[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-382015-105":59,"doc-detail-382015-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","nanoceria-an-innovative-strategy-for-cancer-treatment","Nanoceria: an innovative strategy for cancer treatment","","Nanoceria, cerium oxide nanoparticles containing co-existing Ce3+ and Ce4+, provide self-regenerative, redox-responsive dual-catalytic actions for cancer therapy. Surface features and the local environment determine anti-oxidative or pro-oxidative effects that tune reactive oxygen species (ROS). By mimicking ROS-related enzymes, nanoceria protects normal cells at physiological pH while increasing ROS in the acidic tumour microenvironment to drive cancer cell death. It also generates oxygen to alleviate tumour hypoxia and enhance PDT, PTT, RT, targeted and chemotherapies, and can be engineered as nanocarriers for improved delivery or combination synergy. Despite strong preclinical results, knowledge gaps remain due to limited studies using physiologically relevant disease models; this review covers dual catalysis in response to pH and oxygen gradients, recent nanoceria platforms for direct and indirect anti-cancer effects, and challenges in clinical translation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nanoceria-an-innovative-strategy-for-cancer-treatment/382015/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nanoceria-an-innovative-strategy-for-cancer-treatment/382015.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes nanoceria suitable for cancer treatment?","Question",{"text":112,"@type":113},"Nanoceria is cerium oxide nanoparticles with co-existing Ce3+ and Ce4+, enabling self-regenerative, redox-responsive dual-catalytic activity that modulates ROS for therapy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does nanoceria affect normal cells versus tumour cells?",{"text":117,"@type":113},"At physiological pH, nanoceria mimics ROS-related enzymes to protect normal cells from oxidative stress, while in the slightly acidic tumour microenvironment it promotes ROS production to trigger cancer cell death.",{"name":119,"@type":110,"acceptedAnswer":120},"Why does alleviating tumour hypoxia matter for therapy outcomes?",{"text":121,"@type":113},"Nanoceria can generate molecular oxygen, relieving tumour hypoxia and sensitising tumour cells, improving outcomes across PDT, PTT, radiation, targeted and chemotherapies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382015,1790545177,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Cellular and Molecular Life Sciences (2023) 80:46  \n[https://doi.org/10.1007/s00018-023-04694-y](https://doi.org/10.1007/s00018-023-04694-y) Cellular and Molecular Life Sciences  \nNanoceria: an innovative strategy for cancer treatment  \nJoyce L. Y. Tang1,2 · Shehzahdi S. Moonshi1 · Hang T. Ta1,2,3  \nReceived: 17 June 2022 / Revised: 19 December 2022 / Accepted: 9 January 2023 / Published online: 19 January 2023 © The Author(s) 2023, corrected publication 2023  \nAbstract  \nNanoceria or cerium oxide nanoparticles characterised by the co-existing of Ce3+ and Ce4+ that allows self-regenerative, redox-responsive dual-catalytic activities, have attracted interest as an innovative approach to treating cancer. Depending on surface characteristics and immediate environment, nanoceria exerts either anti-or pro-oxidative effects which regulate reactive oxygen species (ROS) levels in biological systems. Nanoceria mimics ROS-related enzymes that protect normal cells at physiological pH from oxidative stress and induce ROS production in the slightly acidic tumour microenvironment to trigger cancer cell death. Nanoceria as nanozymes also generates molecular oxygen that relieves tumour hypoxia, leading to tumour cell sensitisation to improve therapeutic outcomes of photodynamic (PDT), photothermal (PTT) and radiation (RT), targeted and chemotherapies. Nanoceria has been engineered as a nanocarrier to improve drug delivery or in combination with other drugs to produce synergistic anti-cancer effects. Despite reported preclinical successes, there are still knowledge gaps arising from the inadequate number of studies reporting findings based on physiologically relevant disease models that accurately represent the complexities of cancer. This review discusses the dual-catalytic activities of nanoceria responding to pH and oxygen tension gradient in tumour microenvironment, highlights the recent nanoceria-based platforms reported to be feasible direct and indirect anti-cancer agents with protective effects on healthy tissues, and finally addresses the challenges in clinical translation of nanoceria based therapeutics.  \nKeywords Nanomedicine · Cerium oxide · Redox-responsive nanozymes · Oxidative stress · Tumour hypoxia · Treatment development  \nIntroduction  \nCancer is the general term utilised to demonstrate a heterogenous group of diverse diseases characterised by rapid, uncontrolled growth of abnormal cells that can affect any part of the body. Cancer can metastasize and spread to other organs if not detected at an early stage, making it a difficult disease to treat, resulting in a leading cause of death globally [1] . The World Health Organisation’s International Agency for Research (WHO IARC) [https://gco.iarc.fr/today/](https://gco.iarc.fr/today/)  \n* Hang T. Ta[h.ta@griffith.edu.au](h.ta@griffith.edu.au)  \n1 Queensland Micro-and Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia  \n2 Bioscience Discipline Department, School of Environment and Science, Griffith University, Nathan Campus, Brisbane, QLD 4111, Australia  \n3 Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, QLD 4072, Australia  \nonline-analysis-pie estimated 19.3 million cancer diagnosis with more than 50% mortality (9.96 million) in 2020. Despite advancements in cancer treatment strategies, cancers including lung, colorectal, prostate and stomach cancers still demonstrate poor five-year survival rate [2] especially with the COVID-19 global pandemic delaying diagnosis and disrupting access to cancer care and treatment options [3, 4] . Factors contributing to poor prognosis and cancer relapses including metastasis, intrinsic and acquired resistance to chemotherapeutic drugs revealed the ongoing need to enhance conventional therapies such as chemo-and radiation therapies, and to discover new, and innovative treatment approaches [5, 6]. One popular strategy is the engineering of redox-sensitive nanomaterials with th","cbCaimbzjQ21ijcu","https://ap.wps.com/l/cbCaimbzjQ21ijcu","pdf",1830755,34,"English","# Abstract\n## Nanoceria dual-catalytic rationale and therapeutic mechanisms\n# Keywords\n# Introduction\n## Cancer burden and treatment challenges\n## Role of ROS in cancer biology\n## Targeting ROS regulation and tumour microenvironment","[{\"question\":\"What makes nanoceria suitable for cancer treatment?\",\"answer\":\"Nanoceria is cerium oxide nanoparticles with co-existing Ce3+ and Ce4+, enabling self-regenerative, redox-responsive dual-catalytic activity that modulates ROS for therapy.\"},{\"question\":\"How does nanoceria affect normal cells versus tumour cells?\",\"answer\":\"At physiological pH, nanoceria mimics ROS-related enzymes to protect normal cells from oxidative stress, while in the slightly acidic tumour microenvironment it promotes ROS production to trigger cancer cell death.\"},{\"question\":\"Why does alleviating tumour hypoxia matter for therapy outcomes?\",\"answer\":\"Nanoceria can generate molecular oxygen, relieving tumour hypoxia and sensitising tumour cells, improving outcomes across PDT, PTT, radiation, targeted and chemotherapies.\"}]","Nanoceria: an innovative strategy for cancer treatment | PDF",1790248573,86]