[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-378077-105":3,"doc-detail-378077-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","nanoplatforms-the-future-of-oral-cancer-treatment","Nanoplatforms: The future of oral cancer treatment","","Nanoplatforms: The future of oral cancer treatment reviews how cytotoxicity limits conventional chemotherapy for cancer care. The review focuses on nanotechnology-based drug delivery systems that encapsulate chemotherapeutic agents to enable targeted release at cancerous sites, aiming to reduce systemic toxicity. It summarizes recent clinical trial and research evidence, describing carrier types such as liposomes, polymeric nanoparticles, dendrimers, and hydrogels. It concludes that promising preclinical outcomes still require clinical evaluation of safety, efficacy, and long-term effects.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/nanoplatforms-the-future-of-oral-cancer-treatment/378077/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/nanoplatforms-the-future-of-oral-cancer-treatment/378077.png","ImageObject",300,407,{"name":42,"@type":43},"Taylor Morgan","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are cytotoxic chemotherapeutic drugs a disadvantage in oral cancer treatment?","Question",{"text":63,"@type":64},"Cytotoxicity is a key disadvantage of using chemotherapeutic drugs. Encapsulating drugs in suitable carriers is proposed to improve targeting and limit harm to healthy tissues.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What is the main goal of nanotechnology-based drug delivery systems in this review?",{"text":68,"@type":64},"The goal is targeted delivery so therapeutic agents are released preferentially at cancerous sites. This approach aims to improve drug concentration in tumors while minimizing systemic toxicity.",{"name":70,"@type":61,"acceptedAnswer":71},"Which nanoplatform formulations are discussed as carriers for oral malignancies?",{"text":72,"@type":64},"The review describes multiple nanoscale delivery systems, including liposomes, polymeric nanoparticles, dendrimers, and hydrogels, designed for controlled release and targeted delivery.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},378077,1790264243,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98},1099523885336,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",7,"DOI: 10.1002/hsr2.1471  \nNA RRATIVE REV I EW    \nNanoplatforms: The future of oral cancer treatment  \nKalpani Senevirathna1  | Shalindu M. Jayawickrama1  |  \nYovanthi A. Jayasinghe1  | Karunakalage I. P. Prabani1  | Kushani Akshala2  | Ratupaskatiye G. G. R. Pradeep1  | Hewaratne D. W. T. Damayanthi3  |  \nKalani Hettiarachchi1  | Thinley Dorji4  | Don E. Lucero‐Prisno5  |  \nRajapakse M. G. Rajapakse6  | Kehinde K. Kanmodi7,8,9,10  | Ruwan D. Jayasinghe1,7   \n1Centre for Research in Oral Cancer, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka 2Department of Agricultural Biology, Faculty of Agriculture, University of Peradeniya, Peradeniya, Sri Lanka 3Department of Nursing, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka 4Department of Internal Medicine, Central Regional Referral Hospital, Gelegphu, Bhutan  \n5Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK 6Department of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka  \n7Faculty of Dentistry, University of Puthisastra, Phnom Penh, Cambodia 8School of Dentistry, University of Rwanda, Kigali, Rwanda  \n9School of Health and Life Sciences, Teesside University, Middlesbrough, UK 10Cephas Health Research Initiative Inc, Ibadan, Nigeria  \nCorrespondence  \nKehinde K. Kanmodi, School of Health and Life Sciences, Teesside University, Middlesbrough, UK.  \nEmail: [k.kanmodi@tees.ac.uk](k.kanmodi@tees.ac.uk)  \nRuwan D. Jayasinghe, Faculty of Dentistry, University of Puthisastra, Phnom Penh, Cambodia.  \nEmail: [ruwanduminda@yahoo.com](ruwanduminda@yahoo.com)  \nAbstract  \nBackground and Aims: Cytotoxicity is a key disadvantage of using chemotherapeutic drugs to treat cancer. This can be overcome by encapsulating chemotherapeutic drugs in suitable carriers for targeted delivery, allowing them to be released only atthe cancerous sites. Herein, we aim to review the recent scientific developments in the utilization of nanotechnology‐based drug delivery systems for treating oral malignancies that can lead to further improvements in clinical practice.  \nMethods: A comprehensive literature search was conducted on PubMed, Google Scholar, ScienceDirect, and other notable databases to identify recent peer‐ reviewed clinical trials, reviews, and research articles related to nanoplatforms and their applications in oral cancer treatment.  \nResults: Nanoplatforms offer a revolutionary strategy to overcome the challenges associated with conventional oral cancer treatments, such as poor drug solubility, non‐specific targeting, and systemic toxicity. These nanoscale drug delivery systems encompass various formulations, including liposomes, polymeric nanoparticles, dendrimers, and hydrogels, which facilitate controlled release and targeted delivery of therapeutic agents to oral cancer sites. By exploiting the enhanced permeability and retention effect, Nanoplatforms accumulate preferentially in the tumor  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.  \nHealth Sci. Rep. 2023;6:e1471 . [https://doi.org/10.1002/hsr2.1471](https://doi.org/10.1002/hsr2.1471)  \n[wileyonlinelibrary.com/journal/hsr2](wileyonlinelibrary.com/journal/hsr2)  \n1 of 18  \nmicroenvironment, increasing drug concentration and minimizing damage to healthy tissues. Additionally, nanoplatforms can be engineered to carry multiple drugs or a combination of drugs and diagnostic agents, enabling personalized and precise treatment approaches.  \nConclusion: The utilization of nanoplatforms in oral cancer treatment holds significant promise in revolutionizing therapeutic strategies. Despite the promising results in preclinical studies, further research is required to evaluat","cbCaicrl1KhEmmt2","https://ap.wps.com/l/cbCaicrl1KhEmmt2","pdf",3942573,18,"English","# Abstract\n## Background and Aims\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Oral squamous cell carcinoma overview\n## Epidemiology and risk factors\n# Methods\n## Literature search strategy","[{\"question\":\"Why are cytotoxic chemotherapeutic drugs a disadvantage in oral cancer treatment?\",\"answer\":\"Cytotoxicity is a key disadvantage of using chemotherapeutic drugs. Encapsulating drugs in suitable carriers is proposed to improve targeting and limit harm to healthy tissues.\"},{\"question\":\"What is the main goal of nanotechnology-based drug delivery systems in this review?\",\"answer\":\"The goal is targeted delivery so therapeutic agents are released preferentially at cancerous sites. This approach aims to improve drug concentration in tumors while minimizing systemic toxicity.\"},{\"question\":\"Which nanoplatform formulations are discussed as carriers for oral malignancies?\",\"answer\":\"The review describes multiple nanoscale delivery systems, including liposomes, polymeric nanoparticles, dendrimers, and hydrogels, designed for controlled release and targeted delivery.\"}]","Nanoplatforms: The future of oral cancer treatment | PDF",1790228306,45,{"code":4,"msg":82,"data":100},[101,105,109,113,118,123,126,131,136,139,143],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":115,"show_sort_weight":116,"slug":117},5,"Comic",60,"comic",{"id":119,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":121,"slug":122},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":124,"slug":125},40,"healthcare",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":129,"slug":130},8,"Research & Report",30,"research-report",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":133,"show_sort_weight":134,"slug":135},9,"Religion & Spirituality",20,"religion-spirituality",{"id":134,"doc_module":4,"doc_module_name":25,"category_name":137,"show_sort_weight":134,"slug":138},"World Cup","world-cup",{"id":140,"doc_module":4,"doc_module_name":25,"category_name":141,"show_sort_weight":140,"slug":142},10,"Lifestyle","lifestyle",{"id":144,"doc_module":4,"doc_module_name":25,"category_name":145,"show_sort_weight":114,"slug":146},19,"General","general"]