[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-332110-en":59,"doc-seo-332110-105":81},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":72,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":80,"preview_page_count":4},332110,549758252649,"Ivy","https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Mutational landscape of HSP family on human breast cancer","Study evaluates mutational changes affecting the Heat Shock Protein (HSP) family in human breast cancer (BRCA), using mainly TCGA data. BRCA is discussed as five intrinsic molecular subtypes based on PAM50, while HSP genes (95 total) are linked to proteostasis and cancer biology. Copy number variations (CNV) emerge as the most frequent alterations, with Basal showing the highest amplified CNV and Luminal tumors accumulating deletion CNV; HER2 shows lower CNV frequency. Integrating CNV and expression data reveals associations and CNV-driven deregulation of HSP expression. CNV profiles are identified as prognostic risk markers, supported by AI-based patient clustering and a molecular CNV signature independent of classic PAM50 subtypes, informing personalized treatment strategy development.","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nMutational landscape of HSP family on human breast cancer  \nJuan Manuel Fernandez‑Muñoz1,2, Martin Eduardo Guerrero‑Gimenez1,2,  \nLeonardo Andrés Ciocca3, María José Germanó1,2 & Felipe Carlos Martin Zoppino1,2*  \nBreast cancer (BRCA) is a prevalent malignancy with the highest incidence among females. BRCA can be categorized into five intrinsic molecular subtypes (LumA, LumB, HER2, Basal, and Normal), each characterized by varying molecular and clinical features determined by the expression of intrinsic genes (PAM50). The Heat Shock Protein (HSP) family is composed of 95 genes evolutionary conservated, they have critical roles in proteostasis in both normal and cancerous processes. Many studies have linked HSPto the development and spread of cancer. They modulate the activity of multiple proteins expressed by oncogenes and anti‑oncogenes through a range of interactions. In this study, we evaluate the mutational changes that HSP undergoes in BRCA mainly from theTCGA database. We observe that Copy Number Variations (CNV) are the more frequent events analyzed surpassing the occurrence of point mutations, indels, and translation start site mutations. The Basal subtype showcased the highest count of amplified CNV, including subtype‑specific changes, whereas the Luminals tumors accumulated the greatest number of deletion CNV. Meanwhile, the HER2 subtype exhibited a comparatively lower frequency ofCNV alterations when compared to the other subtypes. This study integrates CNV and expression data, finding associations between these two variables and the influence of CNV on the deregulation of HSP expression. To enhance the role of HSP as a risk predictor in BRCA, we succeeded in identifying CNV profiles as a prognostic marker. We included Artificial Intelligence to improve the clustering of patients, and we achieved a molecular CNV signature as a significant risk factor independent of known classic markers, including molecular subtypes PAM50. This research enhances the comprehension of HSP DNA alterations in BRCA and its relation with predicting the risk of affected individuals providing insights to develop guide personalized treatment strategies.  \nBreast cancer (BRCA) is a global public health issue highlighted by age-standardized incidence and mortality rates of 47.8 and 13.6, respectively1. According to molecular aspects, BRCA can be divided into five intrinsic subtypes (Luminal A, Luminal B, Basal, HER2, and Normal-like), each exhibiting distinct clinical characteristics. The potential of this classification method to stratify breast cancer cases and enable tailored treatment strategies makes it a vital tool in clinical practice2,3. The Heat Shock Protein family (HSP) is composed of 95 genes subdivided into five subfamilies4, these genes play critical roles in proteostasis in both normal and cancerous states. Many members ofthe HSP family have been extensively studied on relevant pathways of cancer hallmarks5,6. We have previously described the deregulation of various HSP in BRCA, identifying both up-regulated genes and others that are strongly repressed. We demonstrated that multiple members ofthe HSP family are closely associated with patient survival and are expressed in characteristic patterns, enabling the identification of three subtypes of HSP patients that are also associated with patient outcomes7. Genetic variations in the human genome encompass abroad range of alterations, spanning from large-scale chromosomal anomalies (loss of chromosomes or segmentalaneuploidy) to small-scale single nucleotide variants (SNP)8. From this vantage point, extensive research has been dedicated to investigating DNA alterations that have the potential to impact on tumoral process. In pursuit of this objective, SNP have emerged as the most extensively studied mutations, revealing associations with various types of cancer as well as other genetic disorders. As we ","cbCaisKjEkJD7jxo","https://ap.wps.com/l/cbCaisKjEkJD7jxo","pdf",3142350,14,"English","en",105,"# Introduction\n## Breast cancer subtypes and molecular classification\n## HSP family roles in proteostasis and cancer\n## DNA alterations and the relevance of CNV\n# Results\n## HSP family alteration patterns across subtypes\n## CNV-driven HSP deregulation and risk prediction","[{\"question\":\"Which data sources are used to assess HSP mutational changes in BRCA?\",\"answer\":\"The study evaluates mutational changes mainly using the TCGA database and also incorporates TCGA and METABRIC cohorts in the analysis of the full HSP family in BRCA.\"},{\"question\":\"What type of mutation is reported as most frequent in the analysis?\",\"answer\":\"Copy number variations (CNV) are reported as the most frequent events, surpassing point mutations, indels, and translation start site mutations.\"},{\"question\":\"How do CNV patterns differ across BRCA intrinsic subtypes for HSP?\",\"answer\":\"Basal subtype shows the highest count of amplified CNV with subtype-specific changes, Luminal tumors accumulate the greatest number of deletion CNV, and HER2 has a comparatively lower CNV alteration frequency than other subtypes.\"},{\"question\":\"How is a prognostic risk marker for HSP/CNV developed in the study?\",\"answer\":\"The research integrates CNV and expression data to link CNV with HSP expression deregulation, then identifies CNV profiles as prognostic markers. Artificial intelligence is used to improve patient clustering and derive a molecular CNV signature that is a significant risk factor independent of classic PAM50 markers.\"}]","Mutational landscape of HSP family on human breast cancer | PDF",1789996830,35,{"code":4,"msg":82,"data":83},"ok",{"site_id":75,"language":74,"slug":84,"title":65,"keywords":85,"description":66,"schema_data":86,"social_meta":144,"head_meta":146,"extra_data":148,"updated_unix":149},"mutational-landscape-of-hsp-family-on-human-breast-cancer","",{"@graph":87,"@context":143},[88,102,122],{"@type":89,"itemListElement":90},"BreadcrumbList",[91,95,97,100],{"item":92,"name":93,"@type":94,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":96,"name":9,"@type":94,"position":14},"https://docshare.wps.com/document/",{"item":98,"name":40,"@type":94,"position":99},"https://docshare.wps.com/document/research-report/",3,{"item":101,"name":65,"@type":94,"position":19},"https://docshare.wps.com/document/mutational-landscape-of-hsp-family-on-human-breast-cancer/332110/",{"url":101,"name":65,"@type":103,"image":104,"author":109,"headline":65,"publisher":111,"fileFormat":114,"inLanguage":74,"description":66,"dateModified":115,"datePublished":116,"encodingFormat":114,"isAccessibleForFree":117,"interactionStatistic":118},"DigitalDocument",{"url":105,"@type":106,"width":107,"height":108},"https://docshare.wps.com/thumbnails/mutational-landscape-of-hsp-family-on-human-breast-cancer/332110.png","ImageObject",300,407,{"name":63,"@type":110},"Person",{"url":92,"name":112,"@type":113},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":119,"interactionType":120,"userInteractionCount":19},"InteractionCounter",{"@type":121},"ViewAction",{"@type":123,"mainEntity":124},"FAQPage",[125,131,135,139],{"name":126,"@type":127,"acceptedAnswer":128},"Which data sources are used to assess HSP mutational changes in BRCA?","Question",{"text":129,"@type":130},"The study evaluates mutational changes mainly using the TCGA database and also incorporates TCGA and METABRIC cohorts in the analysis of the full HSP family in BRCA.","Answer",{"name":132,"@type":127,"acceptedAnswer":133},"What type of mutation is reported as most frequent in the analysis?",{"text":134,"@type":130},"Copy number variations (CNV) are reported as the most frequent events, surpassing point mutations, indels, and translation start site mutations.",{"name":136,"@type":127,"acceptedAnswer":137},"How do CNV patterns differ across BRCA intrinsic subtypes for HSP?",{"text":138,"@type":130},"Basal subtype shows the highest count of amplified CNV with subtype-specific changes, Luminal tumors accumulate the greatest number of deletion CNV, and HER2 has a comparatively lower CNV alteration frequency than other subtypes.",{"name":140,"@type":127,"acceptedAnswer":141},"How is a prognostic risk marker for HSP/CNV developed in the study?",{"text":142,"@type":130},"The research integrates CNV and expression data to link CNV with HSP expression deregulation, then identifies CNV profiles as prognostic markers. Artificial intelligence is used to improve patient clustering and derive a molecular CNV signature that is a significant risk factor independent of classic PAM50 markers.","https://schema.org",{"og:url":101,"og:type":145,"og:title":65,"og:site_name":112,"og:description":66},"article",{"robots":147,"canonical":101},"index,follow",{"doc_id":61,"site_id":75},1790161556]