Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, India, 5School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India, 6Department of Clinical Laboratory Sciences, College of Applied Medical Science, King Khalid University, Abha, Saudi Arabia, 7Department of Health Service Management, College of Public Health and Health Informatics, University of Ha ’ il, Ha’ il, Saudi Arabia, 8School of Applied and Life Sciences, Uttaranchal University, Dehradun, India, 9Department of Biology, College of Science, University of Hail, Ha’ il, Saudi Arabia, 10Center for Global Health Research Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, India  \nThe bioactive compounds present in citrus fruits are gaining broader acceptance in oncology. Numerous studies have deciphered naringenin ’s antioxidant and anticancer potential in human and animal studies. Naringenin (NGE) potentially suppresses cancer progression, thereby improving the health of cancer patients. The pleiotropic anticancer properties of naringenin include inhibition of the synthesis of growth factors and cytokines, inhibition of the cell cycle, and modification of several cellular signaling pathways. As an herbal remedy, naringenin has significant pharmacological properties, such as antiinflammatory, antioxidant, neuroprotective, hepatoprotective, and anti-cancer activities. The inactivation of carcinogens following treatment with pure naringenin, naringenin-loaded nanoparticles, and naringenin combined with anti-cancer agents was demonstrated by data in vitro and in vivo studies. These studies included colon cancer, lung neoplasms, breast cancer, leukemia and lymphoma, pancreatic cancer, prostate tumors, oral squamous cell carcinoma, liver cancer, brain tumors, skin cancer, cervical and o","cbCaia3tH9Jm6mHP","https://ap.wps.com/l/cbCaia3tH9Jm6mHP","pdf",1268648,15,"English","# KEYWORDS\n# 1 Introduction\n## Cancer as a global fatal disease\n## Pathological drivers and oxidative stress","[{\"question\":\"What anticancer mechanisms does naringenin target in breast cancer?\",\"answer\":\"The review highlights inhibition of growth factors and cytokines, suppression of cell-cycle progression, and modification of multiple cellular signaling pathways.\"},{\"question\":\"How was naringenin tested for anticancer effects?\",\"answer\":\"Effects are demonstrated using in vitro and in vivo data, comparing pure naringenin, naringenin-loaded nanoparticles, and naringenin combined with anticancer agents.\"},{\"question\":\"What are the key keywords describing the review’s focus?\",\"answer\":\"The stated keywords include cancer therapeutics, naringenin, phytochemicals, breast cancer, and nanoformulations.\"}]","Naringenin as potent anticancer phytocompound in breast carcinoma - from mechanistic approach to nanoformulations based therapeutics | PDF",1789997223,38]