[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-337862-105":59,"doc-detail-337862-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","mtch2-in-metabolic-diseases-neurodegenerative-diseases-cancers-embryonic-development-and-reproduction-review-state-of-the-art-research-summary","MTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and Reproduction - Review - State-of-the-art research summary","","Mitochondrial carrier homolog 2 (MTCH2) is an outer mitochondrial membrane protein in the solute carrier 25 family. First identified in 2000, MTCH2 research has expanded rapidly, with its best-known function involving truncated BID (tBID) to facilitate mitochondrial apoptosis. Genetic variants have been linked to metabolic and neurodegenerative diseases, yet earlier work offered limited therapy guidance. A review synthesizes 131 articles, detailing MTCH2’s structure and disease-associated roles across metabolism, neurodegeneration, cancers, and reproduction through regulating mitochondrial function, apoptosis, metabolic switching, fusion/fission, and EMT.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mtch2-in-metabolic-diseases-neurodegenerative-diseases-cancers-embryonic-development-and-reproduction-review-state-of-the-art-research-summary/337862/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mtch2-in-metabolic-diseases-neurodegenerative-diseases-cancers-embryonic-development-and-reproduction-review-state-of-the-art-research-summary/337862.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is MTCH2 and where is it located in cells?","Question",{"text":112,"@type":113},"MTCH2 is a solute carrier 25 family member located primarily on the outer mitochondrial membrane. It functions as an insertase and as a scramblase, enabling specific substrate and lipid transport roles.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does MTCH2 influence mitochondrial apoptosis?",{"text":117,"@type":113},"MTCH2’s best-known role is binding with truncated BID (tBID) to regulate mitochondrial apoptosis. This pro-apoptosis connection is central to its reported disease-linked functions.",{"name":119,"@type":110,"acceptedAnswer":120},"Which disease areas does the review focus on for MTCH2?",{"text":121,"@type":113},"The review summarizes evidence on MTCH2 in metabolic diseases, neurodegenerative diseases, cancers, and embryonic development and reproduction. It also highlights major mechanisms such as mitochondrial dysfunction and apoptosis regulation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},337862,1790167954,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","Drug Design, Development and Therapy Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nMTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and Reproduction  \nXiaoqing Peng 1–4 , *, Yuanyuan Yang 3 ,4 , *, Ruirui Hou 1 , Longbiao Zhang 1 , Can Shen 3 , Xiaoyan Yang 3 , Zhigang Luo 5 , Zongzhi Yin 3 ,4 , Yunxia Cao 3 ,4  \n1School of Pharmacy, Anhui Medical University, Hefei, People’s Republic of China; 2Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, Hefei, Anhui, People’s Republic of China; 3Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 4The Key National Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), Hefei, People’s Republic of China; 5Department of Cardiology, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China  \n*These authors contributed equally to this work  \nCorrespondence: Yunxia Cao; Zongzhi Yin, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Sushan District, Hefei, Anhui, People’s Republic of China, Email [caoyunxia5972@ahmu.edu.cn](caoyunxia5972@ahmu.edu.cn); [yinzongzhi@ahmu.edu.cn](yinzongzhi@ahmu.edu.cn)  \n\n| Abstract: Mitochondrial carrier homolog 2 (MTCH2) is a member of the solute carrier 25 family, located on the outer mitochondrial membrane. MTCH2 was first identified in 2000. The development in MTCH2 research is rapidly increasing. The most well-known role of MTCH2 is linking to the pro-apoptosis BID to facilitate mitochondrial apoptosis. Genetic variants in MTCH2 have been investigated for their association with metabolic and neurodegenerative diseases, however, no intervention or therapeutic suggestions were provided. Recent studies revealed the physiological and pathological function of MTCH2 in metabolic diseases, neurodegenerative diseases, cancers, embryonic development and reproduction via regulating mitochondrial apoptosis, metabolic shift between glycolysis and oxidative phosphorylation, mitochondrial fusion/fission, epithelial-mesenchymal transition, etc. This review endeavors to assess a total of 131 published articles to summarise the structure and physiological/pathological role of MTCH2, which has not previously been conducted. This review concludes that MTCH2 plays a crucial role in metabolic diseases, neurodegenerative diseases, cancers, embryonic development and reproduction, and the predominant molecular mechanism is regulation of mitochondrial function. This review gives a comprehensive state of current knowledgement on MTCH2, which will promote the therapeutic research of MTCH2 .\u003Cbr>Keywords: Mimp, MTCH2, mitochondrial carrier homolog 2, BID, apoptosis |\n| --- |\n| Introduction\u003Cbr>Mitochondrial carrier homolog 2 (MTCH2) is a member of the solute carrier 25 family, an integral membrane protein known for the role of catalyzing the exchange of substrates across the inner mitochondrial membrane (IMM) . MTCH2 is primarily located on the outer mitochondrial membrane (OMM) rather than the IMM, and functions as an insertase 1 and also a scramblase.2,3 The insertase allows the insertion of cytoplasmic α-helical protein into the outer mitochondrial membrane but not the transfer to the inner mitochondrial membrane.1 The scramblase facilitates bidirectional lipid transport across cell membranes.4 The best-known role of MTCH2 is binding with truncated BID (tBID) to regulate mitochondrial apoptosis.5 Recent studies have demonstrated the physiological and pathological role of MTCH2 in metabolic diseases, neurodegenerative diseases, cancers, embryonic development and reproduction, and the predominant molecular mechanisms are regulating apoptosis, metabolic shift, mitochondrial elongation, epithelial-mesenchymal transition, etc. No review h","cbCaiidFh0qB0D3Q","https://ap.wps.com/l/cbCaiidFh0qB0D3Q","pdf",1897660,11,"English","# Introduction\n## Structure Characteristics of MTCH2\n# MTCH2 in Metabolic Diseases\n## MTCH2 in Neurodegenerative Diseases\n# MTCH2 in Cancers\n## MTCH2 in Embryonic Development and Reproduction","[{\"question\":\"What is MTCH2 and where is it located in cells?\",\"answer\":\"MTCH2 is a solute carrier 25 family member located primarily on the outer mitochondrial membrane. It functions as an insertase and as a scramblase, enabling specific substrate and lipid transport roles.\"},{\"question\":\"How does MTCH2 influence mitochondrial apoptosis?\",\"answer\":\"MTCH2’s best-known role is binding with truncated BID (tBID) to regulate mitochondrial apoptosis. This pro-apoptosis connection is central to its reported disease-linked functions.\"},{\"question\":\"Which disease areas does the review focus on for MTCH2?\",\"answer\":\"The review summarizes evidence on MTCH2 in metabolic diseases, neurodegenerative diseases, cancers, and embryonic development and reproduction. It also highlights major mechanisms such as mitochondrial dysfunction and apoptosis regulation.\"}]","MTCH2 in Metabolic Diseases, Neurodegenerative Diseases, Cancers, Embryonic Development and Reproduction - Review - State-of-the-art research summary | PDF",1790020962,28]