[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332352-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332352-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","mri-features-of-breast-cancer-immunophenotypes-with-a-focus-on-luminal-estrogen-receptor-low-positive-invasive-carcinomas","MRI features of breast cancer immunophenotypes with a focus on luminal estrogen receptor low positive invasive carcinomas","","MRI features across breast cancer immunophenotypes are compared with special attention to estrogen receptor (ER)-low-positive invasive carcinomas. In a retrospective, single-centre IRB-approved cohort of 398 patients, ER-low positivity was defined as ER staining in 1–10% of tumor cells. Pretreatment MRI was evaluated using the 5th edition BI-RADS lexicon. Significant differences were found in mass shape, margins, internal enhancement, and kinetic curve delayed phase. ER-low-positive tumors showed MRI findings similar to triple-negative tumors, supporting radiopathological correlation and treatment planning.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/mri-features-of-breast-cancer-immunophenotypes-with-a-focus-on-luminal-estrogen-receptor-low-positive-invasive-carcinomas/332352/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/mri-features-of-breast-cancer-immunophenotypes-with-a-focus-on-luminal-estrogen-receptor-low-positive-invasive-carcinomas/332352.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How were breast cancer immunophenotypes defined in this study?","Question",{"text":63,"@type":64},"Immunophenotypes were classified using estrogen receptor (ER) status and staining patterns, with ER-low positive defined as ER staining in 1–10% of tumor cells. Tumors were then compared across subgroups including luminal A, luminal B, ER-low positive, HER2-overexpressing, and triple negative.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What MRI features differed significantly between immunophenotypes?",{"text":68,"@type":64},"Correlation analysis showed statistically significant differences in mass shape, margins, internal enhancement, and the delayed phase of the kinetic curve. Shape and rim enhancement were most frequent in triple-negative and luminal ER-low-positive tumors, while spiculated margins were common in luminal A and luminal B.",{"name":70,"@type":61,"acceptedAnswer":71},"What conclusion was drawn about luminal ER-low-positive tumors?",{"text":72,"@type":64},"Luminal ER-low-positive tumors presented with MRI findings similar to triple-negative tumors, suggesting MRI can support adequate radiopathological correlation and therapeutic planning in these patients.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332352,1790149028,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nMRI features of breast cancer immunophenotypes with a focus on luminal estrogen receptor low positive invasive carcinomas  \nCarla ChizuruTajima1,2*, Fernanda Pini Sapata Gonçalves Arruda1, Victor Chequer Mineli1, Julianna Moura Ferreira1, Barbara Beltrame Bettim3,  \nCynthia Aparecida Bueno de Toledo Osório4, Marina Sonagli5 &  \nAlmir Galvão Vieira Bitencourt6  \nTo compare the magnetic resonance imaging (MRI) features of different immunophenotypes of breast carcinoma of no special type (NST), with special attention to estrogen receptor (ER)-low-positive breast cancer. This retrospective, single-centre, Institutional Review Board (IRB)-approved study included 398 patients with invasive breast carcinoma. Breast carcinomas were classified as ER-lowpositive when there was ER staining in 1–10% of tumour cells. Pretreatment MRI was reviewed to assess the tumour imaging features according to the 5th edition of the Breast Imaging Reporting and Data System (BI-RADS) lexicon. Of the 398 cases, 50 (12.6%) were luminalA, 191 (48.0%) were luminal B, 26 (6.5%) were luminal ER-low positive, 64 (16.1%) were HER2-overexpressing, and 67 (16.8%) were triple negative. Correlation analysis between MRI features and tumour immunophenotype showed statistically significant differences in mass shape, margins, internal enhancement and the delayed phase of the kinetic curve. An oval or round shape and rim enhancement were most frequently observed in triple-negative and luminal ER-low-positive tumours. Spiculated margins were most common in luminalA and luminal B tumours. A persistent kinetic curve was more frequent in luminal A tumours, while a washout curve was more common in the triple-negative, HER2-overexpressing and luminal ER-low-positive immunophenotypes. Multinomial regression analysis showed that luminal ER-low-positive tumours had similar results to triple-negative tumours for almost all variables. Luminal ER-low-positive tumours present with similar MRI findings to triple-negative tumours, which suggests that MRI can play a fundamental role in adequate radiopathological correlation and therapeutic planning in these patients.  \nKeywords Breast cancer, Estrogen receptors, Magnetic resonance imaging, Triple-negative breast neoplasms  \nAbbreviations  \nMRI  \nER  \nIRB  \nBI-RADSIHC  \nHR  \nPgR  \nASCO  \nCAP  \nNST  \nMagnetic resonance imaging  \nEstrogen receptor  \nInstitutional Review Board  \nBreast Imaging Reporting and Data System Immunohistochemical  \nHormone receptor  \nProgesterone receptor  \nAmerican Society of Clinical Oncology College of American Pathologists No special type  \n1Imaging Department, Graduate Program of A. C. Camargo Cancer Center, São Paulo, SP, Brazil. 2Imaging Department, A Beneficência Portuguesa de São Paulo, São Paulo, Brazil. 3Department of Epidemiology and Statistics, A. C. Camargo Cancer Center, São Paulo, Brazil. 4Department of Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil. 5Department of Breast Surgery, A. C. Camargo Cancer Center, São Paulo, Brazil. 6Department of  \nImaging, A.C. Camargo Cancer Center, São Paulo, Brazil.* email: [carlatajima@gmail.com](carlatajima@gmail.com)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \nDCIS Ductal carcinoma in situ  \nDISH Dual in situ hybridization  \nFISH Fluorescence in situ hybridization  \nBreast cancer is a heterogeneous disease. Currently, treatment planning is based not only on anatomic staging but also, and perhaps more importantly, on prognostic biomarkers1. Immunohistochemical (IHC) staining for hormone receptors (HRs) and HER2 allows breast cancers to be classified into different immunophenotypesand has great practical importance for treatment. The most common immunophenotype of breast cancer is the luminal phenotype, which is characterized by positive expression of HRs and usually benefits from endocrine therapy. However, there is great heterogeneity even w","cbCaieiuPCiTu8Cj","https://ap.wps.com/l/cbCaieiuPCiTu8Cj","pdf",1447281,"English","# Material and methods\n## Patient selection and imaging assessment\n## ER-low-positive definition and BI-RADS review\n## Statistical analysis and correlations","[{\"question\":\"How were breast cancer immunophenotypes defined in this study?\",\"answer\":\"Immunophenotypes were classified using estrogen receptor (ER) status and staining patterns, with ER-low positive defined as ER staining in 1–10% of tumor cells. Tumors were then compared across subgroups including luminal A, luminal B, ER-low positive, HER2-overexpressing, and triple negative.\"},{\"question\":\"What MRI features differed significantly between immunophenotypes?\",\"answer\":\"Correlation analysis showed statistically significant differences in mass shape, margins, internal enhancement, and the delayed phase of the kinetic curve. Shape and rim enhancement were most frequent in triple-negative and luminal ER-low-positive tumors, while spiculated margins were common in luminal A and luminal B.\"},{\"question\":\"What conclusion was drawn about luminal ER-low-positive tumors?\",\"answer\":\"Luminal ER-low-positive tumors presented with MRI findings similar to triple-negative tumors, suggesting MRI can support adequate radiopathological correlation and therapeutic planning in these patients.\"}]","MRI features of breast cancer immunophenotypes with a focus on luminal estrogen receptor low positive invasive carcinomas | PDF",1789997818,25]