[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327489-105":59,"doc-detail-327489-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","multidimensional-data-analysis-revealed-thyroiditis-associated-tcf19-snp-rs2073724-as-a-highly-ranked-protective-variant-in-thyroid-cancer","Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer","","Thyroid cancer is the most prevalent malignant endocrine tumor, and rising incidence plus frequent dedifferentiation and metastasis drive high mortality. To support aggressive disease management, the study investigates TCF19, a transcription factor linked to malignant phenotypes, while its role in thyroid neoplasms is unclear. Genome-wide and phenome-wide association analyses identify TCF19 rs2073724 as a causal protective biomarker and reveal strong links to autoimmune thyroiditis and hypothyroidism. Functional experiments show TCF19 regulates inflammatory and immune processes and the C>T variant disrupts protein-DNA binding and target-gene expression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multidimensional-data-analysis-revealed-thyroiditis-associated-tcf19-snp-rs2073724-as-a-highly-ranked-protective-variant-in-thyroid-cancer/327489/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multidimensional-data-analysis-revealed-thyroiditis-associated-tcf19-snp-rs2073724-as-a-highly-ranked-protective-variant-in-thyroid-cancer/327489.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main genetic finding of this study regarding TCF19 in thyroid cancer?","Question",{"text":112,"@type":113},"The study identifies rs2073724 as a causal biomarker with protective effects, linked to thyroid function and hypothyroidism as well as autoimmunity.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the authors connect TCF19 to disease risk across many phenotypes?",{"text":117,"@type":113},"They used genome-wide and phenome-wide association studies to reveal significant associations between TCF19 and autoimmune diseases and human cancers.",{"name":119,"@type":110,"acceptedAnswer":120},"What functional mechanism did the study propose for the rs2073724 variant?",{"text":121,"@type":113},"The C>T variant disrupted TCF19 protein binding to target gene promoters, altering target-gene expression and reversing the downstream effect of TCF19.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327489,1789996235,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","[www.aging-us.com](www.aging-us.com) AGING 2024, Vol. 16, No. 7  \nResearch Paper  \nMultidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer  \nXianhui Ruan1,*, Yu Liu1,*, Shuping Wu1,2, Guiming Fu1,3, Mei Tao1, Yue Huang1, Dapeng Li1, Songfeng Wei1, Ming Gao1,4,5, Shicheng Guo6, Junya Ning1,4, Xiangqian Zheng1  \n1 Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China  \n2 Department of Head and Neck Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou 350014, Fujian, China  \n3Thyroid-Otolaryngology Department, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610000, Sichuan, China  \n4 Department of Thyroid and Breast Surgery, Tianjin Union Medical Center, Tianjin 300121, China  \n5Tianjin Key Laboratory of General Surgery in Construction, Tianjin Union Medical Center, Tianjin 300121, China 6 Department of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA  \n*Equal contribution  \nCorrespondence to: Shicheng Guo, Junya Ning, Xiangqian Zheng; email: [shihcheng.guo@gmail.com](shihcheng.guo@gmail.com), [https://orcid.org/0000-](https://orcid.org/0000-)[ ](https://orcid.org/0000-)0002-7047-9972; [ningjunya123@tmu.edu.cn](ningjunya123@tmu.edu.cn); [xzheng05@tmu.edu.cn](xzheng05@tmu.edu.cn)  \n[Keywords:](Keywords: thyroid cancer)[ thyroid cancer](Keywords: thyroid cancer), GWAS, biomarker, therapeutic target, SNP  \nReceived: November 24, 2023 Accepted: March 14, 2024 Published: April 4, 2024  \nCopyright: © 2024 Ruan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  \nABSTRACT  \nBackground: Thyroid cancer represents the most prevalent malignant endocrine tumour, with rising incidence worldwide and high mortality rates among patients exhibiting dedifferentiation and metastasis. Effective biomarkers and therapeutic interventions are warranted in aggressive thyroid malignancies. The transcription factor 19 (TCF19) gene has been implicated in conferring a malignant phenotype in cancers. However, its contribution to thyroid neoplasms remains unclear.  \nResults: In this study, we performed genome-wide and phenome-wide association studies to identify a potential causal relationship between TCF19 and thyroid cancer. Our analyses revealed significant associations between TCF19 and various autoimmune diseases and human cancers, including cervical cancer and autoimmune thyroiditis, with a particularly robust signal for the deleterious missense variation rs2073724 that is associated with thyroid function, hypothyroidism, and autoimmunity. Furthermore, functional assays and transcriptional profiling in thyroid cancer cells demonstrated that TCF19 regulates important biological processes, especially inflammatory and immune responses. We demonstrated that TCF19 could promote the progression of thyroid cancer in vitro and in vivo and the C>T variant of rs2073724 disrupted TCF19 protein binding to target gene promoters and their expression, thus reversing the effect of TCF19 protein.  \nConclusions: Taken together, these findings implicate TCF19 as a promising therapeutic target in aggressive thyroid malignancies and designate rs2073724 as a causal biomarker warranting further investigation in thyroid cancer.  \n6488  \nINTRODUCTION  \nThyroid cancer is the most common malignant endocrine tumour, accounting for 1-2% of all ","cbCaiddyvBsX6JeA","https://ap.wps.com/l/cbCaiddyvBsX6JeA","pdf",4859892,22,"English","# Abstract\n## Background\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What is the main genetic finding of this study regarding TCF19 in thyroid cancer?\",\"answer\":\"The study identifies rs2073724 as a causal biomarker with protective effects, linked to thyroid function and hypothyroidism as well as autoimmunity.\"},{\"question\":\"How did the authors connect TCF19 to disease risk across many phenotypes?\",\"answer\":\"They used genome-wide and phenome-wide association studies to reveal significant associations between TCF19 and autoimmune diseases and human cancers.\"},{\"question\":\"What functional mechanism did the study propose for the rs2073724 variant?\",\"answer\":\"The C\\u003eT variant disrupted TCF19 protein binding to target gene promoters, altering target-gene expression and reversing the downstream effect of TCF19.\"}]","Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer | PDF",1789977320,55]