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Controlled trials, meta-analyses, and Cochrane review articles were screened under criteria requiring skin-cancer-focused nanoparticle utility, outcome metrics, population detail, English full text, and archived journal availability. Forty-three studies met inclusion criteria, and qualitative synthesis highlights enhanced bioavailability, reduced toxicity, improved permeability and retention, and inhibition of tumor growth and 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Cancer: A Systematic Review  \nMichael Joseph Diaz 1,*, Nicole Natarelli 2, Shaliz Aflatooni 2, Sarah J. Aleman 3, Sphurti Neelam 1, Jasmine Thuy Tran 4, Kamil Taneja 5, Brandon Lucke-Wold 6 and Mahtab Forouzandeh 7  \nCitation: Diaz, M.J.; Natarelli, N.; Aflatooni, S.; Aleman, S.J.; Neelam, S.; Tran, J.T.; Taneja, K.; Lucke-Wold, B.; Forouzandeh, M. Nanoparticle-Based Treatment Approaches for Skin Cancer: A Systematic Review. Curr.  \nOncol. 2023, 30, 7112–7131. [https://](https://)[ ](https://)[doi.org/10.3390/curroncol30080516](doi.org/10.3390/curroncol30080516)  \nReceived: 13 June 2023  \nRevised: 1 July 2023  \nAccepted: 17 July 2023  \nPublished: 25 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 College of Medicine, University of Florida, Gainesville, FL 32610, USA  \n2 Morsani College of Medicine, University of South Florida, Tampa, FL 33602, USA  \n3 School of Medicine, Louisiana State University, New Orleans, LA 70112, USA  \n4 School of Medicine, Indiana University, Indianapolis, IN 46202, USA  \n5 Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA  \n6 Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA  \n7 Department of Dermatology, University of Florida, Gainesville, FL 32606, USA  \n* Correspondence: michaeldiaz@ufl.edu  \nAbstract: Nanoparticles have shown marked promise as both antineoplastic agents and drug carriers. Despite strides made in immunomodulation, low success rates and toxicity remain limitations within the clinical oncology setting. In the present review, we assess advances in drug delivery nanoparticles, for systemic and topical use, in skin cancer treatment. A systematic review of controlled trials, metaanalyses, and Cochrane review articles was conducted. Eligibility criteria included: (1) a primary focus on nanoparticle utility for skin cancer; (2) available metrics on prevention and treatment outcomes; (3) detailed subject population; (4) English language; (5) archived as full-text journal articles. A total of 43 articles were selected for review. Qualitative analysis revealed that nanoscale systems demonstrate significant antineoplastic and anti-metastasis properties: increased drug bioavailability, reduced toxicity, enhanced permeability and retention effect, as well as tumor growth inhibition, among others. Nanoformulations for skin cancers have largely lagged behind those tested in other cancers–several of which have commercialized formulae. However, emerging evidence has indicateda powerful role for these carriers in targeting primary and metastatic skin cancers.  \nKeywords: nanoparticle; skin cancer; drug carriers; systematic review; organic; inorganic  \n1. Introduction  \nThe American Cancer Society estimates that north of 95 thousand new melanomas will be diagnosed in 2023, with an expected death toll of nearly 8 thousand [1] . Risk factors for skin cancer development include positive family history, sun and ultraviolet radiation exposure, genodermatoses, and light complexion, among others. Beyond complications and outcomes, skin cancer also imposes significant financial strains: the annual cost of treating skin cancer has been estimated at over USD 8 billion since 2007, compared to total treatment costs of USD 3 .6 billion from 2002 to 2006 [2,3] . Per-case treatment costs for basal cell carcinoma and squamous cell carcinomas diagnosed in 2011, secondary to occupational solar radiation exposure, were greater than CAD 5.5 thousand and 10.5 thousand, respectively [4] . Worse yet, accumulating evidence indicates that primary melanoma survivors are at an elevated","cbCaioh0dHlRgbce","https://ap.wps.com/l/cbCaioh0dHlRgbce","pdf",1446742,"English","# Abstract\n# Introduction\n## Epidemiology and burden of skin cancer\n## Challenges in therapy for locally advanced and metastatic disease\n## Rationale for nanoparticle drug delivery\n## Classification of nanoparticle types","[{\"question\":\"What is the goal of this systematic review on skin cancer treatment?\",\"answer\":\"It assesses advances in nanoparticle-based drug delivery for systemic and topical treatment of skin cancer, focusing on prevention and treatment outcomes.\"},{\"question\":\"How were studies selected for inclusion?\",\"answer\":\"Selection required a primary focus on nanoparticle utility for skin cancer, available prevention/treatment outcome metrics, detailed subject populations, English full-text journal articles, and archived full-text availability.\"},{\"question\":\"What benefits did the review attribute to nanoscale systems?\",\"answer\":\"Nanoscale systems were linked to increased drug bioavailability, reduced toxicity, enhanced permeability and retention, and tumor growth inhibition, including anti-metastasis properties.\"}]","Nanoparticle-Based Treatment Approaches for Skin Cancer - A Systematic Review | PDF",1790228656]