[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-374936-105":59,"doc-detail-374936-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","nanomedicine-for-cancer-and-autoimmune-immunotherapy","Nanomedicine for Cancer and Autoimmune Immunotherapy","","Nanomedicine is a transformative platform that improves the precision and efficacy of cancer immunotherapy and autoimmune immunotherapy, enabling advanced customization. Nanoscale platforms allow researchers to modulate immune responses across spatial and temporal scales to address limits of conventional approaches, including immune evasion, systemic toxicity, and poor pharmacokinetics. Stimuli-sensitive nanoparticles, exosome-mimetic vesicle systems, and CRISPR-enabled particles can deliver targeted immunomodulators, antigens, and gene-editing tools to specific immune compartments. These innovations support immune cell reprogramming, tolerance rejuvenation, and antitumor immunity expansion while reducing off-target effects. Integration with artificial intelligence and multiomics supports personalized nano-immunotherapies based on patient immuno-signatures, with translational opportunities for precision immune modulation in oncology and autoimmune diseases.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nanomedicine-for-cancer-and-autoimmune-immunotherapy/374936/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nanomedicine-for-cancer-and-autoimmune-immunotherapy/374936.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does nanomedicine improve immunotherapy for cancer and autoimmune diseases?","Question",{"text":113,"@type":114},"Nanomedicine enhances precision and efficacy by enabling nanoscale control of immune responses across spatial and temporal scales, helping overcome issues such as immune evasion, systemic toxicity, and poor pharmacokinetics.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What types of nanoparticles are highlighted as enabling targeted immune modulation?",{"text":118,"@type":114},"The text describes stimuli-sensitive nanoparticles, exosome-mimetic vesicle nanoparticles, and CRISPR-based nanoparticles that can deliver immunomodulators, antigens, and gene-editing systems to particular immune compartments.",{"name":120,"@type":111,"acceptedAnswer":121},"What therapeutic outcomes are associated with these nano-immunotherapy strategies?",{"text":122,"@type":114},"The innovations are linked to immune cell reprogramming, immune tolerance rejuvenation, and expansion of antitumor immunity, aiming to limit significant off-target effects.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},374936,1790271068,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":26},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review  \nNanomedicine for Cancer and Autoimmune Immunotherapy  \nAshi Ramavat 1, Priya Antil 2, Soniya Kaushik 1, Baby Kataria 3 and Ramendra Pati Pandey 1, *  \nAcademic Editor: Simone Anfossi  \nReceived: 9 November 2025  \nRevised: 4 December 2025  \nAccepted: 9 December 2025  \nPublished: 11 December 2025  \nCitation: Ramavat, A.; Antil, P.; Kaushik, S.; Kataria, B.; Pandey, R.P. Nanomedicine for Cancer and Autoimmune Immunotherapy. Int. J. Mol. Sci. 2025, 26, 11941. [https://](https://)[ ](https://)[doi.org/10.3390/ijms262411941](doi.org/10.3390/ijms262411941)  \n[Copyright:](Copyright:) © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Biotechnology, SRM University, Delhi-NCR, Sonepat 131029, Haryana, India; [ashi8472@yahoo.com](ashi8472@yahoo.com) (A.R.)  \n2 Department of Biotechnology, Deenbandhu Chhotu Ram University of Science and Technology (DCRUST), Sonepat 131001, Haryana, India  \n3 Department of Microbiology, SRM University, Delhi-NCR, Sonepat 131029, Haryana, India  \n* Correspondence: [ramendra.pandey@gmail.com](ramendra.pandey@gmail.com)  \nAbstract  \nNanomedicine has now become a transformative platform that enhances the precision and efficacy of immunotherapy approaches and allows customizations like never before when it comes to cancer, as well as autoimmune conditions. Using platforms based on nanoscale, researchers have been able to manipulate immune responses operating across spatial and temporal scales to address key limitations of conventional immunotherapy associated with working with immune response such as immune evasion, systemic toxicity, and poor pharmacokinetics. Sophisticated nanoparticles (such as stimuli-sensitive ones, exosome-mimetic vesicle nanoparticles, and nanoparticles with CRISPR) allow directed immunomodulators, antigens, and gene-editing systems to reach one or more particular immune compartments. The innovations allow reprogramming of immune cells, immune tolerance rejuvenation, and expansion of antitumor immunity without significant off-target effects. Finding applications in integrating the artificial intelligence as well as multiomics techniques, the process leads to personalization of the nano-immunotherapies based on patient-specific immuno-signatures. The chapter discusses the mechanistic rationale, therapeutic advancement, and the translational opportunities of nanotechnology-based immunotherapies that define them as part of a foundation of future generations of clinical approaches to precision immune modulation in oncology and autoimmune diseases.  \nKeywords: tumor microenvironment (TME); CAR-T cell enhancement; cytokine regulation; exosome-mimetic nanoplatforms  \n1. Introduction  \nWith the introduction of nanotechnology into the medical field, nanomedicine asa combination of these two disciplines has become a ground-breaking approach in the treatment of cancer and immunology with new solutions offered in the field diagnosis, targeted therapy, and prevention of the disease. Nanomedicine can take special advantage of exploiting nanomaterials (scale 1–100 nm), providing strengths such as enhanced penetration to tissues and therapeutic agents, controlled drug delivery, and personalized immune response interactions. Such properties are especially advantageous in the field of immunotherapy, where a fine balance between control over the immune response and favorable versus adverse effects is important to therapeutic efficacy, having the benefits of high specificity [1] . Along with a growing understanding of immune derangement in cancer and autoimmune diseases, the role of nanomedicine in immunotherapy has grown. The two types of diseases, although being different in their clinical presentation, are b","cbCaip0u5SaImT0I","https://ap.wps.com/l/cbCaip0u5SaImT0I","pdf",1164185,24,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"How does nanomedicine improve immunotherapy for cancer and autoimmune diseases?\",\"answer\":\"Nanomedicine enhances precision and efficacy by enabling nanoscale control of immune responses across spatial and temporal scales, helping overcome issues such as immune evasion, systemic toxicity, and poor pharmacokinetics.\"},{\"question\":\"What types of nanoparticles are highlighted as enabling targeted immune modulation?\",\"answer\":\"The text describes stimuli-sensitive nanoparticles, exosome-mimetic vesicle nanoparticles, and CRISPR-based nanoparticles that can deliver immunomodulators, antigens, and gene-editing systems to particular immune compartments.\"},{\"question\":\"What therapeutic outcomes are associated with these nano-immunotherapy strategies?\",\"answer\":\"The innovations are linked to immune cell reprogramming, immune tolerance rejuvenation, and expansion of antitumor immunity, aiming to limit significant off-target effects.\"}]","Nanomedicine for Cancer and Autoimmune Immunotherapy | PDF",1790202801]