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Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, offers a strategy to counter drug resistance in lung cancer. Recent nanotechnology advances support targeted delivery and precise control of ferroptosis pathways, enabling improved therapeutic performance. This review compiles strategies for using nanomedicine to trigger ferroptosis in lung cancer, highlighting molecular targets including GPX4, System Xc−, and FSP1, and delivery platforms such as metal nanoparticles, nanozymes, and responsive liposomes.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nanomedicine-initiates-ferroptosis-for-enhanced-lung-cancer-therapy/367656/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nanomedicine-initiates-ferroptosis-for-enhanced-lung-cancer-therapy/367656.png","ImageObject",300,407,{"name":92,"@type":93},"Terk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is ferroptosis considered promising for lung cancer therapy?","Question",{"text":113,"@type":114},"Ferroptosis is iron-dependent and driven by lipid peroxidation. It may help overcome drug resistance that limits conventional therapies.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which molecular targets are emphasized for inducing ferroptosis?",{"text":118,"@type":114},"The review focuses on key targets including GPX4, System Xc−, and FSP1.",{"name":120,"@type":111,"acceptedAnswer":121},"What nanomedicine delivery platforms are discussed in the review?",{"text":122,"@type":114},"It summarizes innovative platforms such as metal nanoparticles, nanozymes, and responsive liposomes for ferroptosis induction.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},367656,1790470081,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Drug Delivery  \n2025, vOl. 32, NO. 1, 2527752  \n[https://doi.org/10.1080/10717544.2025.2527752](https://doi.org/10.1080/10717544.2025.2527752)  \nReview ARticle    \nNanomedicine initiates ferroptosis for enhanced lung cancer therapy  \nYitianhe Xua\\#, Kaiying Zhanga\\#, Zhanzheng Yea, Zihao Huanga, Ruijie chena, Youting Zhanga, Hailin Zhanga,b and longfa Koua  \naWenzhou Municipal Key laboratory of Pediatric Pharmacy, Department of Pharmacy, The Second Affiliated Hospital and yuying Children’s Hospital of Wenzhou Medical university, Wenzhou, China; bDepartment of Children’s respiration Disease, The Second Affiliated Hospital andyuying Children’s Hospital of Wenzhou Medical university, Wenzhou, China  \nABSTRACT  \nlung cancer is the second most common cancer worldwide, with persistently high morbidity and mortality rates. Despite years of research in the field, a complete cure for this disease remains elusive. current clinical treatment options primarily include chemotherapy, surgery, and targeted drugs. However, these treatments are often limited by the highly metastatic nature of lung tumors and the development of drug resistance, resulting in suboptimal therapeutic outcomes. Ferroptosis is an iron-dependent cell death mechanism driven by lipid peroxidation, offers promising potential to overcome drug resistance in lung cancer. Recent advances in nanotechnology have enabled targeted delivery and precise regulation of ferroptosis pathways, addressing the limitations of conventional therapies. this review systematically summarizes current strategies utilizing nanomedicine to induce ferroptosis in lung cancer, with a focus on key molecular targets, such as GPX4, System Xc −, and FSP1, as well as innovative delivery platforms including metal nanoparticles, nanozymes, and responsive liposomes. Unique challenges in pulmonary drug delivery, such as mucociliary clearance and oxidative microenvironments are also discussed, along with lung cancer-specific solutions like inhalable systems and tumor microenvironment remodeling. Furthermore, we compare ferroptosis nanotherapies across different cancers to highlight the distinctive innovations in lung cancer. this article provides a comprehensive overview of recent progress and proposes optimized strategies to enhance therapeutic efficacy, offering insights into the translational potential of ferroptosis-based nanomedicine in lung cancer treatment.  \nARTICLE HISTORY  \nReceived 12 April 2025 Accepted 26 June 2025  \nKEYWORDS  \nlung cancer; ferroptosis; programmed cell death; nanomedicine; combined therapy  \n1. Introduction  \nlung cancer is one of the most common and deadliest malignant tumors worldwide, with an estimated 2.2 million people diagnosed annually and 1.79 million deaths caused by the disease (thai et al. 2021) . lung cancer is mainly divided into two types: non-small cell lung cancer (NSclc) and small cell lung cancer (Sclc) (Hirsch et al. 2017; thai et al. 2021) . NSclc accounts for about 85% of lung cancer cases, with common subtypes including adenocarcinoma, squamous cell carcinoma, and large cell carcinoma (Oser et al. 2015; Kong et al. 2023) . Although Sclc has a lower incidence, it is highly aggressive and progresses rapidly. Major risk factors for lung cancer include long-term smoking, exposure to harmful chemicals (such as asbestos and radon), air pollution, and genetic predisposition. Smoking is considered the primary cause, responsible for the vast majority of cases, especially for Sclc (Oliver 2022) . early symptoms of lung cancer are often subtle, including coughing, blood-tinged sputum, chest  \npain, and shortness of breath. when the tumor spreads to distant organs, patients may experience general fatigue and weight loss. Due to the lack of obvious early symptoms, many patients are diagnosed at an advanced stage, making treatment more difficult (Hirsch et al. 2017) . treatment options for lung cancer include surgery, radiotherapy, chemotherapy, targeted therapy, and immun","cbCaimgoIW8PVYUx","https://ap.wps.com/l/cbCaimgoIW8PVYUx","pdf",16507626,26,"English","# Introduction\n## Background on lung cancer and treatment challenges\n## Programmed cell death and ferroptosis overview","[{\"question\":\"Why is ferroptosis considered promising for lung cancer therapy?\",\"answer\":\"Ferroptosis is iron-dependent and driven by lipid peroxidation. It may help overcome drug resistance that limits conventional therapies.\"},{\"question\":\"Which molecular targets are emphasized for inducing ferroptosis?\",\"answer\":\"The review focuses on key targets including GPX4, System Xc−, and FSP1.\"},{\"question\":\"What nanomedicine delivery platforms are discussed in the review?\",\"answer\":\"It summarizes innovative platforms such as metal nanoparticles, nanozymes, and responsive liposomes for ferroptosis induction.\"}]","Nanomedicine initiates ferroptosis for enhanced lung cancer therapy | PDF",1790171807,66]