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Their role in solid tumor surveillance remains unclear, and knowledge in blood cancers is limited. This review summarizes MAIT biology in hematological neoplasms across diagnosis and treatment, discusses strategies to target MAIT cells as therapeutic tools, and highlights key unresolved questions and limitations for future MAIT-based therapies in hematological malignancies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mucosal-associated-invariant-t-cells-in-hematological-malignancies-current-knowledge-pending-questions/377708/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mucosal-associated-invariant-t-cells-in-hematological-malignancies-current-knowledge-pending-questions/377708.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are mucosal-associated invariant T cells (MAIT) and why are they important?","Question",{"text":112,"@type":113},"MAIT cells are MR1-restricted, innate-like T cells that recognize bacterial/fungal metabolites and can produce type 1 cytokines and cytotoxic molecules. Their antimicrobial functions and innate-like behavior make them relevant to tumor immunology.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is known about MAIT cells in hematological malignancies?",{"text":117,"@type":113},"Fewer studies focus on blood cancers compared with solid tumors. The review describes observations such as reduced circulating MAIT cells in newly diagnosed multiple myeloma and explores how MAIT cells behave in hematological disease.",{"name":119,"@type":110,"acceptedAnswer":120},"Which therapeutic strategies are discussed for targeting MAIT cells?",{"text":121,"@type":113},"The review outlines potential approaches to manipulate MAIT cells, including CAR-MAIT, and considers how MAIT cells may respond to other treatments such as checkpoint blockade.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377708,1790536632,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","TYPE Review  \nPUBLISHED 20 March 2023  \nDOI 10.3389/fimmu.2023.1160943  \nOPEN ACCESS  \nEDITED BY  \nPaolo Dellabona,  \nSan Raffaele Scientific Institute (IRCCS), Italy  \nREVIEWED BY  \nLauren J. Howson,  \nThe University of Melbourne, Australia Tonya J. Webb,  \nUniversity of Maryland, United States  \n*CORRESPONDENCE  \nEmmanuel Treiner  \n [Emmanuel.treiner@inserm.fr](Emmanuel.treiner@inserm.fr)  \nSPECIALTY SECTION  \nThis article was submitted to T Cell Biology,  \na section of the journal Frontiers in Immunology  \nRECEIVED 07 February 2023  \nACCEPTED 06 March 2023  \nPUBLISHED 20 March 2023  \nCITATION  \nTreiner E (2023) Mucosal-associated invariant T cells in hematological malignancies: Current knowledge, pending questions.  \nFront. Immunol. 14:1160943 .  \ndoi: 10.3389/fimmu.2023.1160943  \nCOPYRIGHT  \n© 2023 Treiner. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nMucosal-associated invariant T cells in hematological malignancies: Current knowledge, pending questions  \nEmmanuel Treiner 1,2,3*  \n1 Infinity, Inserm UMR1291, Toulouse, France, 2 University Toulouse 3, Toulouse, France, 3 Laboratory of Immunology, Toulouse University Hospital, Toulouse, France  \nNon-classical HLA restricted T cell subsets such as gd T and NK-T cells are showing promises for immune-based therapy of hematological malignancies. Mucosal-Associated Invariant T cells (MAIT) belong to this family of innate-like T cell subsets and are the focus of many studies on infectious diseases, owing to their unusual recognition of bacterial/fungal metabolites. Their ability to produce type 1 cytokines (IFNg, TNFa) as well as cytotoxic effector molecules endows them with potential anti-tumor functions. However, their contribution to tumor surveillance in solid cancers is unclear, and only few studies have specifically focused on MAIT cells in blood cancers. In this review, we wish to recapitulate our current knowledge on MAIT cells biology in hematological neoplasms, at diagnosis and/or during treatment, as well as tentative approaches to target them as therapeutic tools. We also wish to take this opportunity to briefly elaborate on what we think are important question to address in this field, as well as potential limitations to overcome in order to make MAIT cells the basis of future, novel therapies for hematological cancers.  \nKEYWORDS  \nMAIT cells, MR1, tumor immunology, immunotherapy, leukemia  \nSince the initial discovery of unconventional T cell subsets in the 1980s, there has been a large interest in the possibility of harnessing the power of gd T cells, CD1-restricted, and more recently, MR1-restricted T cells (MR1T), to treat or prevent diverse pathologies such as autoimmune diseases, infections or cancer. Whereas a great deal of work has been conducted with the two former cell populations, leading to the development of start-up companies and several clinical trials, the field of MR1T cells and their potential as therapeutic candidates is still in its infancy.  \nMucosal-Associated Invariant T cells represent the vast majority ofT cells restricted to the non-classical, MHC-class Ib molecule, MHC-Related 1 (MR1) . Their innate-like  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nrecognition of microbial metabolites, their potent anti-microbial functions, and their localization at mucosal surfaces, have drawn tremendous interest in the context of infections (1–3) . In agreement with MAIT cells being positioned close to mucosal surfaces, several studies have logically focused first on colorectal cancer, followed by analyses of other epithelial cancers (4, 5","cbCaig7P8nQr5eho","https://ap.wps.com/l/cbCaig7P8nQr5eho","pdf",377306,"English","# MAIT cells in hematologic malignancies\n## Current knowledge of MAIT behavior in blood cancers\n## Therapeutic targeting approaches involving MAIT cells\n## Key unresolved questions and limitations","[{\"question\":\"What are mucosal-associated invariant T cells (MAIT) and why are they important?\",\"answer\":\"MAIT cells are MR1-restricted, innate-like T cells that recognize bacterial/fungal metabolites and can produce type 1 cytokines and cytotoxic molecules. Their antimicrobial functions and innate-like behavior make them relevant to tumor immunology.\"},{\"question\":\"What is known about MAIT cells in hematological malignancies?\",\"answer\":\"Fewer studies focus on blood cancers compared with solid tumors. The review describes observations such as reduced circulating MAIT cells in newly diagnosed multiple myeloma and explores how MAIT cells behave in hematological disease.\"},{\"question\":\"Which therapeutic strategies are discussed for targeting MAIT cells?\",\"answer\":\"The review outlines potential approaches to manipulate MAIT cells, including CAR-MAIT, and considers how MAIT cells may respond to other treatments such as checkpoint blockade.\"}]","Mucosal-associated invariant T cells in hematological malignancies - Current knowledge, pending questions | PDF",1790226776,23]