[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-419682-105":59,"doc-detail-419682-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","multimodal-ultrasound-manifestations-of-a-central-intraductal-papilloma-at-the-nipple-and-its-causes-of-misdiagnosis-a-case-report","Multimodal Ultrasound Manifestations of a Central Intraductal Papilloma at the Nipple and Its Causes of Misdiagnosis - A Case Report","","Intraductal papillomas (IPs) arise from breast ductal epithelial cells and commonly present with serous or serosanguineous nipple discharge and sometimes palpable masses. A 59-year-old woman reported papillary lesions and nipple discharge for 20 years. Mammography and conventional ultrasound, including contrast-enhanced ultrasound, showed an irregular, poorly defined right-nipple mass, initially suggesting Paget’s disease. Biopsy confirmed IP, highlighting atypical presentation and the need for multimodal ultrasound to improve diagnostic accuracy and reduce misdiagnosis.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multimodal-ultrasound-manifestations-of-a-central-intraductal-papilloma-at-the-nipple-and-its-causes-of-misdiagnosis-a-case-report/419682/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multimodal-ultrasound-manifestations-of-a-central-intraductal-papilloma-at-the-nipple-and-its-causes-of-misdiagnosis-a-case-report/419682.png","ImageObject",300,407,{"name":92,"@type":93},"Kurz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What symptoms are commonly associated with intraductal papillomas (IPs)?","Question",{"text":113,"@type":114},"IPs commonly cause serous or serosanguineous nipple discharge and may be associated with palpable masses.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which imaging modalities were used in this case to evaluate the nipple lesion?",{"text":118,"@type":114},"The patient underwent mammography, conventional ultrasound, and contrast-enhanced ultrasound.",{"name":120,"@type":111,"acceptedAnswer":121},"What was the final diagnosis and how was it confirmed?",{"text":122,"@type":114},"The biopsy of the right papillary neoplasm confirmed intraductal papilloma, despite imaging findings initially raising concern for Paget’s disease.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},419682,1790740464,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336478945635,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Review began 11/14/2025  \nReview ended 11/22/2025  \nPublished 12/03/2025  \n© Copyright 2025  \nMingrui et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98355  \nOpen Access Case Report  \nMultimodal Ultrasound Manifestations of a Central Intraductal Papilloma at the Nipple and Its Causes of Misdiagnosis: A Case Report  \nChen Mingrui 1 , Xu XiaoHong 1, Zhong XinRong 1  \n1. Ultrasound Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, CHN Corresponding author: Xu XiaoHong, [13828297586@139.com](13828297586@139.com)  \nAbstract  \nIntraductal papillomas (IPs) are tumors arising from the ductal epithelial cells of the breast. Common symptoms associated with IPs include serous or serosanguineous nipple discharge and palpable masses. We present a case involving a 59-year-old female patient who experienced papillary lesions and nipple discharge for 20 years. Diagnostic imaging for this patient included mammography, conventional ultrasound, and contrast-enhanced ultrasound, which revealed an irregular and poorly defined mass at the right nipple. The ultrasound findings raised the possibility of Paget 's disease of the breast, while a biopsy of the right papillary neoplasm confirmed the diagnosis of an IP. The presentation of an IP as a neoplasm is uncommon. This article primarily discusses rare cases and examines multimodal ultrasound manifestations to enhance the predictive accuracy of diagnosing both benign and malignant breast lesions, thereby reducing the rate of misdiagnosis.  \nCategories: Other, Pathology, Oncology  \nKeywords: contrast-enhanced ultrasound, differential diagnosis, intraductal papilloma of the breast, pathological diagnosis, ultrasound examination  \nIntroduction  \nIntraductal papillomas (IPs) are benign tumors located within the mammary ducts. The abnormal proliferation of ductal epithelial cells contributes to tumor growth [1], and they can manifest in women across all age groups [2] . Histologically, IPs are characterized by a fibrovascular core enveloped by epithelial and myoepithelial cells [2] . Given their association with atypical ductal carcinoma in situ (DCIS) and breast cancer, these lesions are classified as high-risk precursor lesions [1] . Peripheral IPs are the most prevalent variant, typically situated in the periphery of any breast quadrant. In contrast, central IPs are generally located within the larger ducts of the subareolar region, often presenting as a solitary mass [1] . Occasionally, IP masses can be palpated. When the delicate epithelial cells within these masses rupture and bleed, they may result in bloody secretions from the papillae. Compared to the peripheral type, central IPs are more likely to induce spontaneous nipple discharge. The peripheral variant usually manifests as multiple lesions and infrequently causes nipple discharge [3] . Isolated IPs are commonly found in the central or regional area behind the areola [1], and the occurrence of papillary neoplasms associated with it is relatively uncommon. Currently, there are limited reports addressing related special manifestations. The detection of IPs primarily relies on conventional ultrasound examination. Differential diagnosis can be achieved through fine-needle aspiration biopsy, mammography, MRI, and other modalities; however, reports focusing solely on differential diagnosis via contrast-enhanced ultrasound are also scarce. This report presents the multimodal ultrasound manifestations of a case of IP of the breast with a unique location, as confirmed by pathology.  \nCase Presentation  \nA 59-year-old female patient presented to our hospital for treatment three days after the identification of papillary neoplasms associated with nipple discharge that had persisted for 20 years. Physi","cbCaiu9MTMmUzzG1","https://ap.wps.com/l/cbCaiu9MTMmUzzG1","pdf",4837779,"English","# Abstract\n# Introduction\n# Case Presentation\n# How to cite this article\n# Figure 1\n# Ultrasound examination findings","[{\"question\":\"What symptoms are commonly associated with intraductal papillomas (IPs)?\",\"answer\":\"IPs commonly cause serous or serosanguineous nipple discharge and may be associated with palpable masses.\"},{\"question\":\"Which imaging modalities were used in this case to evaluate the nipple lesion?\",\"answer\":\"The patient underwent mammography, conventional ultrasound, and contrast-enhanced ultrasound.\"},{\"question\":\"What was the final diagnosis and how was it confirmed?\",\"answer\":\"The biopsy of the right papillary neoplasm confirmed intraductal papilloma, despite imaging findings initially raising concern for Paget’s disease.\"}]","Multimodal Ultrasound Manifestations of a Central Intraductal Papilloma at the Nipple and Its Causes of Misdiagnosis - A Case Report | PDF",1790618027,15]