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Breast cancer, a leading cause of morbidity and mortality in women, drives efforts to create highly potent nanotherapies that can improve diagnostic accuracy, enable targeted drug delivery, and reduce progression, relapse, and invasive metastasis. This review summarizes novel nanotheranostic approaches for diagnosing, treating, and preventing breast cancer, emphasizing smart nanocarriers, ligands and tracking probes, and nano-systems designed to minimize toxicity. It discusses different diagnosis, treatment, and prevention strategies using metal and metal oxide nanoparticles.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nanoparticle-mediated-diagnosis-treatment-and-prevention-of-breast-cancer-review-and-background-overview/330993/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nanoparticle-mediated-diagnosis-treatment-and-prevention-of-breast-cancer-review-and-background-overview/330993.png","ImageObject",300,407,{"name":92,"@type":93},"Noah","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are nanoparticles considered important for breast cancer management?","Question",{"text":112,"@type":113},"Nanoparticles offer responsive platforms for breast cancer by improving diagnostic accuracy, supporting targeted therapies, and helping limit disease progression. Their advanced physicochemical properties enable smart drug delivery and tracking approaches.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What nanotheranostic approaches does the review emphasize?",{"text":117,"@type":113},"The review focuses on methods for diagnosis, treatment, and prevention using metal and metal oxide nanoparticles. It highlights smart nanocarriers that encapsulate drugs, ligands, and tracking probes.",{"name":119,"@type":110,"acceptedAnswer":120},"Which modern diagnostic methods are mentioned for preliminary breast cancer detection?",{"text":121,"@type":113},"The document lists self-diagnosis, medical check-ups, radiography, positron emission tomography (PET), mammography, and magnetic resonance imaging (MRI).","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330993,1790245064,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095462418,"https://ap-avatar.wpscdn.com/avatar/80000253c1241d02b47?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778826106357471780","Nanoscale Advances  \nREVIEW  \nCite this: Nanoscale Adv., 2024, 6, 3699  \nReceived 4th November 2023 Accepted 16th May 2024  \nDOI: 10.1039/d3na00965c[rsc.li/nanoscale-advances](rsc.li/nanoscale-advances)  \nNanoparticle-mediated diagnosis, treatment, and prevention of breast cancer  \nLipsa Leena Panigrahi,  a Pallavi Samal,a Sameer Ranjan Sahoo,a Banishree Sahoo,a Arun Kumar Pradhan,a Sailendra Mahanta, b Sandip Kumar Rathcand Manoranjan Arakha  *a  \nBy virtue of their advanced physicochemical properties, nanoparticles have attracted significant attention from researchers for application in diverse fields of medical science. Breast cancer, presenting a high risk of morbidity and mortality, frequently occurs in women and is considered a malignant tumor. Globally, breast cancer is considered the second leading cause of death. Accordingly, its poor prognosis, invasive metastasis, and relapse have motivated oncologists and nano-medical researchers to develop highly potent nanotherapies to cure this deadly disease. In this case, nanoparticles have emerged as responsive platforms for breast cancer management, providing new approaches to improve the diagnostic accuracy, deliver targeted therapies, and limit the progression of this disease. Recently, smart nanocarriers encapsulating drugs, ligands, and tracking probes have been developed for the specific therapy of breast cancers. Further, efforts have been devoted to developing various nano-systems with minimal toxicity. The aim of this review is to present a background on novel nanotheranostic methods that can be employed to diagnose and treat breast cancers and encourage readers to focus on the development of novel nanomedicine for breast cancers and other deadly diseases. In this context, we discuss different methods for the diagnosis, treatment, and prevention of breast cancers using different metal and metal oxide nanoparticles.  \n1. Introduction  \nBreast cancer has rapidly emerged as a crucial health issue faced by women in the past seven decades.1 Different specialties including surgery, gynecology, pathology, radiology, hematology, oncology, nuclear medicine, and radiation oncology are engaged in breast cancer therapies. Regarding new cases, about 268 000 new cancer afflictions were diagnosed according toa report by the American Cancer Research Society, which also noted an increasing rate of 1.5% in incidences.1 The global statistics according to a 2020 report illustrated that breast cancer is quite alarming, totaling an estimated 19 million new cases and 10 million deaths annually.2 Nearly 11 million breast cancer deaths are expected by 2030 . Developed countries such as Australia, New Zealand, Western and Northern Europe, and North America are at a higher risk (55 cases per 100 000 individuals) of developing breast cancer compared to developing countries such as Central America, Eastern and Middle Africa, and South-Central Asia (29.7 cases per 100 000 individuals) .  \naCenter For Biotechnology, Siksha O Anusandhan University, Bhubaneswar, Odisha,  \n751003, [India. E-mail: marakha@soa.ac.in](India. E-mail: marakha@soa.ac.in); [manoranjan.arakha@gmail.com](manoranjan.arakha@gmail.com)  \n[b](bSchool of Pharmacy)[School of Pharmacy](bSchool of Pharmacy), [The Assam Kaziranga University](The Assam Kaziranga University), [Koraikhowa](Koraikhowa), [NH-37](NH-37), [Jorhat](Jorhat),  \nAssam, 785 006, India  \ncDepartment of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA  \nFurthermore, developed countries have shown 17% higher mortality rates than developing countries.2 However, in recent years, a noticeable surge in breast cancer incidences has been reported in developing countries (Fig. 1) . Widely proclaimed asthe most prevalent ailment in women, breast cancer is widely diagnosed in adolescent and middle-aged women. Age represents the prime risk factor for breast cancer, followed by an overdose of estrogen, early menarche, high intake ","cbCaihS6FlCi62rv","https://ap.wps.com/l/cbCaihS6FlCi62rv","pdf",485653,15,"English","# Introduction\n## Global burden and risk factors\n## Current therapies and clinical management\n## Modern diagnostic approaches\n# Nanoparticle-mediated nanotheranostic strategies","[{\"question\":\"Why are nanoparticles considered important for breast cancer management?\",\"answer\":\"Nanoparticles offer responsive platforms for breast cancer by improving diagnostic accuracy, supporting targeted therapies, and helping limit disease progression. Their advanced physicochemical properties enable smart drug delivery and tracking approaches.\"},{\"question\":\"What nanotheranostic approaches does the review emphasize?\",\"answer\":\"The review focuses on methods for diagnosis, treatment, and prevention using metal and metal oxide nanoparticles. It highlights smart nanocarriers that encapsulate drugs, ligands, and tracking probes.\"},{\"question\":\"Which modern diagnostic methods are mentioned for preliminary breast cancer detection?\",\"answer\":\"The document lists self-diagnosis, medical check-ups, radiography, positron emission tomography (PET), mammography, and magnetic resonance imaging (MRI).\"}]","Nanoparticle-mediated diagnosis, treatment, and prevention of breast cancer - Review and background overview | PDF",1789991019,38]