[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31832":3,"doc-seo-31832":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31832,5909877438554,"Maeve","https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272",7,"Healthcare","Molecular basis of β-thalassemia in Indonesia: Application to prenatal","This document delves into the molecular underpinnings of β-thalassemia, a genetic blood disorder, specifically within the Indonesian population, and explores its application in prenatal diagnosis. The research likely involves detailed genetic analysis of the β-globin gene, identifying specific mutations prevalent in Indonesia that lead to the disease. It would also discuss methodologies for detecting these mutations during pregnancy to facilitate informed reproductive decisions. The document's focus on prenatal application suggests an emphasis on genetic counseling, diagnostic techniques, and potential therapeutic considerations for affected families. Given the nature of the topic, it's expected to involve scientific literature, case studies, and perhaps epidemiological data concerning β-thalassemia in Indonesia, aiming to provide a comprehensive understanding of the disease's genetic landscape and its implications for public health and reproductive medicine. The figure displays a schematic of a gene with three exons and primers labeled a-h. Subsequent figures show DNA sequences and a normal allele subjected to specific chemical reactions, likely related to DNA sequencing or mutation detection techniques.","cbCais4FhFRjHZqn","https://ap.wps.com/l/cbCais4FhFRjHZqn","pdf",2246895,1,10,"English","en","# Molecular Basis of β-thalassemia in Indonesia: Application to Prenatal","[{\"question\":\"What is the primary focus of this document?\",\"answer\":\"The document focuses on the molecular basis of β-thalassemia in Indonesia and its application in prenatal diagnosis.\"},{\"question\":\"What is depicted in the first image?\",\"answer\":\"The first image shows a schematic of a gene with three exons (exon-1, exon-2, exon-3) and an indication of the 5' to 3' direction, along with primer locations labeled a through h.\"},{\"question\":\"What do the subsequent images illustrate?\",\"answer\":\"The subsequent images show DNA sequences under labels a, b, and d, and a normal allele with a specific sequence under labels a, c, and d, followed by a biochemical reaction process involving mixing, boiling, hybridization, and hydroxylamine and piperidine reactions, likely for mutation analysis or sequencing.\"}]",1780261313,25,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"molecular-basis-of-thalassemia-in-indonesia-application-to-prenatal","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/healthcare/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/molecular-basis-of-thalassemia-in-indonesia-application-to-prenatal/31832/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-31",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What is the primary focus of this document?","Question",{"text":73,"@type":74},"The document focuses on the molecular basis of β-thalassemia in Indonesia and its application in prenatal diagnosis.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"What is depicted in the first image?",{"text":78,"@type":74},"The first image shows a schematic of a gene with three exons (exon-1, exon-2, exon-3) and an indication of the 5' to 3' direction, along with primer locations labeled a through h.",{"name":80,"@type":71,"acceptedAnswer":81},"What do the subsequent images illustrate?",{"text":82,"@type":74},"The subsequent images show DNA sequences under labels a, b, and d, and a normal allele with a specific sequence under labels a, c, and d, followed by a biochemical reaction process involving mixing, boiling, hybridization, and hydroxylamine and piperidine reactions, likely for mutation analysis or sequencing.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]