[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443633-105":59,"doc-detail-443633-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","multi-talented-myeloid-cells-editorial","Multi-talented myeloid cells - Editorial","","The editorial outlines how myeloid cells—monocytes, macrophages, dendritic cells, and granulocytes—serve as evolutionarily ancient defenders and regulators beyond pathogen elimination. It highlights a research shift showing their roles in homeostasis, tissue repair, and metabolism, with dysfunction contributing to immune-mediated, fibrotic, and degenerative disease. Obesity is emphasized as a key healthcare challenge, with evidence that obesity reshapes dendritic cell biology and metabolic fitness, impairing antiviral immunity. It also discusses eosinophils in metabolic health and fibrosis, underscoring complex immune-metabolic integration.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multi-talented-myeloid-cells-editorial/443633/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multi-talented-myeloid-cells-editorial/443633.png","ImageObject",300,407,{"name":92,"@type":93},"Jake","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What main roles do myeloid cells play beyond pathogen elimination?","Question",{"text":113,"@type":114},"They regulate homeostasis, tissue repair, and metabolism, and they can drive disease when dysregulated.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does obesity alter dendritic cell biology in this editorial?",{"text":118,"@type":114},"Obesity constrains dendritic cell metabolic capacity, reducing protein synthesis and impairing interferon and IL-6 production and antiviral gene expression despite intact NF-κB activation.",{"name":120,"@type":111,"acceptedAnswer":121},"What are the described functions of eosinophils in metabolic health and disease?",{"text":122,"@type":114},"Eosinophils regulate adipose tissue homeostasis, promoting white-to-beige adipocyte conversion and limiting weight gain, but their cytokines can also worsen fibrosis, especially in the liver.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},443633,1790862941,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":52,"preview_page_count":4},962084928904,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Editorial  \nMulti-talented myeloid cells  \nSam Bankole1,*, Lai Guan Ng2 and Florent Ginhoux3  \n1University of Edinburgh, The Institute of Regeneration and Repair, Edinburgh, Scotland, UK2Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore3Paris-Saclay University, Gustave Roussy, INSERM U1015, Villejuif, France  \n*Corresponding author. Sam Bankole, University of Edinburgh, The Institute of Regeneration and Repair, 4-5 Little France Dr, Edinburgh, Scotland EH16 4UU, UK.E-mail: s.t.bankole@sms.ed.ac.uk  \nAbbreviations: APC: Antigen-presenting cell; DC: Dendritic Cell; FcϵRI: High-affinity IgE receptor; GM-CSF: Granulocyte-macrophage colony-stimulating factor;MHCII: Major histocompatibility complex class II; NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells; NKT cell: Natural killer T cells;Th1/Th2: T helper type1/type 2 cells; TNFα: Tumour necrosis factor alpha; Treg: Regulatory T cell; γδ T cell: Gamma delta T cells.  \nMyeloid cells, including monocytes, macrophages, dendriticcells (DCs), and granulocytes (basophils, eosinophils, mastcells, and neutrophils), are our evolutionarily ancient protec -tors. With the exception of DCs, these innate immune cellsare found across all vertebrates even those without adaptiveimmunity. They form the first line of defence against patho -gens through mechanisms including phagocytosis and produc -tion of toxic molecules such as reactive oxygen species.Granulocytes such as basophils, eosinophils, and mast cellshave further strategies to combat parasitic infection, a chal -lenge now far less common in industrialized societies.  \nThrough the twentieth century, infectious and parasiticdiseases declined with the advent of sterilization techniques,vaccines, and antimicrobials, while immune-mediated disor -ders such as autoimmunity and allergy became increasinglyprevalent [1–3] . In parallel, landmark discoveries in the1950s—including autoantibodies and the recognition ofautoimmunity—drew attention towards the adaptive im -mune system, with innate cells often regarded as compara -tively rudimentary [4] . At the same time, dramatic rises inobesity and its complications reflected the transition to sed -entary, hypercaloric lifestyles. In this context, interest inmyeloid biology waned—partly due to limited tools forstudying these cells compared with approaches availablefor T and B lymphocytes—and was further overshadowedby an intense focus on adaptive responses.  \nOver the past couple of decades this perspective has shifted.A renaissance in myeloid cell research underscores the extraor -dinary versatility and immunological relevance of these cells[4] . Beyond their classical functions in pathogen elimination,inflammation, and antigen presentation, myeloid cells arenow recognized as critical regulators of homeostasis, tissue re -pair, and metabolism, playing important roles in physiology[5]. When dysregulated, they fuel immune-mediated, fibrotic,and degenerative disease. Heterogeneity and plasticity arenow recognized as defining features of myeloid cells, reflectingtheir functional capacity and context-specific roles. This  \nspecial issue highlights some of the unconventional aspectsof myeloid cell biology, showing how these ancient cells re -main at the heart of health and disease in modern society.  \nArguably, obesity is one of the most important healthcarechallenges in high income settings due to its link with in -creased chronic disease, including diabetes, cardiovasculardisease and cancer. Obesity is also associated with poor infec -tion and vaccine responses, yet the underlying mechanisms re -main unclear. In this issue, the article by Andrea Woodcockand colleagues shed light on this question by examininghow obesity alters DC biology. Using GM-CSF-dependentDCs, they show that antiviral cytokine responses depend onglycolysis to sustain protein translation [6]. When generatedfrom mice fed on a high-fat diet, DCs displayed reduced pro -tein","cbCaifQE1EfBBHE3","https://ap.wps.com/l/cbCaifQE1EfBBHE3","pdf",385146,"English","# Editorial\n## Myeloid cell versatility and immune roles\n## Obesity impact on dendritic cell metabolism and antiviral immunity\n## Immune-metabolic integration and broader implications\n## Eosinophils in metabolic health and fibrosis","[{\"question\":\"What main roles do myeloid cells play beyond pathogen elimination?\",\"answer\":\"They regulate homeostasis, tissue repair, and metabolism, and they can drive disease when dysregulated.\"},{\"question\":\"How does obesity alter dendritic cell biology in this editorial?\",\"answer\":\"Obesity constrains dendritic cell metabolic capacity, reducing protein synthesis and impairing interferon and IL-6 production and antiviral gene expression despite intact NF-κB activation.\"},{\"question\":\"What are the described functions of eosinophils in metabolic health and disease?\",\"answer\":\"Eosinophils regulate adipose tissue homeostasis, promoting white-to-beige adipocyte conversion and limiting weight gain, but their cytokines can also worsen fibrosis, especially in the liver.\"}]","Multi-talented myeloid cells - Editorial | PDF",1790704707]