[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-421536-105":59,"doc-detail-421536-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","multimorbidity-as-a-predictor-of-mortality-in-companion-dogs","MULTIMORBIDITY AS A PREDICTOR OF MORTALITY IN COMPANION DOGS","","Multimorbidity—the co-occurrence of two or more diseases—rises with age and predicts mortality in humans, yet it is difficult to model in laboratory systems. Using companion dogs as a translational model, this study tracks over 50,000 dogs in the Dog Aging Project for up to five years. Accumulating multiple conditions increases mortality risk, with osteoarthritis or other degenerative joint diagnoses at entry predicting higher likelihood of multimorbidity.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multimorbidity-as-a-predictor-of-mortality-in-companion-dogs/421536/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multimorbidity-as-a-predictor-of-mortality-in-companion-dogs/421536.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What dataset and follow-up period were used in the study?","Question",{"text":112,"@type":113},"The study used the Dog Aging Project dataset, tracking over 50,000 dogs for up to five years.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does multimorbidity relate to mortality in companion dogs?",{"text":117,"@type":113},"As multiple conditions accumulate, dogs show an increased risk of mortality, similar to patterns observed in humans.",{"name":119,"@type":110,"acceptedAnswer":120},"Do specific baseline conditions predict later multimorbidity and mortality?",{"text":121,"@type":113},"Yes. Baseline diagnoses of osteoarthritis or other degenerative joint diseases were associated with higher diagnosis rates and a greater likelihood of developing multimorbidities, along with higher mortality risk.",{"name":123,"@type":110,"acceptedAnswer":124},"Why are disease combinations important in predicting mortality?",{"text":125,"@type":113},"The study found that particular co-morbid disease combinations were more strongly associated with mortality than the effect of individual diseases alone, exemplified by periodontal diseases together with heart murmurs.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},421536,1790741773,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":81},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","288 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.966  \nMULTIMORBIDITY AS A PREDICTOR AS MORTALITY  \nIN COMPANION DOGS  \nJessica Hoffman, Augusta University, Augusta, Georgia, United States  \nMultimorbidity, the co-occurrence of two or more diseases, increases with age and is a predictor of mortality in humans; however, modeling multimorbidity in laboratory models is difficult if not impossible. Here, we utilize the companion dog as a translational model of multimorbidity, tracking over 50,000 dogs in the Dog Aging Project (DAP) for up to five years. Similar to humans, we found that the accumulation of multiple conditions is associated with an increased risk of mortality in dogs. In addition, dogs with a diagnosis of osteoarthritis or other degenerative joint diseases at baseline entry into the DAP exhibited significantly higher diagnosis rates and a higher likelihood of developing multimorbidities. Interestingly, we then determined that specific co-morbid disease combinations were more likely to be associated with mortality than individual disease effects. For example, dogs with several periodontal diseases and heart murmurs were at an increased risk of death compared to dogs with either condition on its own. Overall, our study is the first to investigate the effects of multimorbidity on mortality in companion dogs, and future studies will attempt to determine if circulating biomarkers can predict future multimorbidity.","cbCaibiE08E28haO","https://ap.wps.com/l/cbCaibiE08E28haO","pdf",304038,"English","# Abstract\n## Study design and dataset\n## Key findings on multimorbidity risk\n## Disease combinations and mortality\n## Implications and future directions","[{\"question\":\"What dataset and follow-up period were used in the study?\",\"answer\":\"The study used the Dog Aging Project dataset, tracking over 50,000 dogs for up to five years.\"},{\"question\":\"How does multimorbidity relate to mortality in companion dogs?\",\"answer\":\"As multiple conditions accumulate, dogs show an increased risk of mortality, similar to patterns observed in humans.\"},{\"question\":\"Do specific baseline conditions predict later multimorbidity and mortality?\",\"answer\":\"Yes. Baseline diagnoses of osteoarthritis or other degenerative joint diseases were associated with higher diagnosis rates and a greater likelihood of developing multimorbidities, along with higher mortality risk.\"},{\"question\":\"Why are disease combinations important in predicting mortality?\",\"answer\":\"The study found that particular co-morbid disease combinations were more strongly associated with mortality than the effect of individual diseases alone, exemplified by periodontal diseases together with heart murmurs.\"}]","MULTIMORBIDITY AS A PREDICTOR OF MORTALITY IN COMPANION DOGS | PDF",1790625084]