[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-43181-en":3,"doc-seo-43181-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":21,"is_downloadable":21,"audit_status":21,"page_count":22,"language":23,"language_code":24,"site_id":25,"html_lang":24,"table_of_contents":26,"faqs":27,"seo_title":13,"seo_description":14,"update_tm":28,"read_time":29},43181,1099514068035,"Ezra","https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",8,"Research & Report","Molecular Interactions Underlying Dissolution Trends in Cannabidiol Polymer Amorphous Solid Dispersions","Cannabidiol (CBD) is a promising therapeutic agent, yet limited by poor aqueous solubility. Amorphous solid dispersions (ASDs) improve solubility by embedding APIs within a polymer matrix. This study examines CBD interactions with PVP, PVP/VA, HPMCP, HPMCAS, and PMMA using experiments and molecular dynamics. Analyses show positive ideal-mixing deviations from stable polymer–CBD hydrogen bonds and negative deviations from disruption of polymer–polymer hydrogen bonding, while polymer hydrophobicity worsens CBD dissolution. Results inform ASD formulation strategies.","9 July 2024  \nMolecular Interactions Underlying Dissolution Trends in Cannabidiol-Polymer Amorphous Solid Dispersions  \nBaris Ugur1, Nicholas Caggiano1, Stephanie Monson1, Alexander Bechtold1, Yejoon Seo1, Robert Prud'homme1, Rodney  \n1 1 Priestley , Michael Webb  \n1. Princeton University  \nAbstract  \nCannabidiol (CBD) is viewed as promising therapeutic agent against a variety of health ailments; however, its efficacy is limited by poor aqueous solubility. Amorphous solid dispersions (ASDs) can enhance the solubility of therapeutics by distributing it throughout a polymer matrix. In consideration of ASD formulations with CBD, we investigate the interactions of CBD with various polymers: polyvinylpyrrolidone (PVP), polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer, hydroxypropyl methylcel- lulose phthalate (HPMCP), hydroxypropyl methylcellulose acetate succinate (HPM- CAS), and poly(methyl methacrylate) (PMMA) . Both experiment and molecular dynamics simulation reveal diverse mixing behavior amongst the set of polymers. Detailed structural and nano-scale interaction analyses suggest that positive deviations from ideal-mixing behavior arise from the formation of stable polymer-CBD hydrogen bonds whereas negative deviations are associated with disruptions to the polymer- polymer hydrogen-bond network. Polymer-water interaction analyses indicate the significance of polymer hydrophobicity that can lead to poor dissolution of CBD. These results have implications for drug dissolution rates based on how CBD and water interacts with each polymer. Furthermore, these insights may be used to guide ASD formulations for CBD or other small-molecule therapeutic agents.  \nKeywords  \nactive pharamceutical ingredient, hydrophobicity, hydrogen-bonding, mixing, glass transition  \nPosted on 9 July 2024—CC-BY-NC 4.0—This is a preprint and has not been peer reviewed. Data may be preliminary.—[https://](https://)[ ](https://)[doi.org/10.26434/chemrxiv-2024-r89vp](doi.org/10.26434/chemrxiv-2024-r89vp)  \nMolecular Interactions Underlying Dissolution Trends in Cannabidiol-Polymer Amorphous Solid  \nDispersions  \nBaris E. Ugur, Nicholas J. Caggiano, Stephanie Monson, Alexander G.  \nBechtold, Yejoon Seo, Robert K. Prud’homme, Rodney D. Priestley, and  \nMichael A. Webb∗  \nDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ,  \nUSA  \nE-mail: [mawebb@princeton.edu](mawebb@princeton.edu)  \nAbstract  \nCannabidiol (CBD) is viewed as promising therapeutic agent against a variety of health ailments; however, its efficacy is limited by poor aqueous solubility. Amorphous solid dispersions (ASDs) can enhance the solubility of therapeutics by distributing it throughout a polymer matrix. In consideration of ASD formulations with CBD, we investigate the interactions of CBD with various polymers: polyvinylpyrrolidone (PVP), polyvinylpyrrolidone/vinyl acetate (PVP/VA) copolymer, hydroxypropyl methylcellulose phthalate (HPMCP), hydroxypropyl methylcellulose acetate succinate (HPMCAS), and poly(methyl methacrylate) (PMMA) . Both experiment and molecular dynamics simulation reveal diverse mixing behavior amongst the set of polymers. Detailed structural and nano-scale interaction analyses suggest that positive deviations from ideal-mixing behavior arise from the formation of stable polymer-CBD hydrogen  \n1  \n[https://doi.org/10.26434/chemrxiv-2024-r89vp](https://doi.org/10.26434/chemrxiv-2024-r89vp ORCID:)[ ORCID:](https://doi.org/10.26434/chemrxiv-2024-r89vp ORCID:) [https://orcid.org/0000-0002-7420-4474 Content](https://orcid.org/0000-0002-7420-4474 Content) not peer-reviewed by ChemRxiv. License: CC BY-NC 4.0  \nbonds whereas negative deviations are associated with disruptions to the polymerpolymer hydrogen-bond network. Polymer-water interaction analyses indicate the significance of polymer hydrophobicity that can lead to poor dissolution of CBD. These results have implications for drug dissolution rates based on how CBD and water interact","cbCaihpUjYQ0o07O","https://ap.wps.com/l/cbCaihpUjYQ0o07O","pdf",18211913,2,1,34,"English","en",105,"# Abstract\n# Introduction","[{\"question\":\"Why is CBD dissolution a limiting factor for its therapeutic effectiveness?\",\"answer\":\"CBD has poor aqueous solubility and high lipophilicity, which reduce bioavailability and slow dissolution. The document frames solubility as a key barrier for oral effectiveness.\"},{\"question\":\"Which polymers are investigated for CBD-containing ASD formulations?\",\"answer\":\"The work studies CBD interactions with polyvinylpyrrolidone (PVP), PVP/VA copolymer, hydroxypropyl methylcellulose phthalate (HPMCP), hydroxypropyl methylcellulose acetate succinate (HPMCAS), and poly(methyl methacrylate) (PMMA).\"},{\"question\":\"How do polymer–CBD hydrogen bonds and polymer–polymer interactions affect mixing behavior?\",\"answer\":\"Positive deviations from ideal mixing are linked to stable polymer–CBD hydrogen bonds, while negative deviations arise when polymer–polymer hydrogen-bond networks are disrupted. These effects influence dissolution trends through how water and CBD interact with each polymer.\"}]",1783378267,86,{"code":4,"msg":31,"data":32},"ok",{"site_id":25,"language":24,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"molecular-interactions-underlying-dissolution-trends-in-cannabidiol-polymer-amorphous-solid-dispersions","",{"@graph":36,"@context":85},[37,53,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,47,50],{"item":41,"name":42,"@type":43,"position":21},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":20},"https://docshare.wps.com/document/","Document",{"item":48,"name":12,"@type":43,"position":49},"https://docshare.wps.com/document/research-report/",3,{"item":51,"name":13,"@type":43,"position":52},"https://docshare.wps.com/document/molecular-interactions-underlying-dissolution-trends-in-cannabidiol-polymer-amorphous-solid-dispersions/43181/",4,{"url":51,"name":13,"@type":54,"author":55,"headline":13,"publisher":57,"fileFormat":60,"inLanguage":24,"description":14,"dateModified":61,"datePublished":62,"encodingFormat":60,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":56},"Person",{"url":41,"name":58,"@type":59},"DocShare","Organization","application/pdf","2026-07-18","2026-07-06",true,{"@type":65,"interactionType":66,"userInteractionCount":20},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"Why is CBD dissolution a limiting factor for its therapeutic effectiveness?","Question",{"text":75,"@type":76},"CBD has poor aqueous solubility and high lipophilicity, which reduce bioavailability and slow dissolution. The document frames solubility as a key barrier for oral effectiveness.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"Which polymers are investigated for CBD-containing ASD formulations?",{"text":80,"@type":76},"The work studies CBD interactions with polyvinylpyrrolidone (PVP), PVP/VA copolymer, hydroxypropyl methylcellulose phthalate (HPMCP), hydroxypropyl methylcellulose acetate succinate (HPMCAS), and poly(methyl methacrylate) (PMMA).",{"name":82,"@type":73,"acceptedAnswer":83},"How do polymer–CBD hydrogen bonds and polymer–polymer interactions affect mixing behavior?",{"text":84,"@type":76},"Positive deviations from ideal mixing are linked to stable polymer–CBD hydrogen bonds, while negative deviations arise when polymer–polymer hydrogen-bond networks are disrupted. These effects influence dissolution trends through how water and CBD interact with each polymer.","https://schema.org",{"og:url":51,"og:type":87,"og:title":13,"og:site_name":58,"og:description":14},"article",{"robots":89,"canonical":51},"index,follow",{"doc_id":7,"site_id":25},{"code":4,"msg":5,"data":92},[93,97,101,105,110,115,120,123,128,131,135],{"id":21,"doc_module":4,"doc_module_name":46,"category_name":94,"show_sort_weight":95,"slug":96},"Story & Novel",90,"story-novel",{"id":20,"doc_module":4,"doc_module_name":46,"category_name":98,"show_sort_weight":99,"slug":100},"Literature",80,"literature",{"id":52,"doc_module":4,"doc_module_name":46,"category_name":102,"show_sort_weight":103,"slug":104},"Exam",70,"exam",{"id":106,"doc_module":4,"doc_module_name":46,"category_name":107,"show_sort_weight":108,"slug":109},5,"Comic",60,"comic",{"id":111,"doc_module":4,"doc_module_name":46,"category_name":112,"show_sort_weight":113,"slug":114},6,"Technology",50,"technology",{"id":116,"doc_module":4,"doc_module_name":46,"category_name":117,"show_sort_weight":118,"slug":119},7,"Healthcare",40,"healthcare",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":121,"slug":122},30,"research-report",{"id":124,"doc_module":4,"doc_module_name":46,"category_name":125,"show_sort_weight":126,"slug":127},9,"Religion & Spirituality",20,"religion-spirituality",{"id":126,"doc_module":4,"doc_module_name":46,"category_name":129,"show_sort_weight":126,"slug":130},"World Cup","world-cup",{"id":132,"doc_module":4,"doc_module_name":46,"category_name":133,"show_sort_weight":132,"slug":134},10,"Lifestyle","lifestyle",{"id":136,"doc_module":4,"doc_module_name":46,"category_name":137,"show_sort_weight":106,"slug":138},19,"General","general"]