[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-326668-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-326668-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","mutational-profiling-of-mitochondrial-dna-reveals-an-epithelial-ovarian-cancer-specific-evolutionary-pattern-contributing-to-high-oxidative-metabolism","Mutational profiling of mitochondrial DNA reveals an epithelial ovarian cancer-specific evolutionary pattern contributing to high oxidative metabolism","","Epithelial ovarian cancer (EOC) depends strongly on oxidative phosphorylation and shows characteristic mitochondrial metabolic reprogramming. This research systematically characterizes somatic mitochondrial DNA (mtDNA) mutation evolutionary patterns across EOC tissues and evaluates their roles in metabolic remodelling. Using a large mtDNA mutation dataset from private and public EOC cohorts, the study links EOC with marked mitochondrial genome instability and specific heteroplasmy accumulation dynamics, and associates mutation profiles with mitochondrial biogenesis and patient prognosis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/mutational-profiling-of-mitochondrial-dna-reveals-an-epithelial-ovarian-cancer-specific-evolutionary-pattern-contributing-to-high-oxidative-metabolism/326668/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/mutational-profiling-of-mitochondrial-dna-reveals-an-epithelial-ovarian-cancer-specific-evolutionary-pattern-contributing-to-high-oxidative-metabolism/326668.png","ImageObject",300,407,{"name":42,"@type":43},"Jiven","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What central problem does the study address in epithelial ovarian cancer?","Question",{"text":63,"@type":64},"The study addresses how somatic mtDNA mutations evolve in EOC tissues and how these patterns may contribute to mitochondrial metabolic remodelling.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What data sources and scale were used for the mutational analysis?",{"text":68,"@type":64},"The analysis used a large somatic mtDNA mutation dataset combining private and public EOC cohorts, totaling 239 and 118 patients, respectively.",{"name":70,"@type":61,"acceptedAnswer":71},"What key evolutionary features of mtDNA mutations were found in EOC tissues?",{"text":72,"@type":64},"EOC mitochondrial genomes were more unstable than non-cancerous ovarian tissues, with delayed heteroplasmy accumulation of mtDNA control region mutations and near-absence of mtCTR nonhypervariable segment mutations, consistent with stringent negative selection.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},326668,1790530113,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","DOI: 10.1002/ctm2.1523  \nRESEARCH ARTICLE  \nMutational profiling of mitochondrial DNA reveals an epithelial ovarian cancer-specific evolutionary pattern contributing to high oxidative metabolism  \nFanfan Xie1,2  Wenjie Guo2   Xingguo Wang1  Kaixiang Zhou2   \nShanshan Guo2  Yang Liu2  Tianlei Sun2  Shengjing Li2  Zhiyang Xu1  Qing Yuan3  Huanqin Zhang2  Xiwen Gu4  Jinliang Xing2   Shujuan Liu1  \n1 Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi’an, China  \n2 State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi’an, China  \n3 Institute of Medical Research, Northwestern Polytechnical University, Xi’an, China  \n4 State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, China  \nCorrespondence  \nShujuan Liu, Department of Obstetricsand Gynecology, Xijing Hospital, Fourth Military Medical University, Xi’an, China. [Email:](Email: hanliu@fmmu.edu.cn)[ hanliu@fmmu.edu.cn](Email: hanliu@fmmu.edu.cn)  \nJinliang Xing, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi’an, China. [Email:](Email: xingjl@fmmu.edu.cn)[ xingjl@fmmu.edu.cn](Email: xingjl@fmmu.edu.cn)  \nGraphical Abstract  \nThis study provides a comprehensive delineation of EOC-specific evolutionary patterns of mtDNA mutations based on large-scale sample sequencing of the mitochondrial genome, which aligned well with specific mitochondrial metabolic remodelling. The mtDNA mutations were significantly associated with both mitochondrial biogenesis and prognosis of EOC patients, conferring novel insights into the functional roles of mtDNA mutations in EOC tumourigenesis and progression.  \nClin. Transl. Med. 2024;14:e1523 .  \n[https://doi.org/10.1002/ctm2.1523](https://doi.org/10.1002/ctm2.1523)  \n[wileyonlinelibrary.com/journal/ctm2](wileyonlinelibrary.com/journal/ctm2)  \nDOI: 10.1002/ctm2.1523  \nRESEARCH ARTICLE  \nMutational profiling of mitochondrial DNA reveals an epithelial ovarian cancer-specific evolutionary pattern contributing to high oxidative metabolism  \nFanfan Xie1,2  Wenjie Guo2   Xingguo Wang1  Kaixiang Zhou2   \nShanshan Guo2  Yang Liu2  Tianlei Sun2  Shengjing Li2  Zhiyang Xu1  Qing Yuan3  Huanqin Zhang2  Xiwen Gu4  Jinliang Xing2   Shujuan Liu1  \n1 Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi’an, China  \n2 State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi’an, China  \n3 Institute of Medical Research, Northwestern Polytechnical University, Xi’an, China  \n4 State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, China  \nCorrespondence  \nShujuan Liu, Department of Obstetricsand Gynecology, Xijing Hospital, Fourth Military Medical University, Xi’an, China. [Email:](Email: hanliu@fmmu.edu.cn)[ hanliu@fmmu.edu.cn](Email: hanliu@fmmu.edu.cn)  \nJinliang Xing, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi’an, China. [Email:](Email: xingjl@fmmu.edu.cn)[ xingjl@fmmu.edu.cn](Email: xingjl@fmmu.edu.cn)  \nFunding information  \nNational Natural Science Foundation of China, Grant/Award Numbers: 81830070, 82273376; Key Research and Development Projects in Shaanxi Province,  \nGrant/Award Number: 2023-ZDLSF-46; Autonomous Project of State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, China, Grant/Award Nu","cbCaihFK8Y2QWkyp","https://ap.wps.com/l/cbCaihFK8Y2QWkyp","pdf",5366571,18,"English","# Abstract\n## Background\n## Methods\n## Results","[{\"question\":\"What central problem does the study address in epithelial ovarian cancer?\",\"answer\":\"The study addresses how somatic mtDNA mutations evolve in EOC tissues and how these patterns may contribute to mitochondrial metabolic remodelling.\"},{\"question\":\"What data sources and scale were used for the mutational analysis?\",\"answer\":\"The analysis used a large somatic mtDNA mutation dataset combining private and public EOC cohorts, totaling 239 and 118 patients, respectively.\"},{\"question\":\"What key evolutionary features of mtDNA mutations were found in EOC tissues?\",\"answer\":\"EOC mitochondrial genomes were more unstable than non-cancerous ovarian tissues, with delayed heteroplasmy accumulation of mtDNA control region mutations and near-absence of mtCTR nonhypervariable segment mutations, consistent with stringent negative selection.\"}]","Mutational profiling of mitochondrial DNA reveals an epithelial ovarian cancer-specific evolutionary pattern contributing to high oxidative metabolism | PDF",1789975056,45]