[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-382730-105":59,"doc-detail-382730-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","mrna-vaccine-in-cancer-therapy-current-advance-and-future-outlook-review","mRNA vaccine in cancer therapy - Current advance and future outlook - Review","","Messenger ribonucleic acid (mRNA) vaccines represent a relatively new vaccine class with strong potential in both infectious-disease immunotherapy and cancer. Over the past two years, SARS-CoV-2 mRNA vaccines accelerated research momentum, leading to rapid growth in cancer vaccine studies. Compared with conventional cancer vaccines, mRNA platforms offer efficient protective immune response generation, relatively low side effects, and reduced acquisition cost. This review summarizes cancer vaccine development, mRNA cancer vaccine mechanisms, recent advances across tumour treatments, and outlines challenges and future directions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/mrna-vaccine-in-cancer-therapy-current-advance-and-future-outlook-review/382730/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/mrna-vaccine-in-cancer-therapy-current-advance-and-future-outlook-review/382730.png","ImageObject",300,407,{"name":92,"@type":93},"นรินทร์","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the focus of the review on mRNA vaccines for cancer therapy?","Question",{"text":112,"@type":113},"The review summarizes the development of cancer vaccines and mRNA cancer vaccines, discusses potential biological mechanisms, and reviews latest progress across tumour treatments while addressing challenges and future directions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are mRNA cancer vaccines considered advantageous compared with conventional cancer vaccines?",{"text":117,"@type":113},"They can efficiently produce protective immune responses, show relatively low side effects, and require lower acquisition cost.",{"name":119,"@type":110,"acceptedAnswer":120},"How has SARS-CoV-2 mRNA vaccine research influenced cancer vaccine studies?",{"text":121,"@type":113},"SARS-CoV-2 mRNA vaccines contributed strongly over the past two years against SARS-CoV-2 and helped trigger a research boom, especially for cancer vaccines.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},382730,1790318626,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336475104957,"https://ap-avatar.wpscdn.com/avatar/22000c4c6bd8a5076e1?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787554080175789136","DOI: 10.1002/ctm2.1384  \nREVIEW  \nmRNA vaccine in cancer therapy: Current advance and future outlook  \nYouhuai Li1  Mina Wang2, 3  Xueqiang Peng4  Yingying Yang5  Qishuang Chen2  Jiaxing Liu4  Qing She1  Jichao Tan1  Chuyuan Lou6 Zehuan Liao7, 8   Xuexin Li9   \n1 Department of Breast Surgery, Baoji Municipal Central Hospital, Weibin District, Baoji, Shaanxi, China  \n2 Graduate School, Beijing University of Chinese Medicine, Beijing, China  \n3 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, China  \n4 Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, China  \n5 Clinical Research Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China  \n6 Department of Ophthalmology, Xi’an People’s Hospital (Xi’an Fourth Hospital), Xi’an, Shaanxi, China  \n7 School of Biological Sciences, Nanyang Technological University, Singapore, Singapore  \n8 Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Sweden  \nGraphical Abstract  \n∙ Messenger ribonucleic acid vaccines deliver tumour antigens to antigenpresenting cells (APCs) for the presentation to immune cells (CD8+ T, CD4+ T) via major histocompatibility complex classes I and II.  \nClin. Transl. Med. 2023;13:e1384 .  \n[https://doi.org/10.1002/ctm2.1384](https://doi.org/10.1002/ctm2.1384)  \n[wileyonlinelibrary.com/journal/ctm2](wileyonlinelibrary.com/journal/ctm2)  \nLI et al.  \n9 Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Biomedicum, Stockholm, Sweden  \nCorrespondence  \nXuexin Li, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Biomedicum, Stockholm, Sweden. [Email:](Email: Xuexin.li@ki.se)[ Xuexin.li@ki.se](Email: Xuexin.li@ki.se)  \nZehuan Liao, School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. [Email:](Email: Liao0058@e.ntu.edu.sg)[ Liao0058@e.ntu.edu.sg](Email: Liao0058@e.ntu.edu.sg)  \nChuyuan Lou, Department of Ophthalmology, Xi’an People’s Hospital (Xi’an Fourth Hospital), Xi’an, Shaanxi, China. [Email:](Email: Louchuyuan05@163.com)[ Louchuyuan05@163.com](Email: Louchuyuan05@163.com)  \n∙ Innate immune activity can also be induced through APC-expressed pattern recognition receptors.  \n∙ Antigen receptors (chimeric antigen receptors and T cell receptors) can be introduced into lymphocytes.  \n∙ Expressions of immunomodulatory proteins in different cell types, such as other monoclonal antibody formats, chemokine receptors, costimulatory ligands and Toll-like receptors, etc are illustrated.  \n.  \nDOI: 10.1002/ctm2.1384  \nREVIEW  \nmRNA vaccine in cancer therapy: Current advance and future outlook  \nYouhuai Li1  Mina Wang2, 3  Xueqiang Peng4  Yingying Yang5  Qishuang Chen2  Jiaxing Liu4  Qing She1  Jichao Tan1  Chuyuan Lou6 Zehuan Liao7, 8   Xuexin Li9   \n1 Department of Breast Surgery, Baoji Municipal Central Hospital, Weibin District, Baoji, Shaanxi, China  \n2 Graduate School, Beijing University of Chinese Medicine, Beijing, China  \n3 Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, China  \n4 Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, China  \n5 Clinical Research Center, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China  \n6 Department of Ophthalmology, Xi’an People’s Hospital (Xi’an Fourth Hospital), Xi’an, Shaanxi, China  \n7 School of Biological Science","cbCaigsJQVp7uGgr","https://ap.wps.com/l/cbCaigsJQVp7uGgr","pdf",3154410,28,"English","# Abstract\n## Graphical abstract\n## Correspondence\n## Funding information","[{\"question\":\"What is the focus of the review on mRNA vaccines for cancer therapy?\",\"answer\":\"The review summarizes the development of cancer vaccines and mRNA cancer vaccines, discusses potential biological mechanisms, and reviews latest progress across tumour treatments while addressing challenges and future directions.\"},{\"question\":\"Why are mRNA cancer vaccines considered advantageous compared with conventional cancer vaccines?\",\"answer\":\"They can efficiently produce protective immune responses, show relatively low side effects, and require lower acquisition cost.\"},{\"question\":\"How has SARS-CoV-2 mRNA vaccine research influenced cancer vaccine studies?\",\"answer\":\"SARS-CoV-2 mRNA vaccines contributed strongly over the past two years against SARS-CoV-2 and helped trigger a research boom, especially for cancer vaccines.\"}]","mRNA vaccine in cancer therapy - Current advance and future outlook - Review | PDF",1790252113,71]