[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-377947-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-377947-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","mrna-expression-of-caspase-14-in-skin-epithelial-malignancies","mRNA expression of caspase 14 in skin epithelial malignancies","","mRNA expression of caspase 14 was analyzed in a prospective cohort of 56 patients with skin epithelial malignancies. Patients were divided into a control group (n=21) and a study group (n=35). Caspase 14 mRNA expression was lower in non-lesional skin from basal cell cancer and squamous cell cancer patients than in non-lesional samples from actinic keratosis patients combined with controls. Lower expression was also observed in non-lesional skin from BCC/SCC compared with matched lesional samples. The findings suggest prognostic potential and define next research objectives.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/mrna-expression-of-caspase-14-in-skin-epithelial-malignancies/377947/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/mrna-expression-of-caspase-14-in-skin-epithelial-malignancies/377947.png","ImageObject",300,407,{"name":42,"@type":43},"Rhys","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the goal of the study on caspase 14?","Question",{"text":63,"@type":64},"The study aimed to analyze mRNA expression of caspase 14 in groups of skin epithelial malignancies and assess its possible clinical relevance.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients grouped in the material and methods section?",{"text":68,"@type":64},"A total of 56 patients were enrolled: a control group (n=21) and a study group (n=35).",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about caspase 14 mRNA levels?",{"text":72,"@type":64},"Caspase 14 mRNA expression was lower in non-lesional skin of basal cell cancer and squamous cell cancer patients compared with combined non-lesional samples from actinic keratosis patients and controls, and it was also lower in non-lesional BCC/SCC groups versus lesional BCC/SCC samples.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},377947,1790376816,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},687207024643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Original paper  \nmRNA expression of caspase 14 in skin epithelial malignancies  \nAgnieszka Markiewicz1, Dawid Sigorski2, Mateusz Markiewicz3, Waldemar J. Placek1, Agnieszka Barbara Owczarczyk-Saczonek1  \n1Department and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury, Olsztyn, Poland  \n2Department of Oncology, University of Warmia and Mazury, Olsztyn, Poland 3Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland  \nAdv Dermatol Allergol 2023; XL (2): 315–320 DOI: [https://doi.org/10.5114/ada.2023.127646](https://doi.org/10.5114/ada.2023.127646)  \nAbstract  \nIntroduction: The skin is the largest organ in the human body and it is also a complex organ. Its protective function is properly maintained due to its continuous renewal. Malignancies develop when the balance between proliferation and cell death is dysregulated in skin cells. Skin epithelial cancers are the most common neoplasms in humans. Although caspases are proteins which regulate the cell cycle and cell death, caspase 14 is a unique representative of the caspase family which does not participate in apoptosis. The detailed role of caspase 14 in skin epithelial malignancies has not been elucidated.  \nMaterial and methods: We performed a prospective study aimed at the analysis of the mRNA expression of caspase 14 in groups of skin epithelial malignancies. We enrolled 56 patients (control group n = 21, study group n = 35) . The mRNA expression of caspase 14 was lower in the non-lesional skin of patients with basal cell cancer or squamous cell cancer compared to a combined group of non-lesional samples from actinic keratosis patients and the control group.  \nResults: The prognostic potential of caspase 14 mRNA is suggested when trying to identify patients predisposed to skin cancer. Moreover, the expression level was lower in combined groups of non-lesional skin obtained from patients with basal cell cancer (BCC)/squamous cell cancer (SCC) in comparison with lesional samples obtained from patients with BCC/SCC.  \nConclusions: We present primary results of a pilot study and define further goals for research continuation.  \nKey words: caspase 14, skin cancer, squamous cell cancer, basal cell cancer.  \nIntroduction  \nThe proper function of the skin involves the protection from pathogens and physical damage. The skin consists of the superficial epidermis and the dermis which is located deeper. The continuous renewal of skin cells is attained in the process of cornification to maintain the protective function of the skin. The division of the basal layer of the epidermis is followed by cell migration to the surface, their maturation and death, and the formation of the stratum corneum which is the outermost epidermal layer [1] . The process of cornification is of special interest, because it combines the phenomenon of terminal differentiation and programmed cell death, and plays a particular role in non-oncological and oncological  \ndisorders [2] . Keratinocyte-derived non-melanoma skin cancers, i. e., basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin cancers [3, 4] . Skin cancers are a group of the most common neoplasms in humans. However, the actual incidence of epithelial skin cancer is difficult to estimate, as it is rarely included in cancer registries and, sometimes, both pathologies are registered together. The incidence of both cancers has been growing over the past decades [5, 6] . Basal cell cancer is the most common skin cancer with a low metastatic potential. Chronic sun exposure is the major risk factor for BCC development making the head and neck region the most common locations of BCC. Therefore, numerous patients who developed BCC are subsequently diagnosed with other malignant lesions.  \nAddress for correspondence: Agnieszka Markiewicz MD, Department and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of","cbCaijwAVnQEVIGh","https://ap.wps.com/l/cbCaijwAVnQEVIGh","pdf",128668,"English","# Abstract\n# Introduction\n# Material and methods\n# Results\n# Conclusions\n# Key words","[{\"question\":\"What was the goal of the study on caspase 14?\",\"answer\":\"The study aimed to analyze mRNA expression of caspase 14 in groups of skin epithelial malignancies and assess its possible clinical relevance.\"},{\"question\":\"How were patients grouped in the material and methods section?\",\"answer\":\"A total of 56 patients were enrolled: a control group (n=21) and a study group (n=35).\"},{\"question\":\"What did the results show about caspase 14 mRNA levels?\",\"answer\":\"Caspase 14 mRNA expression was lower in non-lesional skin of basal cell cancer and squamous cell cancer patients compared with combined non-lesional samples from actinic keratosis patients and controls, and it was also lower in non-lesional BCC/SCC groups versus lesional BCC/SCC samples.\"}]","mRNA expression of caspase 14 in skin epithelial malignancies | PDF",1790227764,15]