[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-352888-en":59,"doc-seo-352888-105":81},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":72,"language":73,"language_code":74,"site_id":75,"html_lang":74,"table_of_contents":76,"faqs":77,"seo_title":78,"seo_description":66,"update_tm":79,"read_time":80},352888,962085570644,"Melati","https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Multidimensional Regulatory Network of YAP1 Driving Malignant Progression in Esophageal Cancer - A Review - Review","Esophageal cancer (EC) is among the most lethal gastrointestinal malignancies, with poor outcomes driven by limited early diagnosis, molecular heterogeneity, and therapeutic resistance. As a key effector of the Hippo signaling pathway, Yes-associated protein 1 (YAP1) is increasingly implicated. This review systematically summarizes multi-omics findings, molecular mechanisms, and preclinical or translational evidence for YAP1. It details Hippo-dependent and independent activation, links environmental risk cross-regulation, and connects YAP1 to malignant phenotypes including proliferation, apoptosis, EMT, and metastasis. It evaluates YAP1 as diagnostic, prognostic, and predictive biomarkers, and summarizes roles in chemotherapy, radiotherapy, and immune tolerance, including targeted therapy advances. Targeting YAP1 is promising yet challenged by functional duality, subtype heterogeneity, and complex resistance mechanisms. Future work should develop highly selective inhibitors, integrate multi-omics technologies, and advance clinical translation to guide precision treatment.","Tech Science Press  \n| [https://doi. org/10.32604/or.2026.073484](https://doi. org/10.32604/or.2026.073484)\u003Cbr>REVIEW |  |\n| --- | --- |\n|  | |\n| Multidimensional Regulatory Network of YAP1 Driving Malignant Progression in Esophageal Cancer: Molecular Mechanisms and Targeted Therapy: A Review\u003Cbr>Jun-Hui Chen1, Si-Run Du1, Chang Liu1, Bei-Bei Liu1, Hai-Ying Xu2, Xin-Ying Ji2, Bo Feng3, Chun-Zheng Ma3 and Jun-Hui Guo3, *\u003Cbr>1 The Second School of Clinical Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, China\u003Cbr>2 Henan Provincial Research Center of Engineering Technology for Nuclear Protein Medical Detection, Zhengzhou Health College, Zhengzhou, China\u003Cbr>3 Department of Oncology, The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China *Corresponding Author: [Jun-Hui Guo. Email: gjunhui2008@163.com](Jun-Hui Guo. Email: gjunhui2008@163.com)\u003Cbr>[Received: 19 September 2025](Received: 19 September 2025); [Accepted: 20 January 2026](Accepted: 20 January 2026); [Published: 22 April 2026](Published: 22 April 2026)\u003Cbr>ABSTRACT: Esophageal cancer (EC) ranks among the most lethal gastrointestinal malignancies. Due to challenges in early diagnosis, molecular heterogeneity, and therapeutic resistance, patient prognosis remains extremely poor, necessitating the development of novel biomarkers and therapeutic targets. As a core effector of the Hippo signaling pathway, the potential significance of Yes-associated protein 1 ( YAP1) has garnered increasing attention. This paper aims to systematically summarize the multi-omics research, molecular mechanisms, and preclinical/translational evidence for YAP1, covering its activation pathways, biological functions, clinical significance, and therapeutic strategies. We elucidated YAP1’s multidimensional regulatory network in EC, including Hippo-dependent and-independent mechanisms, cross-regulation with environmental risk factors, and its role in malignant phenotypes such as cell proliferation, apoptosis, epithelial-mesenchymal transition (EMT), and metastasis. The potential of YAP1 as a diagnostic, prognostic, and predictive biomarker is evaluated, alongside summarizing its role in mediating chemotherapy, radiotherapy, and immune tolerance mechanisms, along with recent advances in targeted therapies. This provides a theoretical foundation for subsequent basic research and precision medicine translation. As a potential hub in the EC signaling network, it is considered to play a key role in driving tumor progression and treatment resistance through multiple pathways Targeting YAP1 holds broad clinical promise but faces challenges including functional duality, subtype heterogeneity, and complex resistance mechanisms. Future efforts should focus on developing highly selective inhibitors, integrating multi-omics technologies and innovative models to advance clinical translation and provide new strategies for precision treatment of EC patients.\u003Cbr>KEYWORDS: Yes-associated protein 1; esophageal cancer; Hippo signaling pathway; molecular mechanisms; prognosis; targeted therapy |  |\n\n1 Introduction  \nAccording to the latest global cancer statistics, esophageal cancer (EC)is a highly prevalent gastrointestinal malignant tumor worldwide, with the eleventh highest incidence rate and the seventh highest mortality rate [1]. Despite significant advances in diagnostic and therapeutic techniques, the 5-year survival rate of EC patients is still less than 20%, and the treatment of EC faces multiple challenges; thus, there is an urgent need to explore new therapeutic targets and strategies.  \nCopyright © 2026 The Authors. Published by Tech Science Press. This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nIn recent years, Yes-associated protein 1 ( YAP1)has emerged playing a pivotal role as a co","cbCaisjYmkX9TpFv","https://ap.wps.com/l/cbCaisjYmkX9TpFv","pdf",54407229,31,"English","en",105,"# Introduction\n## Background on esophageal cancer and treatment challenges\n## Rationale for focusing on YAP1 and the Hippo signaling pathway\n## Gap in existing literature and objectives of the review\n## Proposed trinity-based multidimensional regulatory network framework","[{\"question\":\"Why is targeting YAP1 considered important in esophageal cancer?\",\"answer\":\"YAP1 acts as a core effector of the Hippo signaling pathway, and its aberrant activation is linked to malignant progression in EC, including proliferation, metastasis, and survival-related processes.\"},{\"question\":\"What dimensions does the review use to address limitations in previous research?\",\"answer\":\"It proposes a trinity-based multidimensional framework covering carcinogenic mechanisms, clinical significance, and targeted therapy, integrating environmental carcinogens, pathway crosstalk, and evidence from basic to clinical translation.\"},{\"question\":\"What are the main clinical and translational challenges for YAP1-targeted therapy?\",\"answer\":\"The review highlights functional duality, subtype heterogeneity, and complex resistance mechanisms as major obstacles that must be addressed for effective translation.\"}]","Multidimensional Regulatory Network of YAP1 Driving Malignant Progression in Esophageal Cancer - A Review - Review | PDF",1790101898,78,{"code":4,"msg":82,"data":83},"ok",{"site_id":75,"language":74,"slug":84,"title":65,"keywords":85,"description":66,"schema_data":86,"social_meta":140,"head_meta":142,"extra_data":144,"updated_unix":145},"multidimensional-regulatory-network-of-yap1-driving-malignant-progression-in-esophageal-cancer-a-review-review","",{"@graph":87,"@context":139},[88,102,122],{"@type":89,"itemListElement":90},"BreadcrumbList",[91,95,97,100],{"item":92,"name":93,"@type":94,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":96,"name":9,"@type":94,"position":14},"https://docshare.wps.com/document/",{"item":98,"name":40,"@type":94,"position":99},"https://docshare.wps.com/document/research-report/",3,{"item":101,"name":65,"@type":94,"position":19},"https://docshare.wps.com/document/multidimensional-regulatory-network-of-yap1-driving-malignant-progression-in-esophageal-cancer-a-review-review/352888/",{"url":101,"name":65,"@type":103,"image":104,"author":109,"headline":65,"publisher":111,"fileFormat":114,"inLanguage":74,"description":66,"dateModified":115,"datePublished":116,"encodingFormat":114,"isAccessibleForFree":117,"interactionStatistic":118},"DigitalDocument",{"url":105,"@type":106,"width":107,"height":108},"https://docshare.wps.com/thumbnails/multidimensional-regulatory-network-of-yap1-driving-malignant-progression-in-esophageal-cancer-a-review-review/352888.png","ImageObject",300,407,{"name":63,"@type":110},"Person",{"url":92,"name":112,"@type":113},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":119,"interactionType":120,"userInteractionCount":8},"InteractionCounter",{"@type":121},"ViewAction",{"@type":123,"mainEntity":124},"FAQPage",[125,131,135],{"name":126,"@type":127,"acceptedAnswer":128},"Why is targeting YAP1 considered important in esophageal cancer?","Question",{"text":129,"@type":130},"YAP1 acts as a core effector of the Hippo signaling pathway, and its aberrant activation is linked to malignant progression in EC, including proliferation, metastasis, and survival-related processes.","Answer",{"name":132,"@type":127,"acceptedAnswer":133},"What dimensions does the review use to address limitations in previous research?",{"text":134,"@type":130},"It proposes a trinity-based multidimensional framework covering carcinogenic mechanisms, clinical significance, and targeted therapy, integrating environmental carcinogens, pathway crosstalk, and evidence from basic to clinical translation.",{"name":136,"@type":127,"acceptedAnswer":137},"What are the main clinical and translational challenges for YAP1-targeted therapy?",{"text":138,"@type":130},"The review highlights functional duality, subtype heterogeneity, and complex resistance mechanisms as major obstacles that must be addressed for effective translation.","https://schema.org",{"og:url":101,"og:type":141,"og:title":65,"og:site_name":112,"og:description":66},"article",{"robots":143,"canonical":101},"index,follow",{"doc_id":61,"site_id":75},1790177022]