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This study synthesizes two multifunctional zwitterionic carboxymethyl cellulose hydrogels (VCS/Ag/CMC and ACS/Ag/CMC) incorporating silver nanowires. Structural characterization confirms zwitterionic component integration and uniform nanowire distribution, yielding strong mechanics, high swelling, controlled degradability, and sustained Ag release. In vitro results show potent antibacterial and antioxidant performance; in vivo studies demonstrate accelerated closure, improved re-epithelialization, collagen deposition, neovascularization, and M2 macrophage polarization toward pro-healing regenerative outcomes.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multifunctional-carboxymethyl-cellulose-based-hydrogels-with-zwitterionic-and-silver-nanowire-components-for-wound-management/453970/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multifunctional-carboxymethyl-cellulose-based-hydrogels-with-zwitterionic-and-silver-nanowire-components-for-wound-management/453970.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-10","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What hydrogels were synthesized for chronic wound management?","Question",{"text":113,"@type":114},"Two multifunctional zwitterionic hydrogels were synthesized: VCS/Ag/CMC and ACS/Ag/CMC, both based on carboxymethyl cellulose and incorporating silver nanowires.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What key material characteristics support chronic wound application?",{"text":118,"@type":114},"The hydrogels show favorable mechanics, high swelling capacity, controlled degradability, and sustained silver release, with uniform nanowire distribution confirmed by structural analyses.",{"name":120,"@type":111,"acceptedAnswer":121},"How do the hydrogels perform in biological studies?",{"text":122,"@type":114},"In vitro, they exhibit strong antibacterial and antioxidant activities; in vivo, they accelerate wound closure, enhance re-epithelialization, increase collagen deposition and neovascularization, and promote M2 macrophage polarization.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},453970,1790945076,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","iScience Article  \nMultifunctional carboxymethyl cellulose-based hydrogels with zwitterionic and silver nanowire components for wound management  \nAuthors  \nKit-Leong Cheong, Te Pan,  \nSuresh Veeraperumal, ..., Karsoon Tan, Saiyi Zhong, Udayakumar Veerabagu  \nCorrespondence  \n[tankarsoon@bbgu.edu.cn](tankarsoon@bbgu.edu.cn) (K.T.),  \n[zhongsy@gdou.edu.cn](zhongsy@gdou.edu.cn) (S.Z.),  \nudayakumar.veerabagu@emu.ee (U.V.)  \nIn brief  \nBiomaterials; Biotechnology; Cell biology; Materials in biotechnology  \n• Hydrogels show strong antibacterial and antioxidant activity with low cytotoxicity  \n• Sustained Ag release, robust mechanics, high swelling; tailored for chronic wounds  \n• Hydrogels speed closure, boost collagen/angiogenesis, shift M2 macrophages  \nCheong et al., 2026, iScience 29, 114336  \nJanuary 16, 2026 © 2025 The Authors. Published by Elsevier Inc.  \n[https://doi.org/10.1016/j.isci.2025.114336](https://doi.org/10.1016/j.isci.2025.114336)  \nll  \niScience  \nll  \nOPEN ACCESS  \nArticle  \nMultifunctional carboxymethyl cellulose-based hydrogels with zwitterionic and silver nanowire components for wound management  \nKit-Leong Cheong,1,2 Te Pan,1 Suresh Veeraperumal,2 Franck Quero,3 Gowsika Jaikumar,4 Timo Kikas,5 Malairaj Sathuvan,6 Karsoon Tan,7,* Saiyi Zhong,1,* and Udayakumar Veerabagu3,5,8,*  \n1College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China  \n2Department of Biology, College of Science, Shantou University, Shantou, Guangdong, China  \n3Laboratorio de Nanocelulosay Biomateriales, Departamento de IngenieraQumica, Biotecnologay Materiales, Facultadde Ciencias Fsicasy Matem´aticas, Universidad de Chile, Santiago 8370456, Chile  \n4Department of Chemistry, Pachaiyappa’s College, University of Madras, Chennai 600030, India  \n5Chair of Biosystems Engineering, Institute of Forestry and Engineering, Estonian University of Life Sciences, Kreutzwaldi 56, 51014 Tartu, Estonia  \n6Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Kancheepuram, Tamil Nadu, India  \n7Guangxi Key Laboratory of Beibu Gulf Biodiversity Conservation, Beibu Gulf University, Qinzhou, Guangxi, China  \n8Lead contact  \n*Correspondence: [tankarsoon@bbgu.edu.cn](tankarsoon@bbgu.edu.cn) (K.T.), [zhongsy@gdou.edu.cn](zhongsy@gdou.edu.cn) (S.Z.), udayakumar.veerabagu@emu.ee (U.V.) [https://doi.org/10.1016/j.isci.2025.114336](https://doi.org/10.1016/j.isci.2025.114336)  \nSUMMARY  \nChronic wounds represent a major global health burden, while conventional dressings often fail to meet the complex requirements of chronic wound management, including infection control, moisture balance, and tissue regeneration. In this study, two multifunctional zwitterionic hydrogels—vinylpyridine carboxybetaine/ sulfobetaine/silver nanowire/carboxymethyl cellulose (VCS/Ag/CMC) and acrylamide carboxybetaine/sulfobetaine/silver nanowire/carboxymethyl cellulose (ACS/Ag/CMC)– were synthesized. Structural analyses confirmed the successful incorporation of aromatic or aliphatic zwitterionic components and uniform distribution of silver nanowires within the CMC-based hydrogel networks. Both hydrogels exhibited favorable mechanical strength, high swelling capacity, controlled degradability, and sustained silver release, providing a balanced profile for chronic wound applications. In vitro studies demonstrated potent antibacterial and antioxidant activities, while in vivo experiments revealed accelerated wound closure, enhanced re-epithelialization, collagen deposition, and neovascularization. Moreover, the hydrogels promoted macrophage polarization toward the pro-healing M2 phenotype. Collectively, these findings highlight the promise of zwitterionic hydrogels as multifunctional platforms for chronic wound management and regenerative medicine.  \nINTRODUCTION  \nFor centuries, wounds have posed a significant concern for patients, placing a heavy burden on healthcare providers and ea","cbCaieIIsR5vKJz6","https://ap.wps.com/l/cbCaieIIsR5vKJz6","pdf",14250431,22,"English","# Summary\n# Introduction\n# Results and Discussion\n## Antibacterial and antioxidant activity\n## In vivo wound closure and regeneration\n## Macrophage polarization and pro-healing response","[{\"question\":\"What hydrogels were synthesized for chronic wound management?\",\"answer\":\"Two multifunctional zwitterionic hydrogels were synthesized: VCS/Ag/CMC and ACS/Ag/CMC, both based on carboxymethyl cellulose and incorporating silver nanowires.\"},{\"question\":\"What key material characteristics support chronic wound application?\",\"answer\":\"The hydrogels show favorable mechanics, high swelling capacity, controlled degradability, and sustained silver release, with uniform nanowire distribution confirmed by structural analyses.\"},{\"question\":\"How do the hydrogels perform in biological studies?\",\"answer\":\"In vitro, they exhibit strong antibacterial and antioxidant activities; in vivo, they accelerate wound closure, enhance re-epithelialization, increase collagen deposition and neovascularization, and promote M2 macrophage polarization.\"}]","Multifunctional carboxymethyl cellulose-based hydrogels with zwitterionic and silver nanowire components for wound management | PDF",1790739936,55]