[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-151753-en":3,"doc-seo-151753-105":30,"detail-sidebar-cat-0-en-105":92},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},151753,2336475104042,"Tawan","https://ap-avatar.wpscdn.com/avatar/22000c4c32af1715be0?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786537525561427321",7,"Healthcare","Modulation of memory and conditioning by pain during sedation with anesthetics - Study consent form","This consent form explains a research study aimed at understanding factors that allow or prevent memory formation in people receiving intravenous anesthesia while experiencing pain. Participants complete four study visits involving screening (urine pregnancy and drug screen), questionnaires on sleep, stress, anxiety, depression, and pain, pain calibration via nerve stimulation, physical assessment, IV catheter placement, monitoring of heart rate, blood pressure, and breathing, and potential MRI scanning with memory testing.","2IILFLDO 7LWOH 􀀝 0RGXODWLRQ RI 0HPRU\\ DQG &RQGLWLRQLQJ E\\ 3DLQ 'XULQJ 6HGDWLRQ :LWK $QHVWKHWLFV &OLQLFDO7ULDOV􀀑JRY ,' 􀀝 1&7􀀓􀀗􀀓􀀙􀀕􀀔􀀕􀀖  \n'RFXPHQW 'DWH 􀀝 􀀗􀀒􀀕􀀒􀀕􀀓􀀕􀀗  \nUPMC |  \nUniversity of Pittsburgh Medical Center  \nDepartment of Anesthesiology & Perioperative Medicine  \nSTUDY consent form  \nKEY INFORMATION  \nStudy Title: Modulation of memory and conditioning by pain during sedation with anesthetics  \n1. You are being offered the opportunity to participate in a research study. One of the investigators will explain the study to you and will answer any questions you might have. You should take your time to make your decision, which is completely voluntary.  \n2A. Summary of the research  \nPurpose of the research: The purpose of this study is to better understand what factors allow or prevent memories to be formed in people receiving IV anesthesia and experiencing pain.  \nDuration, number of study visits: There are four visits associated with participation in this study. The first visit will last approximately 3-4 hours. The second visit must occur the next day and will last approximately 1 hour. At least 5 days later, the third visit will occur, lasting 3-4 hours. The fourth visit, which will occur the day after visit 3, will last approximately 1 hour.  \nOverview of study procedures:  \n• urine pregnancy & drug screen  \n• questionnaires about your sleep, stress, anxiety, depression, and pain  \n• nerve stimulator calibration to a pain intensity of 5-7/10  \n• brief physical exam including evaluation of the health of your lungs, heart, neck and mouth  \n• questions about medical conditions, past surgeries, medications, allergies, substance (drug) use, and any symptoms that you have during physical activity  \n• intravenous (IV) catheter placement (using a needle)  \n• connection to monitor that measures your heart rate, blood pressure, and breathing  \n• potential MRI scanning and MRI safety screening questions  \n• enter the high magnetic field environment of the MRI scanner  \n• connection to monitor that measures your heart rate, blood pressure, and breathing  \n• placement inside the MRI scanner  \n• listen to recordings, look at images while experiencing painful stimulation and being scanned by the MRI  \n• next-day memory testing using a computer  \n• additional questionnaires about sleep, stress, anxiety, depression, and pain  \n3. Reasonable, foreseeable risks or discomforts  \nRisks and side effects related to the MRI scanning include those which are: Likely: Discomfort from loud noise, positional discomfort  \nRare but serious: claustrophobia, risk of interaction with undetected/undisclosed metal in/on subject's body that could cause physical injury; hearing damage/loss  \nPage 1 of 11  \nUniversity of Pittsburgh STUDY19030183 Effective: 4/2/2024 Expires: 4/ 1/2025  \nRisks and side effects related to the collection & storage of personal health information include those which are:  \nRare but serious: Breach of confidentiality  \nRisks and side effects related to the electric nerve stimulation include those which are: Likely: Pain due to electric shock  \nRare but serious: Theoretical risk of burns due to an interaction with MRI scanner  \nRisks and side effects related to the deep anesthesia include those which are: Likely: Residual sedation that will resolve over time  \nRare but serious: Corneal abrasion, need for airway intervention leading to nasal, pharyngeal, or laryngeal soft tissue injury, need for resuscitative medication administration  \nRisks and side effects related to the fentanyl administration include those which are: Likely: Itching, nausea, sedation  \nLess Likely: constipation  \nRare but serious: Allergic reaction (rash, itching), low blood pressure, slow heart rate, shallow or absent breathing, addiction/dependence, abdominal pain,  \nRisks and side effects related to the dexmedetomidine administration include those which are: Likely: Sedation, low or high blood pressure, slow or fast heart rate, dry mouth  \nRare but serious: Naus","cbCairOoSk5he3BR","https://ap.wps.com/l/cbCairOoSk5he3BR","pdf",619677,1,12,"English","en",105,"# Study overview\n## Purpose\n## Study duration and visits\n## Study procedures\n# Risks and discomforts\n## MRI-related risks\n## Personal health information risks\n## Electric nerve stimulation risks\n## Anesthesia and medication risks\n# Expected benefits\n# Consent information","[{\"question\":\"What is the purpose of this study?\",\"answer\":\"To better understand what factors allow or prevent memories from being formed in people receiving IV anesthesia while experiencing pain.\"},{\"question\":\"How many study visits are involved, and how long are they?\",\"answer\":\"Four visits: visit 1 lasts about 3–4 hours; visit 2 occurs the next day for about 1 hour; visit 3 occurs at least 5 days later for about 3–4 hours; visit 4 occurs the day after visit 3 for about 1 hour.\"},{\"question\":\"What are the main foreseeable risks during the study?\",\"answer\":\"Risks include discomfort from loud MRI noise and positioning, claustrophobia, possible confidentiality breaches, pain from electric nerve stimulation, potential MRI-related injury from undetected metal, and side effects from deep anesthesia and study medications such as itching, nausea, sedation, and blood pressure or breathing changes.\"}]","Modulation of memory and conditioning by pain during sedation with anesthetics - Study consent form | PDF",1787848392,30,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":87,"head_meta":89,"extra_data":91,"updated_unix":28},"modulation-of-memory-and-conditioning-by-pain-during-sedation-with-anesthetics-study-consent-form","",{"@graph":36,"@context":86},[37,54,69],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/modulation-of-memory-and-conditioning-by-pain-during-sedation-with-anesthetics-study-consent-form/151753/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":63,"encodingFormat":61,"isAccessibleForFree":64,"interactionStatistic":65},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-09-04","2026-08-27",true,{"@type":66,"interactionType":67,"userInteractionCount":20},"InteractionCounter",{"@type":68},"ViewAction",{"@type":70,"mainEntity":71},"FAQPage",[72,78,82],{"name":73,"@type":74,"acceptedAnswer":75},"What is the purpose of this study?","Question",{"text":76,"@type":77},"To better understand what factors allow or prevent memories from being formed in people receiving IV anesthesia while experiencing pain.","Answer",{"name":79,"@type":74,"acceptedAnswer":80},"How many study visits are involved, and how long are they?",{"text":81,"@type":77},"Four visits: visit 1 lasts about 3–4 hours; 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