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Continued progress in biotechnology and precision medicine strengthens understanding and management, while improving diagnostic and therapeutic precision. Nanotechnology is emerging as a promising approach to overcome limitations of conventional diagnostics and therapies. Nanoparticles enable multimodal detection, drug delivery, targeted treatment, and improved personalization, with translational potential highlighted through analysis of preclinical studies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nanotechnology-advances-in-the-detection-and-treatment-of-lymphoid-malignancies-review/332466/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nanotechnology-advances-in-the-detection-and-treatment-of-lymphoid-malignancies-review/332466.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main purpose of this review?","Question",{"text":113,"@type":114},"It provides a comprehensive overview of current nanotechnology approaches, focusing on nanoconstructs applied to the management of lymphoid malignancies, including detection and treatment potential.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why are nanoparticles considered promising for lymphoid malignancies?",{"text":118,"@type":114},"Nanoparticles can enhance multimodal detection, enable drug delivery and targeted therapy, and support more precise, personalized approaches compared with conventional diagnostics and treatments.",{"name":120,"@type":111,"acceptedAnswer":121},"What role does measurable residual disease (MRD) play in detection?",{"text":122,"@type":114},"MRD monitoring helps assess therapeutic efficacy, predict relapse risk, and identify patients needing intensified or altered treatment regimens, requiring assays with high sensitivity and specificity.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332466,1790018213,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nNanotechnology Advances in the Detection and Treatment of Lymphoid Malignancies  \nFrancesco Maria Adamo 1, Filomena De Falco 1, Erica Dorillo 1, Daniele Sorcini 1, Arianna Stella 1, Angela Esposito 1, Roberta Arcaleni 1, Emanuela Rosati 2 and Paolo Sportoletti 1, *  \nCitation: Adamo, F.M.; De Falco, F.; Dorillo, E.; Sorcini, D.; Stella, A.; Esposito, A.; Arcaleni, R.; Rosati, E.; Sportoletti, P. Nanotechnology Advances in the Detection and Treatment of Lymphoid Malignancies. Int. J. Mol. Sci. 2024, 25, 9253. [https://](https://)[ ](https://)[doi.org/10.3390/ijms25179253](doi.org/10.3390/ijms25179253)  \nAcademic Editor: Yuri Lyubchenko  \nReceived: 17 July 2024  \nRevised: 20 August 2024  \nAccepted: 23 August 2024  \nPublished: 26 August 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Medicine and Surgery, Institute of Hematology and Center for Hemato-Oncology Research (CREO), University of Perugia, Santa Maria della Misericordia Hospital, 06132 Perugia, Italy  \n2 Department of Medicine and Surgery, Biosciences and Medical Embryology Section, University of Perugia, 06132 Perugia, Italy  \n* [Correspondence: paolo.sportoletti@unipg.it](Correspondence: paolo.sportoletti@unipg.it)  \nAbstract: Lymphoid malignancies are complex diseases with distinct biological behaviors, clinical presentations, and treatment responses. Ongoing research and advancements in biotechnology enhance the understanding and management of these malignancies, moving towards more personalized approaches for diagnosis and treatment. Nanotechnology has emerged as a promising tool to improve some limitations of conventional diagnostics as well as treatment strategies for lymphoid malignancies. Nanoparticles (NPs) offer unique advantages such as enhanced multimodal detection, drug delivery, and targeted therapy capabilities, with the potential to improve precision medicine and patient outcomes. Here, we comprehensively examine the current landscape of nanoconstructs applied in the management of lymphoid disease. Through a comprehensive analysis of preclinical studies, we highlight the translational potential of NPs in revolutionizing the field of hematological malignancies, with a specific focus on lymphoid neoplasms.  \nKeywords: lymphoid malignancies; nanoparticles; precision medicine  \n1. Introduction  \nLymphoid malignancies refer to a group of blood tumors affecting the lymphatic system and are characterized by a complex mutational landscape and a heterogeneous clinical course [1,2] . This biological complexity is mirrored by the broad spectrum of distinct diseases arising from lymphoid cells, commonly referred to as leukemias and lymphomas.  \nThe advent of precision medicine and targeted therapies has drastically improved outcomes for patients with lymphoid malignancies. The diagnosis of lymphoid neoplasms has reached high levels of sensitivity, specificity, and accuracy in recent years. However, oneof the major challenges in the detection of such neoplasms relies on the identification of low numbers of residual cells after treatments, which can be difficult to detect with traditional diagnostic tests. The availability of assays with high sensitivity and specificity is crucial for measurable residual disease (MRD) monitoring, as this allows for the assessment of therapeutic efficacy, the prediction of relapse risks and the identification of patients who may require therapeutic intensification or switch to different drug regimens [3] . Targeted agents include monoclonal antibodies, small inhibitors targeting oncogenic signaling pathways, immune checkpoint inhibitors, and chimeric antigen receptor (CAR) T-cells. Although these t","cbCaipmv1vKW1Kbx","https://ap.wps.com/l/cbCaipmv1vKW1Kbx","pdf",2358203,23,"English","# Introduction\n# Types of Nanoparticles Applied in the Biomedical Field\n## Carbon Nanoparticles","[{\"question\":\"What is the main purpose of this review?\",\"answer\":\"It provides a comprehensive overview of current nanotechnology approaches, focusing on nanoconstructs applied to the management of lymphoid malignancies, including detection and treatment potential.\"},{\"question\":\"Why are nanoparticles considered promising for lymphoid malignancies?\",\"answer\":\"Nanoparticles can enhance multimodal detection, enable drug delivery and targeted therapy, and support more precise, personalized approaches compared with conventional diagnostics and treatments.\"},{\"question\":\"What role does measurable residual disease (MRD) play in detection?\",\"answer\":\"MRD monitoring helps assess therapeutic efficacy, predict relapse risk, and identify patients needing intensified or altered treatment regimens, requiring assays with high sensitivity and specificity.\"}]","Nanotechnology Advances in the Detection and Treatment of Lymphoid Malignancies - Review | PDF",1789998325,58]