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PubMed, Embase, Scopus, Web of Science, and Google Scholar were searched for NP applications, with data extraction and quality assessment across included studies. From 147 records, 17 articles were included, showing enhanced sensitivity and specificity for saliva analysis using gold NP enzyme-linked immunosorbent assays and supporting early identification. Novel NP-based immunosensor therapies suggest targeted drug delivery, chemo-photothermal combinations, gene silencing, and differentiation of malignant versus healthy states using methods such as SERS and optical coherence tomography.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nanoparticle-based-immunosensors-for-enhanced-dna-analysis-in-oral-cancer-a-systematic-review/328552/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nanoparticle-based-immunosensors-for-enhanced-dna-analysis-in-oral-cancer-a-systematic-review/328552.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the purpose of this systematic review?","Question",{"text":112,"@type":113},"To evaluate the diagnostic and therapeutic potential of nanoparticle-based immunosensors for oral cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which databases were searched for eligible nanoparticle applications?",{"text":117,"@type":113},"PubMed, Embase, Scopus, Web of Science, and Google Scholar were searched for NP applications in oral cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"What kinds of diagnostic and therapeutic improvements were reported?",{"text":121,"@type":113},"Many studies reported improved sensitivity and specificity for saliva-based assays using gold NP ELISA, along with therapeutic approaches such as targeted drug delivery, chemo-photothermal therapy, and gene silencing.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328552,1789996897,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","| Review Article |  |\n| --- | --- |\n|  |  |\n| Nanoparticle‑based immunosensors for enhanced DNA analysis in oral cancer: A systematic review\u003Cbr>Neha Gupta1, Ankur Bhargava2, Sonal Saigal1, Vini Mehta3\u003Cbr>1 Department of Oral Pathology, Microbiology and Forensic Odontology, Dental College, Rajendra Institute of Medical Sciences (RIMS), Ranchi, 2 Department of Oral Pathology and Microbiology, Hazaribag College of Dental Sciences and Hospital, Hazaribag, Jharkhand, 3 Department of Dental Research Cell, Dr. D. Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India |  |\n|  |  |\n| Abstract \u003Cbr>To investigate the diagnostic and therapeutic potential of nanoparticle (NP)‑based immunosensors in the field of oral cancer. PubMed, Embase, Scopus, Web of Science, and Google Scholar databases were explored for NP applications in oral cancer. Data extraction in terms and quality assessment of all the articles were done. Out of 147, 17 articles were included in this review. A majority of the studies showed improved sensitivity and specificity for saliva analysis using an enzyme‑linked immunosorbent assay based on gold NPs, improving early identification . Additionally, novel therapeutic approaches, utilising NP‑based immunosensors, demonstrated targeted drug delivery, coupled chemo‑photothermal therapy, and gene silencing. Imaging methods have made it possible to distinguish between malignant and healthy states, such as surface‑enhanced Raman scattering and optical coherence tomography. The reviews’ findings highlight the transformational potential of NP‑based immunosensors in addressing the difficulties associated with diagnosing and treating oral cancer. However, for an accurate interpretation and application of NP‑based solutions in clinical practise, it is essential to be thoroughly aware of the intricacies involved, and the synthesised data in this review support the continued investigation and improvement of NP‑based therapies in the ongoing effort to improve the management of oral cancer.\u003Cbr>Keywords: DNA analysis, immunosensors, nanoparticles, oral cancer, systematic review |  |\n| Address for correspondence: Dr. Vini Mehta, Department of Dental Research Cell, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune ‑ 411018, India.\u003Cbr>E‑mail: vini. mehta@statsense. in\u003Cbr>Submitted: 08‑Aug‑2023, Revised: 10‑Dec‑2023, Accepted: 20‑Dec‑2023, Published: 11‑Jul‑2024 |  |\n\nINTRODUCTION  \nOral cancer has a disconcerting 5‑year survival rate of about 50%, making it the sixth most common malignancy worldwide. [1] A number of incapacitating symptoms, including dysphagia, altered facial look, chronic pain, and psychological distress, are brought on by cancer’s aggressive nature, which is characterised by rapid dispersion, invasive  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code: | Website:\u003Cbr>[https://journals.lww.com/JPAT/](https://journals.lww.com/JPAT/) |\n| |  |\n|  | DOI:\u003Cbr>10.4103/jomfp.jomfp_345_23 |\n\ntendencies, and a propensity for metastasis. [2] Its aetiology is based on genetic variations that affect cell cycles, which are exacerbated by excessive alcohol and tobacco use.[3,4] Diagnostic difficulties frequently lead to postponed treatments, which are worsened by difficult therapeutic modalities such surgery, radiotherapy, and chemotherapy, each of which has constricting adverse effects.[4] Optimising  \nThis is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.  \nFor [reprints contact:](reprints contact: WKHLRPMedknow_reprints@wolterskluwer.com)[ WKHLRPMedknow_reprints@wolterskluwer.com](reprints contact: WKHLRPMedknow_reprints@wolterskluwer.com)  \nHow to cite this article:","cbCaiqh6tu3zwv9H","https://ap.wps.com/l/cbCaiqh6tu3zwv9H","pdf",1831314,"English","# Abstract\n# Introduction","[{\"question\":\"What is the purpose of this systematic review?\",\"answer\":\"To evaluate the diagnostic and therapeutic potential of nanoparticle-based immunosensors for oral cancer.\"},{\"question\":\"Which databases were searched for eligible nanoparticle applications?\",\"answer\":\"PubMed, Embase, Scopus, Web of Science, and Google Scholar were searched for NP applications in oral cancer.\"},{\"question\":\"What kinds of diagnostic and therapeutic improvements were reported?\",\"answer\":\"Many studies reported improved sensitivity and specificity for saliva-based assays using gold NP ELISA, along with therapeutic approaches such as targeted drug delivery, chemo-photothermal therapy, and gene silencing.\"}]","Nanoparticle-based immunosensors for enhanced DNA analysis in oral cancer: A systematic review | PDF",1789980164,23]