[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-417215-105":59,"doc-detail-417215-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","myxoid-pleomorphic-liposarcoma-a-review-and-update","Myxoid Pleomorphic Liposarcoma: A Review and Update","","Myxoid pleomorphic liposarcoma (MPLPS) is an extremely rare, recently recognized adipocytic neoplasm mainly affecting children and young adults, with a marked predilection for the mediastinum. It shows aggressive clinical behavior, frequent systemic spread, and poor overall survival; some cases relate to Li-Fraumeni syndrome. Histology combines myxoid and pleomorphic components, with CD34 and p16 diffuse expression and RB pathway alterations. Surgical excision with negative margins is central for localized disease, while advanced cases remain therapeutically challenging.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/myxoid-pleomorphic-liposarcoma-a-review-and-update/417215/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/myxoid-pleomorphic-liposarcoma-a-review-and-update/417215.png","ImageObject",300,407,{"name":92,"@type":93},"OmBimo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is myxoid pleomorphic liposarcoma (MPLPS) and who does it affect?","Question",{"text":112,"@type":113},"MPLPS is an exceedingly rare, highly aggressive adipocytic neoplasm. It primarily occurs in children and young adults, and can also be seen in older patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What pathological and immunohistochemical findings characterize MPLPS?",{"text":117,"@type":113},"Histologically, MPLPS contains a variable mixture of myxoid and pleomorphic liposarcoma-like components. Immunohistochemically, tumor cells show diffuse CD34 and p16 expression and loss of nuclear RB expression.",{"name":119,"@type":110,"acceptedAnswer":120},"How is localized MPLPS typically treated and what challenges exist for advanced disease?",{"text":121,"@type":113},"For localized MPLPS, surgical excision with negative margins is the mainstay. For advanced or metastatic disease, there is no standardized systemic treatment and chemotherapy/radiotherapy roles are difficult to define.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},417215,1791431740,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090893581,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","doi: 10.21873/cgp.20557  \nReview  \nMyxoid Pleomorphic Liposarcoma: A Review and Update  \nJUN NISHIO1, SHIZUHIDE NAKAYAMA2 and MIKIKO AOKI3  \n1Section of Orthopaedic Surgery, Department of Medicine, Fukuoka Dental College, Fukuoka, Japan;  \n2 Nakayama Orthopaedic Clinic, Fukuoka, Japan;  \n3 Department of Pathology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan  \nAbstract  \nMyxoid pleomorphic liposarcoma (MPLPS) is an exceedingly rare and recently recognized adipocytic neoplasm that primarily occurs in children and young adults and shows a strong predilection for the mediastinum. Clinically, MPLPS demonstrates aggressive behavior and exhibits a high propensity for systemic spread anda worse overall survival. Some cases have been associated with Li-Fraumeni syndrome. Histologically, MPLPS is composed of a variable mixture of myxoidandpleomorphicliposarcoma-like components. Immunohistochemically, the tumor cells show diffuse expression of CD34 and p16 and loss of nuclear RB expression. MPLPS lacks DNA damage inducible transcript 3 (DDIT3) rearrangementsand MDM2 proto-oncogene (MDM2) amplifications but shows tumor protein p53 (TP53) mutations and RB transcriptional co-repressor 1 (RB1) deletions. Moreover, recent studies have demonstrated that the most consistent molecular feature of MPLPS is genome-wide loss of heterozygosity. Surgical excision with negative margins is the mainstay of treatment for localized MPLPS. The treatment of advanced/metastatic MPLPS still poses a huge therapeutic challenge. This review provides information about the clinicoradiological features, pathogenesis, histopathology, and management currently available for MPLPS. In addition, we discuss the differential diagnosis of this novel entity.  \nKeywords: Myxoid pleomorphicliposarcoma, myxoidliposarcoma, pleomorphicliposarcoma, atypical spindle-cell/ pleomorphic lipomatous tumor, dedifferentiated liposarcoma, treatment, RB1, TP53, review.  \nIntroduction  \nMyxoid pleomorphic liposarcoma (MPLPS) is an extremely rare and highly aggressive adipocytic neoplasm characterized by the presence of hybrid morphological features of conventional myxoidliposarcoma (MLPS) and pleomorphic  \nliposarcoma (PLPS) (1). MPLPS can be challenging to diagnose due to its rarity and histological overlap with diverse mimics. In 2009, Alaggioetal. (2) described 12 cases of LPS with admixture of histological features of MLPS and PLPS inpatients below 22 years of age and proposed the term“pleomorphic myxoidliposarcoma”, with aggressive behavior.  \n✉ Jun Nishio, MD, PhD, Section of Orthopaedic Surgery, Department of Medicine, Fukuoka  \nSawara-ku, Fukuoka 814-0193, Japan. Tel: +81 928010411, Fax: +81 928010735, e-mail:  \nReceived September 4, 2025 | Revised October 1, 2025 | Accepted October 2, 2025  \nDental College, 2-15-1 Tamura, [nishio@fdcnet.ac.jp](nishio@fdcnet.ac.jp)  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n©2026 The Author(s) . Anticancer Research is published by the International Institute of Anticancer Research.  \nMPLPS was initially regarded asa high-grade variant of MLPS. In 2012, Boland et al. (3) postulated that MPLPS could possibly represent an unusual morphological variant of PLPSon the basis of molecular features including lack of DNA damage-inducible transcript 3 (DDIT3) rearrangements. This molecular finding was confirmed in subsequent studies by Creytens etal. (4) and Hofvander etal. (5). In 2020, MPLPS was first listed in the fifth edition of the World Health Organization Classification of Soft Tissue and Bone Tumors (1). Recent clinicopathological and genomic studies support the notion that MPLPSisa distinct subtype of LPS (6, 7). The etiology of this peculiar neoplasm is unknown. Surgical excision is the prioritized management of localized MPLPS. It is currently difficult to definitively establis","cbCainSQWn0fm6Ly","https://ap.wps.com/l/cbCainSQWn0fm6Ly","pdf",449828,11,"English","# Abstract\n# Introduction\n# Clinical Features and Prognosis\n# Diagnosis and Pathogenesis\n# Histopathology and Immunohistochemistry\n# Molecular Features\n# Treatment and Management\n# Differential Diagnosis","[{\"question\":\"What is myxoid pleomorphic liposarcoma (MPLPS) and who does it affect?\",\"answer\":\"MPLPS is an exceedingly rare, highly aggressive adipocytic neoplasm. It primarily occurs in children and young adults, and can also be seen in older patients.\"},{\"question\":\"What pathological and immunohistochemical findings characterize MPLPS?\",\"answer\":\"Histologically, MPLPS contains a variable mixture of myxoid and pleomorphic liposarcoma-like components. Immunohistochemically, tumor cells show diffuse CD34 and p16 expression and loss of nuclear RB expression.\"},{\"question\":\"How is localized MPLPS typically treated and what challenges exist for advanced disease?\",\"answer\":\"For localized MPLPS, surgical excision with negative margins is the mainstay. For advanced or metastatic disease, there is no standardized systemic treatment and chemotherapy/radiotherapy roles are difficult to define.\"}]","Myxoid Pleomorphic Liposarcoma: A Review and Update | PDF",1790608434,28]