[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-422553-105":59,"doc-detail-422553-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","multidisciplinary-management-and-molecular-characterization-of-inferior-vena-cava-leiomyosarcoma-a-case-report","Multidisciplinary management and molecular characterization of inferior vena cava leiomyosarcoma - a case report","","Leiomyosarcoma of the inferior vena cava (IVC) is a rare, aggressive malignancy with poor prognosis and no universally accepted treatment protocol. The case describes a 69-year-old man whose IVC tumor extended from the common iliac veins to the right renal vein. Imaging suggested IVC involvement; histopathology confirmed leiomyosarcoma. Multidisciplinary surgery excised the tumor en bloc with the IVC and right kidney after four cycles of doxorubicin. Next-generation sequencing identified TP53, RB1, KMT2C, and TSC2 mutations. Local recurrence occurred four months later, treated with chemotherapy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multidisciplinary-management-and-molecular-characterization-of-inferior-vena-cava-leiomyosarcoma-a-case-report/422553/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multidisciplinary-management-and-molecular-characterization-of-inferior-vena-cava-leiomyosarcoma-a-case-report/422553.png","ImageObject",300,407,{"name":92,"@type":93},"awa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",17,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main clinical presentation and imaging finding in the reported IVC leiomyosarcoma case?","Question",{"text":113,"@type":114},"A 69-year-old man presented with right-sided abdominal pain. Ultrasound and CT showed a retroperitoneal mass displacing the pancreas and right kidney, with suspected IVC and right renal vessel involvement.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the diagnosis confirmed and what treatments were provided initially?",{"text":118,"@type":114},"Histopathological examination confirmed leiomyosarcoma. The patient received four chemotherapy cycles with doxorubicin before undergoing surgical resection.",{"name":120,"@type":111,"acceptedAnswer":121},"What did molecular profiling reveal and how did the patient’s course progress after surgery?",{"text":122,"@type":114},"Next-generation sequencing identified mutations in TP53, RB1, KMT2C, TSC2, and other genes. The patient experienced local recurrence at four months and was treated with chemotherapy.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},422553,1790740468,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},3985747858093,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Pini et al. World Journal of Surgical Oncology (2026) 24:7  \n[https://doi.org/10.1186/s12957-025-04112-6](https://doi.org/10.1186/s12957-025-04112-6)  \nWorld Journal of Surgical Oncology  \nCASE REPORT Open Access  \nMultidisciplinary management and molecular characterization of inferior vena cava leiomyosarcoma: a case report  \nAlessia Pini 1,2*, Maria Abbondanza Pantaleo2,3, Annalisa Astolfi2,4, Stefano Ancetti 1, Martina Sofia Rossi5, Maria Giulia Pirini6, Livia Gozzellino2, Alice Costa4, Maria Concetta Nigro2,3, Luca Boschi7, Riccardo Schiavina2,5, Gilberto Poggioli2,7 and Mauro Gargiulo 1,2  \nAbstract  \nLeiomyosarcoma of the inferior vena cava (IVC) is a rare and aggressive malignancy, with poor prognosis and no universally accepted treatment protocol. We present the case of a 69-year-old male with an IVC leiomyosarcoma, which extended from the common iliac veins to the right renal vein. Initial imaging showed a retroperitoneal mass with suspected IVC involvement. Histopathological examination confirmed leiomyosarcoma, and the patient underwent four chemotherapy cycles with doxorubicin, followed by surgical resection. A multidisciplinary approach, including general, vascular, and urologic surgeons, was employed. The tumor was excised en bloc with the IVC and right kidney. No prosthetic IVC reconstruction was necessary due to the lack of hemodynamic changes after clamping. Postoperative recovery was uneventful except for mild renal impairment. Molecular profiling of the tumor using next-generation sequencing (NGS) identified mutations in TP53, RB1, KMT2C, TSC2, and other genes associated with chromatin stability and tumor suppression. The patient experienced a local recurrence at four months and was treated with chemotherapy. This case underscores the importance of personalized treatment strategies, including surgical decision-making, chemotherapy, and molecular characterization, in managing rare tumors like IVC leiomyosarcoma. Further research is needed to explore potential oncogenic targets and improve prognosis.  \nKeywords Leiomyosarcoma, Inferior vena cava, Surgery, Chemotherapy, Molecular profiling, Next-generation sequencing  \n*Correspondence:  \nAlessia Pini  \n[alessia.pini3@unibo.it](alessia.pini3@unibo.it)  \n1Vascular Surgery Unit, IRCCS Azienda Ospedal iero Universitaria di Bologna, Bologna, Italy  \n2Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Via Massarenti 9, 40137, Bologna, Italy  \n3Oncology Unit, IRCCS Azienda Ospedal iero Universitaria di Bologna, Bologna, Italy  \n4IRCCS Azienda Ospedal iero-Universitaria di Bologna, Bologna, Italy 5Urology Unit, IRCCS Azienda Ospedal iero Universitaria di Bologna, Bologna, Italy  \n6Pathology Unit, IRCCS Azienda Ospedal iero Universitaria di Bologna, Bologna, Italy  \n7General Surgery Unit, IRCCS Azienda Ospedal iero Universitaria di Bologna, Bologna, Italy  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nPini et al. World Journal ","cbCaiumSnvUlx4kS","https://ap.wps.com/l/cbCaiumSnvUlx4kS","pdf",1193217,"English","# Abstract\n# Introduction\n# Detailed case description","[{\"question\":\"What was the main clinical presentation and imaging finding in the reported IVC leiomyosarcoma case?\",\"answer\":\"A 69-year-old man presented with right-sided abdominal pain. Ultrasound and CT showed a retroperitoneal mass displacing the pancreas and right kidney, with suspected IVC and right renal vessel involvement.\"},{\"question\":\"How was the diagnosis confirmed and what treatments were provided initially?\",\"answer\":\"Histopathological examination confirmed leiomyosarcoma. The patient received four chemotherapy cycles with doxorubicin before undergoing surgical resection.\"},{\"question\":\"What did molecular profiling reveal and how did the patient’s course progress after surgery?\",\"answer\":\"Next-generation sequencing identified mutations in TP53, RB1, KMT2C, TSC2, and other genes. The patient experienced local recurrence at four months and was treated with chemotherapy.\"}]","Multidisciplinary management and molecular characterization of inferior vena cava leiomyosarcoma - a case report | PDF",1790627928,15]