[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-462656-105":59,"doc-detail-462656-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","multimodal-personalized-treatment-of-pineal-region-tumors-in-adulthood-a-single-center-study","Multimodal, Personalized Treatment of Pineal Region Tumors in Adulthood - A Single Center Study","","Pineal region tumors represent a rare neuro-oncological challenge in adults, with limited established guidance and a need for multidisciplinary, multimodal care. This retrospective single-center study evaluates an institutional strategy combining endoscopic third ventriculostomy and tumor biopsy with personalized radiotherapy across 28 adult patients (2014–2025). Endoscopic intervention improved clinical status in 78% of cases and increased postoperative performance status. Radiotherapy enabled tumor regression or disease stabilization, supporting a safe, effective alternative to primary direct resection.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multimodal-personalized-treatment-of-pineal-region-tumors-in-adulthood-a-single-center-study/462656/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multimodal-personalized-treatment-of-pineal-region-tumors-in-adulthood-a-single-center-study/462656.png","ImageObject",300,407,{"name":92,"@type":93},"Pentious","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What treatment approach does the study evaluate for adult pineal region tumors?","Question",{"text":112,"@type":113},"The study evaluates an institutional multimodal strategy combining endoscopic third ventriculostomy and biopsy with personalized radiotherapy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many adult patients were included, and what period does the study cover?",{"text":117,"@type":113},"A total of 28 adult patients were included, covering procedures from January 2014 to March 2025.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key clinical outcomes after endoscopic intervention?",{"text":121,"@type":113},"Endoscopic intervention led to clinical improvement in 78% of cases, and postoperative performance status increased significantly compared with preoperative results.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},462656,1792223885,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374404730887,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Article  \nMultimodal, Personalized Treatment of Pineal Region Tumors in Adulthood—A Single Center Study  \nTamás Mezei 1, *, János Báskay 2,3, Péter Pollner 2,3, Lukács Németh 1, Balázs Markia 1, Gábor Nagy 1, András Bajcsay 4 and László Sipos 1  \nAcademic Editor: Milo Frattini  \nReceived: 19 September 2025  \nRevised: 1 December 2025  \nAccepted: 16 December 2025  \nPublished: 29 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Neurosurgery and Neurointervention, Semmelweis University, 1145 Budapest, Hungary  \n2 Data-Driven Health Division of National Laboratory for Health Security, Health Services Management Training Centre, Semmelweis University, 1125 Budapest, Hungary  \n3 Department of Biological Physics, Eötvös Loránd University, 1117 Budapest, Hungary  \n4 National Institute of Oncology, 1122 Budapest, Hungary  \n* [Correspondence: mezei.tamas@semmelweis.hu](Correspondence: mezei.tamas@semmelweis.hu); Tel.: +36-30-360-31-24  \nAbstract  \nBackground: Tumors of the pineal region account for less than 1% of supratentorial neoplasms in adults and represent a distinct neuro-oncological challenge. Their management requires a multidisciplinary and multimodal approach. Traditionally, direct surgical resection was considered the primary treatment modality. Recent advances in minimally invasive techniques and onco-radiotherapy have paved the way for safer and more personalized treatment strategies, in line with the principles of precision medicine. This study aims to present our institutional approach, which relies on a combination of endoscopic and radiotherapy-based techniques. Methods: A retrospective, single-center clinical study was conducted involving 28 adult patients who underwent endoscopic third ventriculostomy and biopsy of a pineal region tumor between January 2014 and March 2025 . Descriptive statistics, permutation tests with bootstrap-derived confidence intervals, Fisher’s exact test, and Kaplan–Meier survival analysis were applied for data evaluation. Results: Endoscopic intervention resulted in clinical improvement in 78% of cases. A significant increase in performance status was observed in the postoperative period (\u003C0.001) compared to preoperative results. Radiotherapy contributed to either tumor regression or disease stabilization. Conclusions: Based on our findings, the combination of endoscopic intervention and personalized radiotherapy represents a safe and effective treatment strategy, offering a compelling alternative to direct surgical resection, which is reserved as a second-line treatment.  \nKeywords: pineal tumors; endoscopic intervention; radiotherapy; radiosurgery; personalized therapy  \n1. Introduction  \nBecause of their anatomic location, tumors of the pineal region can present with a wide spectrum of clinical symptoms. However, almost all patients exhibit signs of disturbed cerebrospinal fluid (CSF) circulation and associated symptoms. Other possible manifestations include gaze palsy, endocrinological abnormalities (e.g., precocious puberty), and spinal symptoms in cases of drop metastases [1] .  \nThe surgical management of tumors located in the pineal region is an exceptionally complex and challenging task due to its deep, axial location and proximity to eloquent structures including the third ventricle, splenium of the corpus callosum, thalamus, lamina  \ntecti, and deep veins. The treatment is further complicated by the extreme rarity of these tumors, accounting for only 3–8% of pediatric central nervous system tumors and less than 1% of adult supratentorial tumors [2,3] . Moreover, the histological heterogeneity of tumors arising in this region adds to the complexity, with germinomas and astrocytomas predominating in children, while meningiomas and gliomas are more frequent in adults.  \nOwing to the rarity of the di","cbCaisxRG0zq86sB","https://ap.wps.com/l/cbCaisxRG0zq86sB","pdf",2557318,17,"English","# Abstract\n# Background\n# Methods\n# Results\n# Conclusions\n# Introduction","[{\"question\":\"What treatment approach does the study evaluate for adult pineal region tumors?\",\"answer\":\"The study evaluates an institutional multimodal strategy combining endoscopic third ventriculostomy and biopsy with personalized radiotherapy.\"},{\"question\":\"How many adult patients were included, and what period does the study cover?\",\"answer\":\"A total of 28 adult patients were included, covering procedures from January 2014 to March 2025.\"},{\"question\":\"What were the key clinical outcomes after endoscopic intervention?\",\"answer\":\"Endoscopic intervention led to clinical improvement in 78% of cases, and postoperative performance status increased significantly compared with preoperative results.\"}]","Multimodal, Personalized Treatment of Pineal Region Tumors in Adulthood - A Single Center Study | PDF",1790764811,43]