[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332208-105":59,"doc-detail-332208-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","multi-omics-and-single-cell-characterization-of-cancer-immunosenescence-landscape","Multi-omics and single cell characterization of cancer immunosenescence landscape","","Cellular senescence (CS) is tightly linked to tumor progression, yet cancer-wide CS gene relationships with telomere length and the single-cell evolutionary dynamics of malignant and immune cells at the CS level remain insufficiently defined. This work defines a CS-associated “senescence signature,” showing higher scores predict worse patient prognosis and correlate with older age, genomic instability, longer telomeres, and specific immune infiltration patterns. Single-cell results reveal shared evolutionary trends across cell types. MAPK and apoptosis-related processes are implicated, and the signature supports survival prediction, a web portal, and drug sensitivity estimates for MEK/ERK and BCL-2 family inhibitors, informing immune checkpoint inhibitor response.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/multi-omics-and-single-cell-characterization-of-cancer-immunosenescence-landscape/332208/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/multi-omics-and-single-cell-characterization-of-cancer-immunosenescence-landscape/332208.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the “senescence signature” and what does it indicate?","Question",{"text":113,"@type":114},"The study defines a CS-associated “senescence signature.” Patients with higher signature values show worse prognosis and stronger associations with telomere-related and immune infiltration features.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do telomere length and immune infiltration relate to the signature?",{"text":118,"@type":114},"Higher senescence signature correlates with longer telomeres and increased lymphocytic infiltration, including pro-tumor immune components such as Treg cells and MDSCs.",{"name":120,"@type":111,"acceptedAnswer":121},"What single-cell findings support the role of CS in immune-cancer evolution?",{"text":122,"@type":114},"Single-cell analysis shows malignant and immune cells follow a consistent evolutionary trend at the CS level, with MAPK signaling and apoptotic processes suggested as key contributors.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332208,1790170732,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":36,"preview_page_count":4},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","[www. nature.com/scientificdata](www. nature.com/scientificdata)  \nOPEn  \nAnALYSiS  \nMulti-omics and single cell characterization of cancer immunosenescence landscape  \nQiuxia Wei1,13, Ruizhi Chen1,2,3,13, Xue He4,13, Yanan Qu5,13, ChangjianYan6, Xiaoni Liu7, Jing Liu2, Jiahao Luo2, ZiningYu8, Wenping Hu2, Liqun Wang9, Xiaoya Lin2, Chaoling Wu10, Jinyuan Xiao2, Haibo Zhou11, Jing Wang1, Mingxia Zhu1, PingYang1, Yingtong Chen1, Qilong tan12, XiaoliangYuan7 ✉, HongmeiJing1 ✉ & Weilong Zhang1 ✉  \nCellular senescence (CS) is closely related to tumor progression. However, the studies about CS genes across human cancers have not explored the relationship between cancer senescence signature and telomere length. Additionally, single-cell analyses have not revealed the evolutionary trends of malignant cells and immune cells atthe CS level. We defined a CS-associated signature, called“senescence signature”, and found that patients with higher senescence signature had worse prognosis. Higher senescence signature was related to older age, higher genomic instability, longer telomeres, increased lymphocytic infiltration, higher pro-tumor immune infiltrates (Treg cells and MDSCs), and could predict responses to immune checkpoint inhibitor therapy. Single-cell analysis further reveals malignant cells and immune cells share a consistent evolutionary trend atthe CS level. MAPK signaling pathway and apoptotic processes may play a key role inCS, and senescence signature may effectively predict sensitivity of MEK1/2 inhibitors, ERK1/2 inhibitors and BCL-2 family inhibitors. We also developed a new CS prediction model of cancer survival and established a portal website to apply this model ([https://bio-pub.shinyapps.io/cs_nomo/](https://bio-pub.shinyapps.io/cs_nomo/)).  \nIntroduction  \nAging is one of the important causes of cancer, with epidemiological investigations indicating that the cancer incidence increases with age1. Cellular senescence (CS) contributes to aging in humans2. CS is considered to be a state of cell proliferation arrest due to the cell cycle being halted3. Both cancer and CS result from the time-dependent accumulation of cellular damage, and many studies have shown a substantial overlap between the hallmarks of CS and cancer4. These hallmarks include epigenetic changes, altered signaling pathways, chromosomal instability, changes in protein homeostasis, damage to telomeres, mitochondrial dysfunction, and more4,5. In particular, the discovery of the senescence-associated secretory phenotype (SASP)6 suggests that senescent cells can promote tumor progression and metastasis by influencing the tumor microenvironment (TME)7.  \nAntitumor acquired immune programs can be tampered with by factors secreted by senescent cells in the TME, which regulate the malignant behavior of tumor by adjusting the components and functions of the innate  \n1Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, 100191, China.  \n2Gannan Medical University, Ganzhou, 341000, China. 3Suichang County People’s Hospital, Lishui, 323000, China.  \n4 Department of Pathology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. 5 Peking University Research Center on Aging, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, 100191, Beijing, China. 6The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, China. 7Department of Respiratory Medicine, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China. 8 Department of Clinical Laboratory, Shangrao Municipal Hospital, Jiangxi, 334000, China. 9Department of Radiation Oncology, Harbin Medical University cancer Hospital, Harbin, 150000, China. 10 Department of Respiratory medicine, Affiliated Hospital of Jiujiang University, Jiujiang, 332000, China. 11 Department of Epidemiology & Health Statistics, School of Public Health, School of ","cbCaiq8XOeE2ylY1","https://ap.wps.com/l/cbCaiq8XOeE2ylY1","pdf",5091974,16,"English","# Introduction\n## Aging and cellular senescence in cancer\n## Senescence-associated secretory phenotype (SASP) and tumor microenvironment\n## Impact on immune therapy response and targeted therapy gaps","[{\"question\":\"What is the “senescence signature” and what does it indicate?\",\"answer\":\"The study defines a CS-associated “senescence signature.” Patients with higher signature values show worse prognosis and stronger associations with telomere-related and immune infiltration features.\"},{\"question\":\"How do telomere length and immune infiltration relate to the signature?\",\"answer\":\"Higher senescence signature correlates with longer telomeres and increased lymphocytic infiltration, including pro-tumor immune components such as Treg cells and MDSCs.\"},{\"question\":\"What single-cell findings support the role of CS in immune-cancer evolution?\",\"answer\":\"Single-cell analysis shows malignant and immune cells follow a consistent evolutionary trend at the CS level, with MAPK signaling and apoptotic processes suggested as key contributors.\"}]","Multi-omics and single cell characterization of cancer immunosenescence landscape | PDF",1789997324]