[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-351694-105":59,"doc-detail-351694-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","myeloid-mir34a-suppresses-initiation-and-progression-of-intestinal-and-colitis-induced-colon-cancers-in-apcmin-mice","Myeloid Mir34a suppresses initiation and progression of intestinal and colitis-induced colon cancers in APCmin mice","","Myeloid Mir34a acts as a tumor suppressor in ApcMin/+ mice, limiting initiation and preventing progression of intestinal and colitis-induced colon cancers. Myeloid-specific Mir34a deletion increases tumor initiation and enables invasive carcinoma development, while promoting TAM polarization toward a pro-tumorigenic M2-like phenotype. Mir34a loss also enhances migration and M2-like marker expression in bone-marrow-derived macrophages, elevates immunosuppressive CD4+Foxp3+ Treg cells, and reduces survival after colitis induction, indicating an anti-tumor immune-state governed by the p53-miR-34a axis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/myeloid-mir34a-suppresses-initiation-and-progression-of-intestinal-and-colitis-induced-colon-cancers-in-apcmin-mice/351694/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/myeloid-mir34a-suppresses-initiation-and-progression-of-intestinal-and-colitis-induced-colon-cancers-in-apcmin-mice/351694.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the role of myeloid Mir34a in APCmin/+ tumor development?","Question",{"text":112,"@type":113},"Myeloid Mir34a suppresses tumor initiation and progression in ApcMin/+ mice. Deleting Mir34a in myeloid cells increases tumor initiation and allows progression toward invasive carcinomas.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does Mir34a loss affect immune cell phenotypes in tumors?",{"text":117,"@type":113},"Mir34a deficiency promotes pro-tumorigenic polarization of tumor-associated macrophages toward a M2-like state and increases immunosuppressive CD4+Foxp3+ Treg cells. It also shifts the tumor environment after inflammatory colitis toward increased M2-like TAMs.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanisms and pathways are implicated by these findings?",{"text":121,"@type":113},"The study links antitumor suppression to maintenance of myeloid and T-cells in an antitumorigenic state. It highlights a central role for the p53-miR-34a axis in non-tumor cell mediated suppression of intestinal and colon cancers.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},351694,1790177736,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www.nature.com/cddis](www.nature.com/cddis)  \nARTICLE OPEN   \nMyeloid Mir34a suppresses initiation and progression of intestinal and colitis-induced colon cancers in APCmin mice  \nYun Chen 1,4, Fangteng Liu1,4, Janine König 1,4, Nassim Bouznad 1 and Heiko Hermeking 1,2,3 ✉  \n© The Author(s) 2026  \n\n|  |  |  |\n| --- | --- | --- |\n|  | Here we determined whether myeloid Mir34a has a tumor suppressive function in ApcMin/+ mice, a model for intestinal and colon cancer. Myeloid cell-specific deletion of Mir34a in ApcMin/+ mice increased tumor initiation and allowed progression towards invasive carcinomas, which are generally not observed in ApcMin/+ mice. Loss of Mir34a facilitated the polarization of tumorassociated macrophages (TAMs) towards a pro-tumorigenic M2-like state, implying that Mir34a is required to maintain TAMs in a tumor-suppressive state. Also, Mir34a-deficient, bone-marrow-derived macrophages (BMDMs) from ApcMin/+ mice were polarized towards a pro-tumorigenic, M2-like state and displayed enhanced migration when compared to Mir34a-proficient BMDMs. Intestinal tumors in myeloid Mir34a-deficient mice showed elevated expression of several known Mir34a target mRNAs, including Csf1r, Pd-l1, Mmp9, Ccl22, and c-Myc. In addition, the number of immuno-suppressive, pro-tumorigenic CD4+Foxp3+ Treg cells increased in myeloid Mir34a-deficient intestinal tumors. Moreover, ApcMin/+ mice with myeloid-specific deletion of Mir34a had asignificantly diminished survival rate. Following the induction of inflammatory colitis, these mice showed enhanced colon cancer initiation and progression towards invasive carcinomas with an increase in M2-like TAMs, N2-like neutrophils and Treg cells. These findings imply that myeloid Mir34a suppresses tumor formation and progression by maintaining myeloid and T-cells in an antitumorigenic state. Therefore, the p53-miR-34a axis has a central role in non-tumor cell mediated suppression of intestinal and colon |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  | cancers. |  |\n|  |  |  |\n|  |  |  |\n|  | Cell Death and Disease (2026)17:458; [https://doi.org/10.1038/s41419-026-08851-6](https://doi.org/10.1038/s41419-026-08851-6) |  |\n|  |  |  |\n\nINTRODUCTION  \nThe tumor microenvironment (TME) affects tumor initiation, progression and metastasis. In the recent years a complex interplay between cancer cells and diverse, non-malignant cell types present in the tumor micro-environment (TME) has been described: tumor-associated macrophages (TAMs), neutrophils (TANs) and myeloid-derived suppressor cells display immunosuppressive characteristics [1, 2], and have been associated with immunotherapy efficacy [3], as well as pre-metastatic niche formation [4] . TAMs and TANs have dual roles with both, tumorpromoting and tumor-restraining functions during tumor development, depending on their polarization state [5, 6]: M2-like TAMsand N2-like TANs facilitate tumor growth by promoting angiogenesis, metastasis and suppressing immune-responses towards the tumor. In contrast, M1-like TAMs and N1-like TANs exhibit proinflammatory and immune-stimulating activities, thereby enhancing an immune reaction against the tumor [7–9] . Therefore, selectively blocking or reprogramming TAMs and TANs in these  \nstates may represent an attractive therapeutic strategy [10] . The p53 tumor suppressor gene encodes a transcription factor, which is activated by multiple extracellular and cellular stress signals. The p53 gene is inactivated by mutations in approximately half of all human cancers [11–13] and in around 80% of advanced  \ncolorectal cancer (CRC) [14] . p53 has also been implicated in immunogenic processes and may be involved in antitumor immunity [15, 16] .  \nThe miR-34a gene is directly induced by p53 and encodes amicroRNA with multiple tumor suppressive functions [17] . We have previously shown that intestinal-cell specific deletion of Mir3","cbCaipgyWGcnKSOt","https://ap.wps.com/l/cbCaipgyWGcnKSOt","pdf",18082155,15,"English","# Introduction\n## Tumor microenvironment and myeloid cell polarization\n## p53 and miR-34a axis in tumor suppression\n## Study aim and experimental premise\n# Materials and Methods\n## Generation and handling of mice","[{\"question\":\"What is the role of myeloid Mir34a in APCmin/+ tumor development?\",\"answer\":\"Myeloid Mir34a suppresses tumor initiation and progression in ApcMin/+ mice. Deleting Mir34a in myeloid cells increases tumor initiation and allows progression toward invasive carcinomas.\"},{\"question\":\"How does Mir34a loss affect immune cell phenotypes in tumors?\",\"answer\":\"Mir34a deficiency promotes pro-tumorigenic polarization of tumor-associated macrophages toward a M2-like state and increases immunosuppressive CD4+Foxp3+ Treg cells. It also shifts the tumor environment after inflammatory colitis toward increased M2-like TAMs.\"},{\"question\":\"What mechanisms and pathways are implicated by these findings?\",\"answer\":\"The study links antitumor suppression to maintenance of myeloid and T-cells in an antitumorigenic state. It highlights a central role for the p53-miR-34a axis in non-tumor cell mediated suppression of intestinal and colon cancers.\"}]","Myeloid Mir34a suppresses initiation and progression of intestinal and colitis-induced colon cancers in APCmin mice | PDF",1790095377,38]