[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-353526-105":59,"doc-detail-353526-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","multiple-myeloma-risk-linked-to-dna-damage-response-genes","Multiple myeloma risk linked to DNA damage response genes","","Background DNA damage response genes (DDRG) are implicated in multiple cancers as risk factors and biomarkers for aggressiveness, yet their role in multiple myeloma (MM) remains insufficiently defined. Methods Disease associations of pathogenic variants were assessed across 3,446 MM cases and 323,233 cancer-free controls. Results Elevated MM risk correlated with inherited rare pathogenic mutations in TP53, ATM, CHEK2, KDM1A, and ARID1A, especially with early onset or family history; TP53/ATM germline carriers also showed poorer overall survival. Conclusions The findings broaden the DDRG phenotype to include MM and support targeted screening of higher-risk individuals.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multiple-myeloma-risk-linked-to-dna-damage-response-genes/353526/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multiple-myeloma-risk-linked-to-dna-damage-response-genes/353526.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-26","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which DNA damage response genes were linked to higher multiple myeloma risk?","Question",{"text":112,"@type":113},"Inherited rare pathogenic mutations in TP53, ATM, CHEK2, KDM1A, and ARID1A were associated with increased MM risk.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What study design was used to evaluate the genetic associations?",{"text":117,"@type":113},"The study analyzed pathogenic variants in nine candidate genes using 3,446 MM cases and 323,233 cancer-free controls.",{"name":119,"@type":110,"acceptedAnswer":120},"How did TP53 or ATM germline mutations relate to patient outcomes?",{"text":121,"@type":113},"Individuals with TP53 or ATM germline mutations were likely to have worse overall survival.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},353526,1790443892,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Conry etal. Journal of Hematology & Oncology (2026) 19:10 [https://doi.org/10.1186/s13045-025-01776-1](https://doi.org/10.1186/s13045-025-01776-1)  \nJournal of Hematology & Oncology  \nRESEARCH Open Access  \nMultiple myeloma risk linked to DNA damage  response genes  \nMichael Conry1, Irina Ostrovnaya2, Yelena Kemel1, Saloni Sinha1, Linda B. Baughn3, Brian Avery4, Kylee Maclachlan5, Victoria Groner1, Lauren Banaszak1, Aaron Norman6, Nicholas J. Boddicker6, Alyssa Clay-Gilmour7, Shaji Kumar8, Ellen Kim1, Sita Dandiker1, Mitul Waghmare1, Susan Slager6,8, Douglas W. Sborov4, Judy Garber9, Elizabeth E. Brown 10, Michelle Hildebrandt11, Parameshwaran Hari13, Nicola Camp4†, Celine Vachon6†, Saad Usmani5,12†, Kenneth Offit1,12† and Vijai Joseph1,12,14*†  \nAbstract  \nBackground DNA damage response genes (DDRG), implicated in several cancers as both predisposing risk factors as well as biomarkers for aggressiveness, have not been fully explored in multiple myeloma (MM) .  \nMethods Herein, we analyzed disease associations of pathogenic variations in nine putative candidate genes using 3 446 MM cases and 323 233 cancer-free controls.  \nResults Increased MM risk was found to be associated with inherited rare pathogenic mutations in TP53, ATM, CHEK2, KDM1A, and ARID1A, with an enrichment of these variants among individuals with early onset or family history of MM. Individuals with TP53 or ATM germline mutations are also likely to have worse overall survival.  \nConclusions Our results suggest expansion of the phenotypic spectrum of some of these DDRG to include MM. The identification of these germline predisposition genes opens the avenue for targeted screening of higher risk individuals especially those with young-onset or a family history of plasma cell gammopathies.  \nKeywords Cancer genetics, Cancer Prevention, Genetic Risk Factors, Germline Predisposition, Plasma Cell Neoplasms, Rare Pathogenic Variants, Cancer Predisposition Syndromes, Rare variants, Familial Hematologic Malignancies, Survival and Prognostic Biomarkers  \n†Nicola Camp, Celine Vachon, Saad Usmani, Kenneth Offit and Vijai Joseph contributed equally to this work.  \n*Correspondence:  \nVijai Joseph  \n[josephv@mskcc.org](josephv@mskcc.org)  \n1Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA  \n2Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA  \n3Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA  \n4Department of Internal Medicine, Huntsman Cancer Institute University of Utah, Salt Lake City, UT, USA  \n5Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA  \n6Department of Quantitative Health Science Research, Mayo Clinic, Rochester, MN, USA  \n7Department of Epidemiology & Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA  \n8Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, MN, USA  \n9Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA  \n10Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, USA  \n11Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, TX, USA  \n12Department of Medicine, Weill Cornell Medical College, New York, NY, USA  \n13Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA  \n141275 York Ave, Box 295, New York 10065, NY, USA  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless in","cbCaiumLbdDdExuA","https://ap.wps.com/l/cbCaiumLbdDdExuA","pdf",1918126,12,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"Which DNA damage response genes were linked to higher multiple myeloma risk?\",\"answer\":\"Inherited rare pathogenic mutations in TP53, ATM, CHEK2, KDM1A, and ARID1A were associated with increased MM risk.\"},{\"question\":\"What study design was used to evaluate the genetic associations?\",\"answer\":\"The study analyzed pathogenic variants in nine candidate genes using 3,446 MM cases and 323,233 cancer-free controls.\"},{\"question\":\"How did TP53 or ATM germline mutations relate to patient outcomes?\",\"answer\":\"Individuals with TP53 or ATM germline mutations were likely to have worse overall survival.\"}]","Multiple myeloma risk linked to DNA damage response genes | PDF",1790105925]