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Ferroptosis, an iron-dependent form of cell death, is increasingly linked to multiple cancers, yet its regulatory mechanisms in ovarian cancer patients remain insufficiently defined. Using bioinformatics analyses and experimental validation, the study identifies ferroptosis-related lncRNAs, evaluates prognostic effects, defines molecular subtypes, and investigates mechanisms for selected lncRNAs. Results suggest subtype-dependent tumor-associated pathway activation and ferroptotic condition–induced lncRNA upregulation, providing new insights.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/molecular-subtype-classifcation-and-mechanistic-investigation-based-on-ferroptosis-related-lncrnas-in-ovarian-cancer/352857/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/molecular-subtype-classifcation-and-mechanistic-investigation-based-on-ferroptosis-related-lncrnas-in-ovarian-cancer/352857.png","ImageObject",300,407,{"name":92,"@type":93},"Bintang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main objective regarding ovarian cancer?","Question",{"text":112,"@type":113},"To identify ferroptosis-related lncRNAs associated with ovarian cancer and clarify their underlying regulatory mechanisms using bioinformatics and experimental validation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were ferroptosis-related lncRNAs and their prognostic value assessed?",{"text":117,"@type":113},"Ferroptosis-related lncRNAs were identified in ovarian cancer, and their prognostic value was evaluated using univariate Cox analysis.",{"name":119,"@type":110,"acceptedAnswer":120},"What key finding links molecular subtypes to outcomes in this study?",{"text":121,"@type":113},"Consensus clustering defined subtypes of ferroptosis-related lncRNAs; Cluster 2 showed a low tumor microenvironment score and was associated with a poorer prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},352857,1790137485,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962085564381,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Genetics Research  \nRESEARCH ARTICLE OPEN ACCESS  \nMolecular Subtype Classifcation and Mechanistic Investigation Based on Ferroptosis-Related lncRNAs in Ovarian Cancer  \nQianru Li1 | Mengyao Lv1 | Aijie Zhang2 | Xue Liu2 | Wanting Lu2 | Min Shao1  | Limian Cao1   \n1Department of Critical Care Medicine, The First Afliated Hospital of Anhui Medical University, Hefei, Anhui 230001, China | 2Department of  \nImmunology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, China Correspondence: Limian Cao ([caolimian@ahmu.edu.cn](caolimian@ahmu.edu.cn))  \nReceived: 3 March 2025 | Revised: 5 January 2026 | Accepted: 16 February 2026  \nAcademic Editor: Vindhya Mohindra  \nKeywords: AC027348.1 | ferroptosis | lncRNA | molecular subtypes | ovarian cancer  \nABSTRACT  \nOvarian cancer (OC) ranks among the most prevalent malignant tumors in women, contributing signifcantly to mortality rates. This disease exhibits considerable heterogeneity, characterized by intricate molecular and genetic alterations. Ferroptosis, a distinct form of cell death, has emerged as a critical factor in various cancers, including OC. However, the regulatory mechanisms underlying ferroptosis in OC patients remain unclear and require further investigation. This study aimed to identify lncRNA associated with OC and elucidate the underlying mechanisms through bioinformatics methods and experimental validation. Ferroptosis-related lncRNAs (FRLs) was identifed in OC, and its prognostic value was assessed using univariate Cox analysis. Additionally, the molecular subtypes of FRLs were evaluated through the ConsensusClusterPlus software package. Notably, Cluster 2 exhibited a lowTME score, which was linked to a poorer prognosis. The GSEA suggested that Cluster 2 shared similarities with other clusters associated with worse survival outcomes, likely due to the activation of tumor-associated pathways. In vitro experiments further confrmed that certain lncRNAs could be upregulated under ferroptotic conditions. We focused on two lncRNAs, AC027348.1 and TRAM2-AS1, which were not noticed before and were signifcantly upregulated, to explore their regulatory efects on ferroptosis. The underlying mechanisms were preliminarily investigated through transcriptome sequencing. In summary, our fndings ofer new insights into the pathogenesis of OC, particularly regarding the role of lncRNAs related to ferroptosis.  \n1 | Introduction  \nOvarian cancer (OC) is one of the most prevalent cancers among women and a leading cause of mortality due to gynecologic malignancies [1]. According to the latest global cancer statistics from 2020, there were 313,959 new cases of OC and approximately 207,000 deaths, ranking it as the eighth leading cause of cancerrelated deaths in women [2]. The high mortality rate is attributed to  \ntumor heterogeneity, the absence of reliable early diagnostic methods, and a signifcant incidence of chemotherapy-resistant recurrences. Despite advancements in chemotherapy and surgical interventions, the 5-year survival rate for patients with advanced OC remains low [3, 4]. In fact, while the 10-year survival rate for OC patients is reported at 55%, it drops to a mere 15% for those with advanced disease. Consequently, efective diagnostic markers and therapeutics are identifed [5].  \n\n| Qianru Li, Mengyao Lv, Aijie Zhang contributed equally. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.\u003Cbr>Copyright © 2026 Qianru Li et al. Genetics Research published by John Wiley & Sons Ltd. |\n\nGenetics Research, 2026; 2026:4503115 1 of 18  \n[https://doi.org/10.1155/genr/4503115](https://doi.org/10.1155/genr/4503115)  \nStrategies are essential to enhance the prognosis for patients with OC. Ferroptosis is a distinct form of iron-dependent programmed cell death that difers signifcantly from necrosis, ","cbCaijqXE8vt1XVJ","https://ap.wps.com/l/cbCaijqXE8vt1XVJ","pdf",4372246,18,"English","# Introduction\n# Materials and Methods (Overview)\n## Identification of ferroptosis-related lncRNAs\n## Prognostic assessment via univariate Cox analysis\n## Molecular subtype evaluation\n## Functional enrichment analysis (GSEA)\n## Experimental validation (in vitro)\n## Mechanistic exploration (transcriptome sequencing)\n# Results (Overview)\n## Molecular subtypes and TME association\n## Prognostic differences among clusters\n## Candidate lncRNAs and ferroptotic regulation\n# Discussion (Overview)","[{\"question\":\"What is the study’s main objective regarding ovarian cancer?\",\"answer\":\"To identify ferroptosis-related lncRNAs associated with ovarian cancer and clarify their underlying regulatory mechanisms using bioinformatics and experimental validation.\"},{\"question\":\"How were ferroptosis-related lncRNAs and their prognostic value assessed?\",\"answer\":\"Ferroptosis-related lncRNAs were identified in ovarian cancer, and their prognostic value was evaluated using univariate Cox analysis.\"},{\"question\":\"What key finding links molecular subtypes to outcomes in this study?\",\"answer\":\"Consensus clustering defined subtypes of ferroptosis-related lncRNAs; Cluster 2 showed a low tumor microenvironment score and was associated with a poorer prognosis.\"}]","Molecular Subtype Classifcation and Mechanistic Investigation Based on Ferroptosis-Related lncRNAs in Ovarian Cancer | PDF",1790101758,45]