[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-327791-105":59,"doc-detail-327791-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","molecular-mechanisms-of-human-papilloma-virus-related-skin-cancers-a-review","Molecular mechanisms of human papilloma virus related skin cancers - A review","","The human papillomavirus (HPV) is a member of the Papillomaviridae family, consisting of small double-stranded DNA viruses. While about 90% of HPV infections remain asymptomatic and resolve spontaneously, high-risk strains may generate preneoplastic lesions with increased oncogenic potential. HPV-driven malignancies are known in several mucosal sites, yet the determinants governing cutaneous initiation and progression are less clear. This review summarizes epidemiological, pathophysiological, and molecular mechanisms linking HPV to benign and malignant skin lesions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/molecular-mechanisms-of-human-papilloma-virus-related-skin-cancers-a-review/327791/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/molecular-mechanisms-of-human-papilloma-virus-related-skin-cancers-a-review/327791.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why do most HPV infections not lead to skin cancer?","Question",{"text":112,"@type":113},"Approximately 90% of HPV infections occur without symptoms and resolve spontaneously. Only high-risk viral strains are described as having the potential to drive preneoplastic lesions toward cancerous change.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What factors are emphasized for HPV involvement in skin malignancies?",{"text":117,"@type":113},"The review highlights ongoing discussion of how HPV contributes to initiation and progression in skin cancers, with most data focusing on beta HPV strains alongside ultraviolet radiation (UVR) and other environmental or genetic factors.",{"name":119,"@type":110,"acceptedAnswer":120},"Which types of skin cancers does the review connect to HPV?",{"text":121,"@type":113},"It focuses on HPV-related mechanisms in both non-melanocytic cancers such as basal cell carcinoma and malignant squamous cell carcinoma, and it also addresses melanocytic skin cancers including melanoma.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},327791,1790230478,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","®  \n Narrative Review   \nMolecular mechanisms of human papilloma virus related skin cancers  \nA review  \nElena-Codruta Cozma, MD, PhDa ,b , Laura Mădălina Banciu, MDb , Ana Maria Celarel, MDb , Elena Soare, MDb , Bahadar S. Srichawla, MDc , Vincent Kipkorir, MDd ,* and Mihnea-Alexandru Găman, MD, PhDe ,f  \n\n| Abstract\u003Cbr>The human papillomavirus (HPV) belongs to the Papillomaviridae family of viruses which includes small, double-stranded DNA viral agents. Approximately 90% of HPV infections occur asymptomatically and resolve spontaneously. However, infection with high-risk viral strains can lead to the development of preneoplastic lesions, with an increased propensity to become cancerous. The location of these malignancies includes the oral cavity, cervix, vagina, anus, and vulva, among others. The role of HPV in carcinogenesis has already been demonstrated for the aforementioned neoplasia. However, regarding skin malignancies, the mechanisms that pinpoint the role played by HPV in their initiation and progression still elude our sight. Until now, the only fully understood mechanism of viral cutaneous oncogenesis is that of human herpes virus 8 infection in Kaposi sarcoma. In the case of HPV infection, however, most data focus on the role that beta strains exhibit in the oncogenesis of cutaneous squamous cell carcinoma (cSCC), along with ultraviolet radiation (UVR) and other environmental or genetic factors. However, recent epidemiological investigations have highlighted that HPV could also trigger the onset of other non-melanocytic, for example, basal cell carcinoma (BCC), and/or melanocytic skin cancers, for example, melanoma. Herein, we provide an overview of the role played by HPV in benign and malignant skin lesions with a particular focus on the main epidemiological, pathophysiological, and molecular aspects delineating the involvement of HPV in skin cancers. |\n| --- |\n| Abbreviations: BCC = basal cell carcinoma, BP = Bowenoid papulosis, CA = condyloma accuminata, cSCC = cutaneoussquamous cell carcinoma, EQ = Erythroplasia of Queyrat, HPV = human papillomavirus, HSPG = heparan sulfate proteoglycan, UVR = ultraviolet radiation. |\n| Keywords: Bowen disease, Bowenoid papulosis, HPV, skin cancers, squamous cell carcinoma |\n\n1. Introduction  \nThe human papillomavirus (HPV) belongs to the Papillomaviridae family of viruses, which includes small, double-stranded DNA viruses. More than 200 HPV genotypes have been recorded until now. Approximately 90% of HPV infections occur asymptomatically and resolve spontaneously.[1,2] In some cases, cutaneous lesions such as cutaneous and genital warts may occur and persist, requiring therapeutic interventions. Moreover, infection with high-risk viral strains can lead to the appearance of preneoplastic lesions, with an increased propensity to become cancerous. The location of these malignancies includes the oral cavity, cervix, vagina, anus, and vulva among others. [3] Cervical cancer is the fourth most prevalent cancer among women, and HPV is its most  \ncommon cause. [4] Although in the case of cancers with the locations mentioned above, the role of HPV in carcinogenesis is known, regarding skin cancers, the mechanisms by which HPVis involved in the initiation and progression of the disease are still being discussed. Until now, the only fully understood mechanism of viral cutaneous oncogenesis is that of human herpes virus 8 infection in Kaposi sarcoma. [5] In the case of HPV infection, however, most data focus on the role that beta strains have in the oncogenesis of cutaneous squamous cell carcinoma (cSCC), along with ultraviolet radiation (UVR) and other environmental or genetic factors. [6] However, recent studies try to explain the role of HPV in other non-melanocytic (basal cell carcinoma [BCC]) and melanocytic (melanoma) skin cancers, as a result of the epidemiological data obtained (see Section 2) .  \nE-CC and LMB, AMC, and ES contributed equally to this work.  \nThe authors have no f","cbCaidDn4mOsoDfa","https://ap.wps.com/l/cbCaidDn4mOsoDfa","pdf",612158,"English","# Abstract\n# Introduction\n# Epidemiology of HPV-related skin lesions","[{\"question\":\"Why do most HPV infections not lead to skin cancer?\",\"answer\":\"Approximately 90% of HPV infections occur without symptoms and resolve spontaneously. Only high-risk viral strains are described as having the potential to drive preneoplastic lesions toward cancerous change.\"},{\"question\":\"What factors are emphasized for HPV involvement in skin malignancies?\",\"answer\":\"The review highlights ongoing discussion of how HPV contributes to initiation and progression in skin cancers, with most data focusing on beta HPV strains alongside ultraviolet radiation (UVR) and other environmental or genetic factors.\"},{\"question\":\"Which types of skin cancers does the review connect to HPV?\",\"answer\":\"It focuses on HPV-related mechanisms in both non-melanocytic cancers such as basal cell carcinoma and malignant squamous cell carcinoma, and it also addresses melanocytic skin cancers including melanoma.\"}]","Molecular mechanisms of human papilloma virus related skin cancers - A review | PDF",1789978050,23]