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Conventional chemotherapy remains challenging and frequently ineffective, limiting treatment outcomes. Nanoparticles can potentially address these drawbacks by enabling earlier detection and monitoring of neoplastic changes, and by improving delivery of medicinal substances. The review summarizes skin cancer characteristics, epidemiology, and risk factors, and discusses liposomes, carbon nanotubes, metal and polymer nanoparticles, along with therapy challenges and performance-improvement prospects.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nanotechnology-as-a-promising-method-in-the-treatment-of-skin-cancer/330159/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nanotechnology-as-a-promising-method-in-the-treatment-of-skin-cancer/330159.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are conventional treatments for skin cancer often ineffective?","Question",{"text":112,"@type":113},"Treatment remains challenging and conventional chemotherapy plays a limited role, contributing to suboptimal outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can nanoparticles improve skin cancer management?",{"text":117,"@type":113},"Nanoparticles may enable early detection and monitoring of neoplastic changes and allow more accurate drug delivery to tumor sites, increasing therapeutic efficacy.",{"name":119,"@type":110,"acceptedAnswer":120},"Which nanomaterial types are discussed for treating skin cancer?",{"text":121,"@type":113},"The review describes applications of liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles, including polymeric nanocarriers and nanofibers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330159,1790195479,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Review  \nNanotechnology as a Promising Method in the Treatment of Skin Cancer  \nAngelika A. Adamus-Grabicka 1, Pawel Hikisz 2 and Joanna Sikora 1, *  \nCitation: Adamus-Grabicka, A.A.; Hikisz, P.; Sikora, J. Nanotechnology as a Promising Method in the Treatment of Skin Cancer. Int. J. Mol.  \nSci. 2024, 25, 2165. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms25042165](10.3390/ijms25042165)  \nAcademic Editor: Urszula Bazylinska  \nReceived: 20 January 2024  \nRevised: 6 February 2024  \nAccepted: 7 February 2024  \nPublished: 10 February 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Bioinorganic Chemistry, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland; [angelika.adamus@umed.lodz.pl](angelika.adamus@umed.lodz.pl)  \n2 Department of Oncobiology and Epigenetics, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland; [pawel.hikisz@biol.uni.lodz.pl](pawel.hikisz@biol.uni.lodz.pl)  \n* [Correspondence: joanna.sikora@umed.lodz.pl](Correspondence: joanna.sikora@umed.lodz.pl)  \nAbstract: The incidence of skin cancer continues to grow. There are an estimated 1.5 million new cases each year, of which nearly 350,000 are melanoma, which is often fatal. Treatment is challenging and often ineffective, with conventional chemotherapy playing a limited role in this context. These disadvantages can be overcome by the use of nanoparticles and may allow for the early detection and monitoring of neoplastic changes and determining the effectiveness of treatment. This article briefly reviews the present understanding of the characteristics of skin cancers, their epidemiology, and risk factors. It also outlines the possibilities of using nanotechnology, especially nanoparticles, for the transport of medicinal substances. Research over the previous decade on carriers of active substances indicates that drugs can be delivered more accurately to the tumor site, resulting in higher therapeutic efficacy. The article describes the application of liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles in existing therapies. It discusses the challenges encountered in nanoparticle therapy and the possibilities of improving their performance. Undoubtedly, the use of nanoparticles is a promising method that can help in the fight against skin cancer.  \nKeywords: skin cancers; drug delivery; liposomes; polymeric nanocarriers; nanoparticles; nanofibers; carbon nanotubes  \n1. Introduction  \nAt the end of 2020, the International Agency for Research on Cancer published alarming data from the global cancer burden (GLOBOCAN), which showed that in 2020 the number of newly diagnosed cancer cases increased to 19.3 million, and the total number of deaths during this period was almost 10 million [1] . The GLOBOCAN data indicated that the frequency of occurrence depended on the region and population type and that certain types of cancers are more commonly diagnosed than others. These include lung cancer, which is more prevalent among tobacco smokers, breast cancer diagnosed in both men and women, and colorectal cancers, including colon and rectal cancers, which are particularly prevalent in Western societies. In addition, prostate cancer and liver cancers, especially those related to hepatitis B and C viruses, vary considerably. The incidence of stomach cancer is also decreasing in many areas but can still constitute a significant social problem. Finally, cervical cancer is very much dependent on human papillomavirus (HPV) infection. One of the most commonly diagnosed cancers worldwide in 2020, according to GLOBOCAN, was","cbCair5hlMkH78Iw","https://ap.wps.com/l/cbCair5hlMkH78Iw","pdf",1830732,24,"English","# Abstract\n# Introduction\n# Skin Cancers","[{\"question\":\"Why are conventional treatments for skin cancer often ineffective?\",\"answer\":\"Treatment remains challenging and conventional chemotherapy plays a limited role, contributing to suboptimal outcomes.\"},{\"question\":\"How can nanoparticles improve skin cancer management?\",\"answer\":\"Nanoparticles may enable early detection and monitoring of neoplastic changes and allow more accurate drug delivery to tumor sites, increasing therapeutic efficacy.\"},{\"question\":\"Which nanomaterial types are discussed for treating skin cancer?\",\"answer\":\"The review describes applications of liposomes, carbon nanotubes, metal nanoparticles, and polymer nanoparticles, including polymeric nanocarriers and nanofibers.\"}]","Nanotechnology as a Promising Method in the Treatment of Skin Cancer | PDF",1789987443]