[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329586-105":59,"doc-detail-329586-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","molecular-biomarkers-in-cutaneous-photodynamic-therapy-a-comprehensive-review","Molecular Biomarkers in Cutaneous Photodynamic Therapy - A Comprehensive Review","","Photodynamic therapy (PDT) is widely used in dermatology, yet the precise biomolecular changes driving clinical outcomes remain only partly clarified. This narrative review synthesizes peer-reviewed studies and clinical trials to map molecular biomarkers and underlying mechanisms of PDT in cutaneous disorders. Findings highlight reduced expression of proliferation markers such as p53, Cyclin D1, and Ki-67, along with enhanced apoptosis, plus extracellular matrix remodeling and collagen stimulation relevant to skin rejuvenation and chronic wound management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/molecular-biomarkers-in-cutaneous-photodynamic-therapy-a-comprehensive-review/329586/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/molecular-biomarkers-in-cutaneous-photodynamic-therapy-a-comprehensive-review/329586.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main goal of this review on cutaneous photodynamic therapy?","Question",{"text":112,"@type":113},"To explore molecular biomarkers involved in PDT, evaluate its mechanisms, and explain how these insights may improve treatment protocols and personalization in dermatology.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which biomarker changes are reported after PDT in actinic keratosis and cancerous lesions?",{"text":117,"@type":113},"PDT reduces expression of key biomarkers including p53, Cyclin D1, and Ki-67, leading to decreased cell proliferation and increased apoptosis.",{"name":119,"@type":110,"acceptedAnswer":120},"How does PDT contribute to tissue remodeling and skin-related outcomes?",{"text":121,"@type":113},"Beyond cell death pathways, PDT promotes extracellular matrix remodeling and stimulates collagen production, supporting skin rejuvenation and a promising role in chronic wound treatment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329586,1790122416,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","Review  \nMolecular Biomarkers in Cutaneous Photodynamic Therapy: A Comprehensive Review  \nJorge Naharro-Rodriguez 1,2, *, Stefano Bacci 3 and Montserrat Fernandez-Guarino 2  \nCitation: Naharro-Rodriguez, J.; Bacci, S.; Fernandez-Guarino, M. Molecular Biomarkers in Cutaneous Photodynamic Therapy: A Comprehensive Review. Diagnostics 2024, 14, 2724. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/diagnostics14232724](10.3390/diagnostics14232724)  \nAcademic Editor: Giulia Ciccarese  \nReceived: 13 November 2024  \nAccepted: 2 December 2024  \nPublished: 3 December 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Programa de Doctorado en Ciencias de la Salud, Universidad de Alcalá de Henares, 28801 Madrid, Spain  \n2 Dermatology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain; [drafernandezguarino@gmail.com](drafernandezguarino@gmail.com)  \n3 Research Unit of Histology and Embriology, Department of Biology, University of Florence,  \n50139 Florence, Italy; [stefano.bacci@unifi.it](stefano.bacci@unifi.it)  \n* [Correspondence: jorgenrmed@gmail.com](Correspondence: jorgenrmed@gmail.com)  \nAbstract: Background/Objectives: Photodynamic therapy (PDT) is widely utilized in dermatology for the treatment of various skin conditions. Despite its effectiveness, the exact biomolecular changes underlying therapeutic outcomes remain only partially understood. This review, through a transversal approach, aims to provide an in-depth exploration of molecular biomarkers involved in PDT, evaluate its underlying mechanisms, and examine how these insights can contribute to enhanced treatment protocols and personalized therapy approaches. Methods: A narrative review of the literature was conducted, targeting peer-reviewed articles and clinical trials that focus on PDT and its molecular biomarker effects on dermatological conditions. The databases searched included PubMed, Scopus, and Web of Science, and the inclusion criteria encompassed original research articles, systematic reviews, and meta-analyses in English. Results: PDT effectively reduces the expression of critical biomarkers such as p53, Cyclin D1, and Ki-67 in AK and other cancerous lesions, leading to reduced cell proliferation and increased apoptosis. Additionally, PDT promotes extracellular matrix remodeling and stimulates collagen production, which has a rejuvenating effect on the skin and a promising role in the treatment of chronic wounds. Conclusions: PDT represents a powerful and versatile treatment option for various dermatological conditions due to its ability to target cellular pathways involved in proliferation and apoptosis. Further research into optimizing treatment parameters and combining PDT with other targeted therapies may enhance patient outcomes, reduce resistance, and pave the way for more individualized therapeutic approaches in dermatology.  \nKeywords: photodynamic therapy; dermatology; biomarkers; histology  \n1. Introduction  \nPhotodynamic therapy (PDT) is a well-known technique widely used by dermatologists for the treatment of non-melanoma skin cancer and precancerous conditions. The main advantage of PDT is the treatment of tumoral and precancerous skin lesions while avoiding surgical excision. This approach is indicated for non-high-risk tumoral lesions with an excellent cosmetic result [1,2] . Regarding precancerous skin lesions, such as actinic keratosis (AK), PDT allows the treatment of extended field cancerization areas with approximate cure rates of 80%, making it one of the most effective treatments for this condition [3] . There is some evidence of PDT’s capacity to prevent non-melanoma skin cancer, but AK progres","cbCaihgfWadIKiOy","https://ap.wps.com/l/cbCaihgfWadIKiOy","pdf",306779,18,"English","# Abstract\n# Introduction\n## Photodynamic therapy in dermatology\n## Mechanisms and histological effects\n# Review aim","[{\"question\":\"What is the main goal of this review on cutaneous photodynamic therapy?\",\"answer\":\"To explore molecular biomarkers involved in PDT, evaluate its mechanisms, and explain how these insights may improve treatment protocols and personalization in dermatology.\"},{\"question\":\"Which biomarker changes are reported after PDT in actinic keratosis and cancerous lesions?\",\"answer\":\"PDT reduces expression of key biomarkers including p53, Cyclin D1, and Ki-67, leading to decreased cell proliferation and increased apoptosis.\"},{\"question\":\"How does PDT contribute to tissue remodeling and skin-related outcomes?\",\"answer\":\"Beyond cell death pathways, PDT promotes extracellular matrix remodeling and stimulates collagen production, supporting skin rejuvenation and a promising role in chronic wound treatment.\"}]","Molecular Biomarkers in Cutaneous Photodynamic Therapy - A Comprehensive Review | PDF",1789984647,45]