[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-372113-105":59,"doc-detail-372113-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","modulating-lipid-metabolism-improves-tumor-immunotherapy","Modulating lipid metabolism improves tumor immunotherapy","","Immunotherapy has advanced cancer care, yet treatment outcomes vary due to multiple determinants. Abnormal lipid metabolism, commonly seen in tumors, can drive proliferation, invasion, and metastasis by reshaping the tumor microenvironment. Reported work links lipid metabolic scoring with altered fatty acid oxidation in tumor-associated macrophages and improved T-cell infiltration, supporting better anti–PD-1 responses. Overall, lipid metabolism functions as an immune regulator, and targeting its reprogramming offers a new strategy for combination tumor therapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/modulating-lipid-metabolism-improves-tumor-immunotherapy/372113/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/modulating-lipid-metabolism-improves-tumor-immunotherapy/372113.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does abnormal lipid metabolism affect immunotherapy outcomes?","Question",{"text":112,"@type":113},"Abnormal lipid metabolism promotes tumor progression and alters the tumor microenvironment, which can impair immune cell function and reduce immunotherapy efficacy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does lipid metabolism scoring play in predicting immunotherapy efficiency?",{"text":117,"@type":113},"A lipid metabolism-related scoring model can be constructed to reflect metabolic status in patients with cancer and help predict immunotherapy response.",{"name":119,"@type":110,"acceptedAnswer":120},"What mechanisms are described for fatty acids influencing T-cell antitumor activity?",{"text":121,"@type":113},"Fatty acids can affect T-cell function through changes in mitochondrial metabolism and signaling pathways, and by modifying the availability and composition of lipids within the tumor microenvironment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},372113,1791098741,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Open access Commentary  \n Modulating lipid metabolism improves tumor immunotherapy  \nYu Ping,1 Qiuqing Fan,1 Yi Zhang  1,2,3,4,5  \nTo cite: Ping Y, Fan Q, Zhang Y. Modulating lipid metabolism improves tumor immunotherapy. Journal for ImmunoTherapy of Cancer 2025;13:e010824 . doi:10.1136/jitc-2024-010824  \nAccepted 21 January 2025  \n© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.  \n1Biotherapy Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China  \n2State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou, Henan, China  \n3School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China 4Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China 5School of Public Health, Zhengzhou University, Zhengzhou, Henan, China  \nCorrespondence to  \nYi Zhang; [yizhang@zzu.edu.cn](yizhang@zzu.edu.cn)  \nABSTRACT  \nImmunotherapy has progressed significantly in cancer treatment; however, several factors influence its outcomes. Abnormal lipid metabolism, which is frequently observed in cancers, promotes tumor proliferation, invasion, and metastasis. Li etal from the Medical Oncology Department of Chongqing University Cancer Hospital constructed a lipid metabolism scoring system and reported that MK1775 inhibited fatty acid oxidation in tumor-associated macrophages and enhanced T-cell infiltration, further enhancing the efficacy of immunotherapy. This study demonstrated the critical role of lipid metabolism scoring system and lipid metabolism in immunotherapy. Currently, the metabolism of lipids, such as fatty acids, phospholipids, and cholesterol, has been reported to affect the tumor microenvironment by regulating immune cells, including T cells, natural killer cells, and macrophages. These metabolic changes can impair the efficacy of immunotherapy, resulting in tumor progression. Consequently, lipid metabolism emerges as an important immune regulator for improving immunotherapeutic outcomes and provides a novel and powerful strategy for tumor combination therapy.  \nImmunotherapies, such as immune checkpoint blockade, have demonstrated breakthrough success in cancer treatment. Anti-programmed cell death protein-1 (PD-1) therapy, approved for clinical applications, is a type of immune checkpoint blockade that specifically binds to PD-1 in T cells to prevent its interaction with programmed death-ligand 1, thereby enhancing T-cell anti-tumor function and eliminating tumor cells. However, many patients do not achieve optimal clinical responses. Decreased antitumor function of T cells, primarily influenced by the tumor microenvironment (TME), is critical. Many factors within the TME, including immunosuppressive elements and abnormal metabolism, restrict the antitumor function of T cells. Li et al developed a lipid metabolism scoring system using the data from The Cancer Genome Atlas, identifying that abnormal lipid metabolism in the TME affects tumor progression. They screened drugs that modulated lipid metabolism in the TME to enhance anti-PD-1 treatment.1 The construction of a lipid metabolism-related  \nmodel is beneficial for predicting immunotherapy efficiency.2 These demonstrate that establishing a unique lipid metabolic scoring system facilitates a better understanding of the metabolic status of patients with cancer, enabling targeted and precise treatment.  \nLipid metabolism is an important process by which cells acquire energy, maintain cellular membranes, and perform normal signal transduction. Cellular lipids mainly comprise fatty acids, phospholipids, and cholesterol. In cancer, lipid metabolism is associated with tumor progression and immunosuppression.3 Li et al reported that DKK1, ANLN, and CCNA2 are highly expressed atthe tumor site and are associated with poor prognosis. MK1775 modulates lipid metabolism, revea","cbCaic5BEUOB1JZc","https://ap.wps.com/l/cbCaic5BEUOB1JZc","pdf",666347,"English","# Abstract\n## Lipid metabolism and immunotherapy outcomes\n## Immune checkpoint blockade and T-cell dysfunction in TME\n## Fatty acid metabolism and T-cell regulation\n## Figure 1: Intervention of lipid metabolism to improve immunotherapy","[{\"question\":\"How does abnormal lipid metabolism affect immunotherapy outcomes?\",\"answer\":\"Abnormal lipid metabolism promotes tumor progression and alters the tumor microenvironment, which can impair immune cell function and reduce immunotherapy efficacy.\"},{\"question\":\"What role does lipid metabolism scoring play in predicting immunotherapy efficiency?\",\"answer\":\"A lipid metabolism-related scoring model can be constructed to reflect metabolic status in patients with cancer and help predict immunotherapy response.\"},{\"question\":\"What mechanisms are described for fatty acids influencing T-cell antitumor activity?\",\"answer\":\"Fatty acids can affect T-cell function through changes in mitochondrial metabolism and signaling pathways, and by modifying the availability and composition of lipids within the tumor microenvironment.\"}]","Modulating lipid metabolism improves tumor immunotherapy | PDF",1790193733]