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These prostate cancer–associated circRNAs may support new biomarkers for early diagnosis and targeted therapy, though their roles are not fully clarified. The review consolidates molecular pathological functions of circRNAs and evaluates their translational potential for clinical treatment and prognostic assessment.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/multiple-roles-of-circular-rnas-in-prostate-cancer-from-the-biological-basis-to-potential-clinical-applications-review/370306/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/multiple-roles-of-circular-rnas-in-prostate-cancer-from-the-biological-basis-to-potential-clinical-applications-review/370306.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How do circular RNAs contribute to prostate cancer biology?","Question",{"text":63,"@type":64},"Circular RNAs can influence chemotherapy resistance and, consequently, disease progression in prostate cancer. The article highlights circRNAs as potential factors behind resistance mechanisms and clinical course.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What clinical applications of prostate cancer circRNAs does the review discuss?",{"text":68,"@type":64},"The article positions circRNAs as candidate biomarkers that could help improve early diagnosis and influence treatment prognosis, supporting development of strategies with fewer adverse effects and improved efficacy.",{"name":70,"@type":61,"acceptedAnswer":71},"Why are circRNAs considered promising despite not being fully understood yet?",{"text":72,"@type":64},"Studies indicate that prostate cancer–related circRNAs can play diverse regulatory roles, including oncogenic and suppressor functions. 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European Journal  \nEuropean Journal of Medical Research (2025) 30:140  \n[https://doi.org/10.1186/s40001-025-02382-0](https://doi.org/10.1186/s40001-025-02382-0 of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-025-02382-0 of Medical Research)  \n REVIEW Open Access  \nMultiple roles of circular RNAs in prostate   cancer: from the biological basis to potential clinical applications  \nXianping Zheng1†, Ling Song2†, Ce Cao3 and Shoutian Sun2*  \nAbstract  \nProstate cancer is an important health concern affecting men. Circular RNAs (circRNAs) play an important molecular biological role in regulating gene expression due to their unique structure. Studies have revealed the involvement of circRNAs in many human diseases. In prostate cancer, circRNAs can act as oncogenes or tumour suppressor genes and affect cancer cell proliferation, invasion, resistance to chemotherapy and, consequently, disease progression. Accordingly, prostate cancer-related circRNAs are expected to serve as new targets in early clinical diagnosis and targeted therapy, but the various roles of circRNAs in prostate cancer have not been fully elucidated. This article reviews the molecular pathological roles of circRNA in prostate cancer and explores its prospects as a translational medicine in clinical treatment and prognostic evaluation.  \nKeywords Prostate cancer, Circular RNAs, Chemotherapy resistance, Radiotherapy resistance  \nIntroduction  \nAccording to global cancer statistics, prostate cancer is now the second leading cause of cancer death in men after lung cancer. Globally, the numbers of new cases of prostate cancer and related deaths are expected to increase further over the next decade, with serious effects on men’s health. Significant geographical differences in incidence have been observed, with the highest rates in North America, Europe and Australia [1]. Both the incidence and mortality of prostate cancer have increased globally over the past few decades. These increases are due mainly to global population aging, increased  \n†Xianping Zheng and Ling Song should be considered as co-first authors.  \n*Correspondence: Shoutian Sun  \nsunstzb201 [1@163.com](1@163.com)  \n1 Intensive Care Unit, Zibo Central Hospital, Zibo 255024, China  \n2 Department of Emergency, Zibo Central Hospital, No. 54 Gongqingtuan Road, Zhangdian District, Zibo 255024, China  \n3 Department of Gastrointestinal Surgery, Zibo Central Hospital, Zibo 255024, China  \ndetection rates, changes in lifestyle and environmental factors [1, 2]. Clinically, prostate cancer can be stagedas either localised or progressive. For localised prostate cancer, the main treatment strategies include ablative radiotherapy and radical prostatectomy. Patients with progressive advanced prostate cancer are treated mainly using comprehensive methods, such as androgen deprivation therapy (ADT, also known as endocrine therapy), radiotherapy, chemotherapy and cellular immunotherapy. Each of these treatments is associated with serious adverse effects, including but not limited to cytotoxicity, peripheral neuropathy, urinary incontinence and erectile dysfunction. These adverse effects seriously reduce the quality of life of patients and are not ideal for many patients with advanced prostate cancer. Genetic variations have an important impact on disease occurrence. These variations can change the action pathways of androgens and the metabolism of testosterone. However, the molecular pathological mechanism underlying the onset and progression of prostate cancer remains unclear. Further exploration of the molecular biological  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative C","cbCaitJu7qAngCAc","https://ap.wps.com/l/cbCaitJu7qAngCAc","pdf",1028879,"English","# Abstract\n# Introduction\n# Overview of circular RNA (circRNA)","[{\"question\":\"How do circular RNAs contribute to prostate cancer biology?\",\"answer\":\"Circular RNAs can influence chemotherapy resistance and, consequently, disease progression in prostate cancer. The article highlights circRNAs as potential factors behind resistance mechanisms and clinical course.\"},{\"question\":\"What clinical applications of prostate cancer circRNAs does the review discuss?\",\"answer\":\"The article positions circRNAs as candidate biomarkers that could help improve early diagnosis and influence treatment prognosis, supporting development of strategies with fewer adverse effects and improved efficacy.\"},{\"question\":\"Why are circRNAs considered promising despite not being fully understood yet?\",\"answer\":\"Studies indicate that prostate cancer–related circRNAs can play diverse regulatory roles, including oncogenic and suppressor functions. However, the various roles of circRNAs in prostate cancer have not been fully elucidated, motivating further investigation.\"}]","Multiple roles of circular RNAs in prostate cancer: from the biological basis to potential clinical applications - Review | PDF",1790187906,23]