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Mokhtari2 ,\\#  Behdokht Jamali3   \nAmir Gholamzad4  Maliheh Entezari4, 5 ,∗  Mehrdad Hashemi4, 5 ,∗  Junjiang Fu1 ,∗  \n1 Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, China 2 Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran  \n3 Department of Microbiology and Genetic, Kherad Institute of Higher Education, Busheher, Iran  \n4 Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran  \n5 Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran  \n∗ Correspondence  \nJunjiang Fu, Key Laboratory of Epigenetics and Oncology, the Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China.  \nEmail: [fujunjiang@swmu.edu.cn](fujunjiang@swmu.edu.cn)  \nMerhrdad Hashemi, Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. [Email:](Email: drmehashemi@iautmu.ac.ir)[ drmehashemi@iautmu.ac.ir](Email: drmehashemi@iautmu.ac.ir)  \nMaliheh Entezari, Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. [Email:](Email: mentezari@iautmu.ac.ir)[ mentezari@iautmu.ac.ir](Email: mentezari@iautmu.ac.ir)  \nFunding information  \nNational Natural Science Foundation of China, Grant/Award Numbers: 82073263, 81672887; Research start-up fund by Foundation of Southwest Medical University, Grant/Award Number:  \n41/00170067  \nAbstract  \nThe TRIM (tripartite motif) family, with TRIM28 as a key member, plays a vital role in regulating health and disease. TRIM28 contains various functional domains essential for transcriptional regulation, primarily through its interaction with KRAB-ZNF proteins, which influence chromatin remodeling and gene expression. Despite extensive research, the precise mechanisms by which TRIM28 impacts health and disease remain elusive. This review delves into TRIM28’s multifaceted roles in maintaining health, contributing to a variety of diseases, and influencing cancer progression. In cancers, TRIM28 exhibits a dual nature, functioning as both a tumor promoter and suppressor depending on the cellular context and cancer type. The review also explores its critical involvement in processes such as DNA repair, cell cycle regulation, epithelialto-mesenchymal transition, and the maintenance of stem cell properties. By uncovering TRIM28’s complex roles across different cancers and other diseases, this review underscores its potential as a therapeutic target. The significance of TRIM28 as a versatile regulator opens the door to innovative therapeutic strategies, particularly in cancer treatment and the management of other diseases. Ongoing research into TRIM28 may yield key insights into disease progression and novel treatment options.  \nKEYWORDS  \ncancer pathogenesis, cancer therapy, DNA damage response, transcriptional regulation, TRIM family, TRIM28  \n\\#Mazaher Maghsoudloo and Khatere Mokhtari contributed equally to this work and share the first authorship.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s). MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd.  \nMedComm. 2024;5:e790 .  \n[https://doi.org/10.1002/mco2.790](https://doi.org/10.1002/mco2.790)  \n[wileyonlinelibrary.com/journal/mco2](wileyonlinelibrary.com/journal/mco2)  ","cbCaikYxzTrD6xxi","https://ap.wps.com/l/cbCaikYxzTrD6xxi","pdf",1405544,31,"English","# Introduction\n## TRIM family overview and domain motifs\n## TRIM proteins in disease and immune responses\n## TRIM28 roles in health and disease","[{\"question\":\"What domains enable TRIM28 to regulate transcription?\",\"answer\":\"TRIM28 contains functional domains that support transcriptional regulation, largely via interaction with KRAB-ZNF proteins and effects on chromatin remodeling and gene expression.\"},{\"question\":\"How can TRIM28 behave in cancer?\",\"answer\":\"TRIM28 shows a dual nature in cancers, acting as both a tumor promoter and a suppressor depending on cellular context and cancer type.\"},{\"question\":\"Which biological processes does TRIM28 influence according to the review?\",\"answer\":\"The review highlights involvement in DNA repair, cell cycle regulation, epithelial-to-mesenchymal transition (EMT), and maintenance of stem cell properties.\"}]","Multifaceted role of TRIM28 in health and disease | PDF",1790023653,78]